1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB 243213 hydrochloride

SB 243213 hydrochloride 

Cat. No.: HY-103112
Handling Instructions

SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile.

For research use only. We do not sell to patients.

SB 243213 hydrochloride Chemical Structure

SB 243213 hydrochloride Chemical Structure

CAS No. : 200940-23-4

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Description

SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1].

IC50 & Target[1]

5-HT2C Receptor

9.37 (pKi)

In Vivo

SB-243213 hydrochloride is a potent inhibitor of central 5-HT2C receptor-mediated function in rats. SB-243213 hydrochloride exhibits anxiolytic-like activity in both the social interaction and Geller-Seifter conflict tests[1].

Molecular Weight

464.87

Formula

C₂₂H₂₀ClF₃N₄O₂

CAS No.

200940-23-4

SMILES

O=C(N1CCC2=C1C=C(C(F)(F)F)C(C)=C2)NC3=CC=C(OC4=CC=CN=C4C)N=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SB 243213SB243213SB-2432135-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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SB 243213 hydrochloride
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HY-103112
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