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Aripiprazole Lauroxil 

Cat. No.: HY-108751
Handling Instructions

Aripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.

For research use only. We do not sell to patients.

Aripiprazole Lauroxil Chemical Structure

Aripiprazole Lauroxil Chemical Structure

CAS No. : 1259305-29-7

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Description

Aripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity[1].

In Vivo

Aripiprazole lauroxil (intravenous administration; 1.87 mg/ml) bioconversion in vivo involves the formation of an intermediate, N-hydroxymethyl aripiprazole, the in vitro data indicates a high bioconversion of aripiprazole lauroxil, thus, the concentration of N-hydroxymethyl aripiprazole observed in the animals dosed with aripiprazole lauroxil is surprisingly high[1].

Animal Model: Female Sprague Dawley rats[1]
Dosage: 1.87 mg/ml 
Administration: Blood samples is taken at 5, 15, 30 min and 1, 2, 4, 6, 8 and 24 h after administration
Result: Exhibits an clearance: 0.32 ± 0.11 L/h/kg. 
Molecular Weight

660.71

Formula

C₃₆H₅₁Cl₂N₃O₄

CAS No.

1259305-29-7

SMILES

CCCCCCCCCCCC(OCN1C(CCC2=C1C=C(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)C=C2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Aripiprazole LauroxilOthersAristada schizophreniaInhibitorinhibitorinhibit

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