Search Result
Results for "
sodium
" in MedChemExpress (MCE) Product Catalog:
26
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-148800
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VX-548
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Sodium Channel
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Neurological Disease
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Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy .
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- HY-108505
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- HY-132609
-
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Small Interfering RNA (siRNA)
Transthyretin (TTR)
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Neurological Disease
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Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis .
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- HY-108764
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ISIS 301012
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Apolipoprotein
HCV
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Metabolic Disease
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Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .
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- HY-147080
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ARC1905
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Complement System
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Others
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Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .
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- HY-B1610N
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Biochemical Assay Reagents
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Others
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Sodium Citrate Buffer, 0.1M, pH 4.0 is an acidic, aqueous buffer solution. Sodium Citrate Buffer, 0.1M, pH 4.0 resists pH fluctuations, chelates metal ions, and regulates the redox potential of the system. Sodium Citrate Buffer, 0.1M, pH 4.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .
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- HY-132608
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ISIS-420915 sodium
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Transthyretin (TTR)
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Neurological Disease
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Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy .
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- HY-101350
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- HY-Y1325H
-
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Environmental Pollutants
Fungal
Endogenous Metabolite
Caspase
PPAR
AMPK
Reactive Oxygen Species (ROS)
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
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Sodium acetate trihydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Sodium acetate trihydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Sodium acetate trihydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Sodium acetate trihydrate regulates energy metabolism. Sodium acetate trihydrate has anticancer activity against gastric cancer. Sodium acetate trihydrate induces writhing reaction and ulcerative colitis. Sodium acetate trihydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .
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- HY-B2243B
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sodium phosphate monobasic for molecular biology; Monosodium dihydrogen orthophosphate for molecular biology; Monosodium phosphate for molecular biology
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Environmental Pollutants
Biochemical Assay Reagents
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Others
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Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
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- HY-132613
-
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Small Interfering RNA (siRNA)
Glycolate Oxidase
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Metabolic Disease
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Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .
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- HY-B1610J
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Biochemical Assay Reagents
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Cancer
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Sodium Citrate Buffer, 0.5M, pH 5.0 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 5.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .
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- HY-Y0308H
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Disodium hydrogen phosphate, for molecular biology
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Biochemical Assay Reagents
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Others
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Sodium phosphate dibasic (Disodium hydrogen phosphate), for molecular biology, is a type of phosphate salt that can be used in molecular biology research to prepare stable buffers free of RNase/DNase/protease .
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- HY-B1610M
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Biochemical Assay Reagents
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Others
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Sodium Citrate Buffer, 0.5M, pH 6.5 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 6.5 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .
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- HY-160113
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Biochemical Assay Reagents
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Others
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Sodium phosphate buffer 0.02 M, pH 6.9 is a commonly used aqueous biological buffer that maintains a stable pH value. Sodium phosphate buffer 0.02 M, pH 6.9 is often used in enzyme activity assays, such as α-amylase assays. Sodium phosphate buffer 0.02 M, pH 6.9 is prepared by mixing disodium hydrogen phosphate (Na2HPO4) (HY-B2243) and sodium dihydrogen phosphate (NaH2PO4) (HY-Y0308) to a total concentration of 0.02 M .
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- HY-B2243D
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sodium phosphate monobasic, for cell culture; Monosodium dihydrogen orthophosphate, for cell culture; Monosodium phosphate, for cell culture
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Environmental Pollutants
Biochemical Assay Reagents
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Others
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Anhydrous sodium dihydrogen phosphate, for cell culture is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for cell culture can be used in cell culture .
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- HY-B1610L
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .
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- HY-B0834
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(RS)-Indoxacarb; DPX-JW062
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Environmental Pollutants
Sodium Channel
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Neurological Disease
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Indoxacarb ((±)-Indoxacarb; DPX-JW062) is a broad-spectrum oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. Indoxacarb blocks insect sodium channels in nerve preparations and isolated neurons .
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- HY-W020249
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Biochemical Assay Reagents
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Others
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Sodium ionophore X is a neutral ionophore that binds highly selectively to sodium ions (Na +) to form stable complexes. Sodium ionophore X can be used to construct ion-selective chemical sensors (including optical sensors and electrochemical sensors) .
