1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB 243213 hydrochloride

SB 243213 hydrochloride 

Cat. No.: HY-103112
Handling Instructions

SB 243213 hydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.

For research use only. We do not sell to patients.

SB 243213 hydrochloride Chemical Structure

SB 243213 hydrochloride Chemical Structure

CAS No. : 200940-23-4

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Description

SB 243213 hydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1].

IC50 & Target[1]

5-HT2C Receptor

9.37 (pKi)

In Vitro

SB 243213 hydrochloride showed little affinity (pKi<6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It showed weak affinity (pKi<6.5) for the cloned human 5-HT1D and D3 receptors and moderate affinity (pKi=6.7) for the cloned human D2 receptor[1].

In Vivo

SB 243213 hydrochloride (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box[1].
SB 243213 hydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction[1].

Animal Model: Male Sprague-Dawley experimentally naive rats (220-300 g)[1]
Dosage: 0.1, 0.3, 1, 3, 10 mg/kg
Administration: p.o.; 1 hour pre-test
Result: Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.
Molecular Weight

464.87

Formula

C₂₂H₂₀ClF₃N₄O₂

CAS No.

200940-23-4

SMILES

O=C(N1CCC2=C1C=C(C(F)(F)F)C(C)=C2)NC3=CC=C(OC4=CC=CN=C4C)N=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SB 243213SB243213SB-2432135-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorOrally5-hydroxytryptamineanxiolyticprofileschizophreniamotordisordersInhibitorinhibitorinhibit

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SB 243213 hydrochloride
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HY-103112
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