1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. CX516

CX516 (Synonyms: BDP 12)

Cat. No.: HY-10933 Purity: 99.50%
Handling Instructions

CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).

For research use only. We do not sell to patients.

CX516 Chemical Structure

CX516 Chemical Structure

CAS No. : 154235-83-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 132 In-stock
Estimated Time of Arrival: December 31
100 mg USD 158 In-stock
Estimated Time of Arrival: December 31
200 mg USD 277 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CX516

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI)[1].

IC50 & Target

AMPA receptor[1]

In Vivo

The specific extradimensional deficits produced by sub-chronic or early postnatal postnatal phencyclidine treatment were significantly attenuated by CX516 (10, and 20 mg/kg, s.c.)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Lister Hooded rats (56-63 postnatal day)[1]
Dosage: 5, 10, 20, and 40 mg/kg
Administration: Subcutaneously
Result: Two doses (10 and 20 mg/kg) were highly significant in improving the extradimensional shift deficit induced by either treatment regimes.
Two doses (5 and 40 mg/kg) was ineffective at reversing the extradimensional impairment induced by the sub-chronic postnatal phencyclidine treatment regime.
Clinical Trial
Molecular Weight

241.29

Formula

C14H15N3O

CAS No.
SMILES

O=C(N1CCCCC1)C2=CC3=NC=CN=C3C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (414.44 mM; Need ultrasonic)

DMSO : ≥ 41 mg/mL (169.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1444 mL 20.7220 mL 41.4439 mL
5 mM 0.8289 mL 4.1444 mL 8.2888 mL
10 mM 0.4144 mL 2.0722 mL 4.1444 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (11.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (11.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (11.40 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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  • Molarity Calculator

  • Dilution Calculator

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
CX516
Cat. No.:
HY-10933
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