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- HY-W019885A
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sodium triphosphate pentabasic, 98%
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Environmental Pollutants
Biochemical Assay Reagents
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Others
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Sodium tripolyphosphate (STPP), 98% is an inorganic, non-toxic polyphosphate crosslinker, inducer and enhancer. Sodium tripolyphosphate (STPP), 98% induces the formation of unique needle-like microcrystals in sodium alginate-chitosan composite films. Sodium tripolyphosphate (STPP), 98% enhances the DPPH free radical scavenging activity of sodium alginate-chitosan composite films .
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- HY-W034344
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Biochemical Assay Reagents
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Others
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Sodium methanesulfonate is a hygroscopic atmospheric aerosol, which typically forms from the reaction of methanesulfonic acid with sodium chloride or sea salt particles. Sodium methanesulfonate can serve as a substrate for oxidation reactions, undergoing heterogeneous oxidation by hydroxyl radicals at the air-aerosol interface, thereby initiating subsequent aerosol-phase chain reactions. Sodium methanesulfonate exhibits significant temperature-dependent deliquescence and efflorescence properties; particularly at lower temperatures relevant to the troposphere, its deliquescence and efflorescence relative humidity increase accordingly .
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- HY-109561
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EYE001; NX1838
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VEGFR
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Metabolic Disease
Inflammation/Immunology
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Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, which is directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .
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- HY-B1402B
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Hydrocortisone 21-hemisuccinate sodium
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Glucocorticoid Receptor
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Cardiovascular Disease
Metabolic Disease
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Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC) .
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- HY-159819
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Sodium Channel
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Neurological Disease
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Vormatrigine is an orally active sodium channel inhibitor with anti-epileptic activity. Vormatrigine can be used to study human focal and generalized epilepsy .
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- HY-B1243
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Sodium Channel
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Neurological Disease
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Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation.
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- HY-156596
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- HY-145558
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- HY-132607A
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CEBPA-51 sodium
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MicroRNA
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Inflammation/Immunology
Cancer
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MTL-CEBPA (sodium) is the sodium form of MTL-CEBPA (HY-132607). MTL-CEBPA (sodium) is a small activating RNA targeting for upregulation of C/EBPα. MTL-CEBPA (sodium) has anti-inflammatory and anti-cancer activity .
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- HY-W014841
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- HY-132818
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P-1037
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Sodium Channel
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Others
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Idrevloride, an epithelial sodium channel (ENaC) inhibitor (WO2016133967), can be used for the research of skin disorders .
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- HY-W133954
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Biochemical Assay Reagents
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Others
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Sodium metaborate tetrahydrate, 99% is a derivative of the borax compound. Sodium metaborate tetrahydrate, 99% can be used as a source of boron in the production of sodium borohydride (NaBH4) .
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- HY-Y0344H
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Halite (Pharmaceutical primary standard, USP)
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Biochemical Assay Reagents
Na+/K+ ATPase
Interleukin Related
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Inflammation/Immunology
Cancer
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Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells .
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- HY-B1610K
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. .
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- HY-117714
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Sodium Channel
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Neurological Disease
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AZD-3161 is a potent and selective blocker of NaV1.7 channel, with a pIC50 of 7.1. AZD-3161 can be used for the research of neuropathic and inflammatory pain .
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- HY-164068
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Biochemical Assay Reagents
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Others
Inflammation/Immunology
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Cross-linked sodium hyaluronate gel is a biomaterial formed by cross-linking sodium hyaluronate. Cross-linked sodium hyaluronate gel has good moisturizing properties, viscoelasticity and biocompatibility. Cross-linked sodium hyaluronate gel can be used for the treatment of arthritis and the development of auxiliary materials in ophthalmic surgery .
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- HY-Y0332H
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sodium phosphate monobasic dihydrate, for molecular biology
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Biochemical Assay Reagents
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Others
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Sodium dihydrogen phosphate dihydrate (Sodium phosphate monobasic dihydrate), for molecular biology is a phosphate compound and nucleating agent. At a content of 1.2%, Sodium dihydrogen phosphate dihydrate, for molecular biology eliminates the supercooling degree of sodium acetate trihydrate to 0°C while maintaining or slightly enhancing its latent heat storage capacity. Sodium dihydrogen phosphate dihydrate, for molecular biology can serve as a starting material for the synthesis of degradable sodium phosphate glasses, which are applied in craniomaxillofacial bone repair. Sodium dihydrogen phosphate dihydrate, for molecular biology is widely used in research on craniomaxillofacial bone repair and related fields .
