1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. CX516

CX516 (Synonyms: BDP 12)

Cat. No.: HY-10933 Purity: 99.95%
Handling Instructions

CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).

For research use only. We do not sell to patients.

CX516 Chemical Structure

CX516 Chemical Structure

CAS No. : 154235-83-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
Estimated Time of Arrival: December 31
100 mg USD 144 In-stock
Estimated Time of Arrival: December 31
200 mg USD 252 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI)[1].

IC50 & Target

AMPA receptor[1]

In Vivo

The specific extradimensional deficits produced by sub-chronic or early postnatal postnatal phencyclidine treatment were significantly attenuated by CX516 (10, and 20 mg/kg, s.c.)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Lister Hooded rats (56-63 postnatal day)[1]
Dosage: 5, 10, 20, and 40 mg/kg
Administration: Subcutaneously
Result: Two doses (10 and 20 mg/kg) were highly significant in improving the extradimensional shift deficit induced by either treatment regimes.
Two doses (5 and 40 mg/kg) was ineffective at reversing the extradimensional impairment induced by the sub-chronic postnatal phencyclidine treatment regime.
Clinical Trial
Molecular Weight

241.29

Formula

C₁₄H₁₅N₃O

CAS No.

154235-83-3

SMILES

O=C(N1CCCCC1)C2=CC3=NC=CN=C3C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 41 mg/mL (169.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1444 mL 20.7220 mL 41.4439 mL
5 mM 0.8289 mL 4.1444 mL 8.2888 mL
10 mM 0.4144 mL 2.0722 mL 4.1444 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (11.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (11.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (11.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CX516BDP 12CX 516CX-516BDP12BDP-12iGluRIonotropic glutamate receptorsampakineAMPAreceptorpositiveallostericmodulatorAlzheimerschizophreniaInhibitorinhibitorinhibit

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CX516
Cat. No.:
HY-10933
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