2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. SKF 83822

SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia.

For research use only. We do not sell to patients.

SKF 83822 Chemical Structure

SKF 83822 Chemical Structure

CAS No. : 74115-08-5

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Based on 1 publication(s) in Google Scholar

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Description

SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia[1][2].

IC50 & Target[1]

Rat D1 Receptor

 

In Vivo

SKF 83822 (25-100 μg/kg; s.c.; single dose after antagonist) produces a strong rotational response in rat in a dose-dependent manner. And it also stimulates strong expression of the IEG products c-Fos, Fra2, Zif/268 and Arc in the deinnervated striatum[1].
SKF 83822 shows significant effects in a moderate and high dose with 0.25 mg/kg and 0.35 mg/kg, respectively, in monkeys. And it (0.15-0.35 mg/kg; s.c.; single dose) induces locomotion but nor inducing dyskinesia. SKF 83822 results in a state of extreme arousal and locomotor activation without stereotypy[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult, male Sprague-Dawley derived rats[1]
Dosage: 6.25 μg/kg, 25 μg/kg, 50 μg/kg, and 100 μg/kg; with or without 0.5 mg/kg antagonist SCH 23390.
Administration: SC; single dose, 30 min after antagonist treatment.
Result: Produced a strong rotational response at 50 μg/kg which was approximately midway between that produced by the 25 and 100 μg/kg doses in the first experiment.
Could be inhibited by antagonist of dopamine D1 receptor, SCH 23390.
Molecular Weight

343.85

Formula

C20H22ClNO2
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

OC1=C(C=C2C(CN(CCC2=C1Cl)CC=C)C3=CC=CC(C)=C3)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (290.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9082 mL 14.5412 mL 29.0824 mL
5 mM 0.5816 mL 2.9082 mL 5.8165 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9082 mL 14.5412 mL 29.0824 mL 72.7061 mL
5 mM 0.5816 mL 2.9082 mL 5.8165 mL 14.5412 mL
10 mM 0.2908 mL 1.4541 mL 2.9082 mL 7.2706 mL
15 mM 0.1939 mL 0.9694 mL 1.9388 mL 4.8471 mL
20 mM 0.1454 mL 0.7271 mL 1.4541 mL 3.6353 mL
25 mM 0.1163 mL 0.5816 mL 1.1633 mL 2.9082 mL
30 mM 0.0969 mL 0.4847 mL 0.9694 mL 2.4235 mL
40 mM 0.0727 mL 0.3635 mL 0.7271 mL 1.8177 mL
50 mM 0.0582 mL 0.2908 mL 0.5816 mL 1.4541 mL
60 mM 0.0485 mL 0.2424 mL 0.4847 mL 1.2118 mL
80 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.9088 mL
100 mM 0.0291 mL 0.1454 mL 0.2908 mL 0.7271 mL
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SKF 83822 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF 8382274115-08-5SKF83822SKF-83822Dopamine ReceptorInhibitorinhibitorinhibit

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