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- HY-W008585
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- HY-121188
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Dibromo-dodecenyl-methylsulfimide
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Cytochrome P450
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Cardiovascular Disease
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DDMS (Dibromo-dodecenyl-methylsulfimide) is a selective 20-HETE production inhibitor. DDMS attenuates the vasodilatory response to sodium nitroprusside (SNP) .
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- HY-D1442
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Fluorescent Dye
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Others
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SBFI (tetraammonium), the tetraammonium salt of SBFI, is a cell-impermeant sodium fluorescence indicator. SBFI (tetraammonium) is sodium-sensitive dye. The excitation wavelength is set 333 nm, and the emission wavelength is 539 nm for SBFI .
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- HY-132606C
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Small Interfering RNA (siRNA)
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Metabolic Disease
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Scrambled Nedosiran sodium is a scrambled sequence of Nedosiran sodium (HY-132606A). Scrambled Nedosiran sodium has a random sequence of the amino acids that are the same as the active fragment Nedosiran sodium. Scrambled Nedosiran sodium is usually used as a negative control .
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- HY-P10236
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Caspase
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Others
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Ac-WEHD-pNA is a colorimetric substrate for caspase 1, 4, 5 and 14, which is utilized to measure the caspase activity .
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- HY-132133
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- HY-P5807
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β-Mammal toxin Cn2
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Sodium Channel
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Neurological Disease
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Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage
sensing domain of voltage gated sodium channels (Nav)
.
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- HY-Z6848
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Sodium Channel
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Neurological Disease
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(R)-(+)-Bupivacaine hydrochloride is a voltage-gated sodium channel inhibitor. (R)-(+)-Bupivacaine hydrochloride can selectively block the voltage-gated sodium channels on nerve cell membranes, inhibit the influx of sodium ions, and thus prevent the generation and conduction of nerve impulses, exerting local anesthetic activity. (R)-(+)-Bupivacaine hydrochloride can be used in research of acute pains .
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- HY-B0114R
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GP 47680 (Standard)
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Reference Standards
Sodium Channel
Apoptosis
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Neurological Disease
Cancer
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Oxcarbazepine (Standard) is the analytical standard of Oxcarbazepine. This product is intended for research and analytical applications. Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .
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- HY-172246
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- HY-13682A
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MTP-PE sodium hydrate; L-MTP-PE sodium hydrate; CGP 19835 sodium hydrate
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NOD-like Receptor (NLR)
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Inflammation/Immunology
Cancer
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Mifamurtide (MTP-PE; CGP 19835) sodium hydrate is the sodium hydrate of mifamurtide. Mifamurtide is a nonspecific immunomodulator that acts by stimulating immune responses by activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and is used as an insulin sensitizer and may also be used in osteosarcoma research .
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- HY-B1798
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Sodium Channel
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Cardiovascular Disease
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Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus .
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- HY-W094708D
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Disodium hydrogen phosphate dihydrate, meets analytical specification of Ph. Eur. BP
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Biochemical Assay Reagents
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Others
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Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research .
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- HY-W990281
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- HY-107695
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FPL 12924AA
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iGluR
Sodium Channel
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Neurological Disease
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Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na + channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively . Remacemide hydrochloride is an anticonvulsant agent .
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- HY-124232
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- HY-161572
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- HY-Y1325E
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sodium acetate trihydrate (Pharmaceutical primary standard, USP)
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Biochemical Assay Reagents
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Others
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Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt that can be used for life science related research .
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- HY-10050
-
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Neurokinin Receptor
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Neurological Disease
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CJ-17493 is a neurokinin-1 (NK1) receptor antagonist, with a Ki of 0.2 nM. CJ-17493 shows moderate affinity for the verapamil-binding site of L-type Ca 2+ channels (IC50 = 164 nM) and site 2 of sodium channels (IC50 = 48 nM). CJ-17493 can be used for the study of neurological diseases .
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- HY-N16421
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- HY-162728
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Opioid Receptor
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Neurological Disease
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RO-76 is a mu opioid receptor (μOR) selective partial agonist. RO-76 binds to μOR-G-protein complex with an EC50 value of 454 nM. RO-76 reduces β-Arrestin-1/2 recruitment. RO-76 shows antinociception activity .
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- HY-W014967
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Biochemical Assay Reagents
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Others
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5-Bromoanthranilonitrile is an organic compound that reacts with sodium hydride in dimethyl sulfoxide to produce a 4-amino-2-(2-aminophenyl)quinazoline analogue .
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- HY-177361
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Sodium Channel
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Cardiovascular Disease
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Zocainone is an antiarrhythmic agent. Zocainone blocks sodium channels in cardiac tissue, stabilizing the cardiac action potential and reducing abnormal electrical activity. Zocainone is promising for research of cardiac arrhythmias .
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- HY-P1219
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β-TRTX-Cj1α
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Sodium Channel
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Neurological Disease
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Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype .
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- HY-17507E
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Proton Pump
Bacterial
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Infection
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S-Pantoprazole (sodium trihydrate) is related to Pantoprazole (HY-17507) that plays an important roles in gastric acid secretion disorder-related diseases, or as proton pump inhibitor .
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- HY-174845
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Sodium Channel
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Neurological Disease
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Nav1.8-IN-20 (Compound I) is an orally active and potent voltage-gated sodium channel Nav1.8 inhibitor with an IC50 value of 14 nM. Nav1.8-IN-20 blocks the generation and conduction of action potentials in peripheral nociceptive neurons, exerting analgesic effects. Nav1.8-IN-20 is promising for research of various pain types such as acute pain, chronic pain, inflammatory pain, and neuropathic pain .
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- HY-P5772
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Sodium Channel
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Neurological Disease
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Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC50 of 0.26 μM .
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- HY-P5943
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- HY-168988
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- HY-P5942
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- HY-111095S3A
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(R)-2-Hydroxypropionic acid-13C-2 sodium; D-Lactic acid-13C-2 sodium
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Isotope-Labeled Compounds
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Others
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D-(-)-Lactic acid- 13C-2 (sodium) is a 13C-labeled D-(-)-Lactic acid (HY-111095). D-(-)-Lactic acid can be used for a variety of biochemical studies.
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- HY-116194
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- HY-111157
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- HY-B0161CR
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(R)-LY248686 (Standard)
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Reference Standards
Sodium Channel
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Neurological Disease
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(R)-Duloxetine (Standard) is the analytical standard of (R)-Duloxetine. This product is intended for research and analytical applications. (R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research .
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- HY-156596A
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Sodium Channel
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Neurological Disease
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Aneratrigine (hydrochloride) is a sodium channel protein type 9 subunit alpha blocker. Aneratrigine (hydrochloride) can be used for neuropathic pain diseases research .
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- HY-P5180
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Sodium Channel
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Neurological Disease
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Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively .
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- HY-106749
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- HY-B0161C
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(R)-LY248686
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Sodium Channel
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Neurological Disease
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(R)-Duloxetine is a isomer of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na + channels. (R)-Duloxetine can be used in pain research .
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- HY-124229
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- HY-106747
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- HY-P5773
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Sodium Channel
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Neurological Disease
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Jingzhaotoxin-34, a 35-residue polypeptide, is a neurotoxin. Jingzhaotoxin-34 inhibits tetrodotoxin-sensitive (TTX-S) sodium currents (IC50 of ~85 nM) while having no significant effects on tetrodotoxin-resistant (TTX-R) sodium currents on rat dorsal root ganglion neurons .
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- HY-156976A
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Calcium Channel
Sodium Channel
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Cardiovascular Disease
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Sulcardine hydrochloride is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine hydrochloride is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine hydrochloride has anti-arrhythmic effects .
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- HY-158979
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Sodium Channel
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Neurological Disease
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Nav1.8-IN-14 (compound 20) is a potent and selective Nav1.8 inhibitor. Nav1.8-IN-14 can be used in the study of pain-related diseases .
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- HY-156976
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Calcium Channel
Sodium Channel
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Cardiovascular Disease
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Sulcardine is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine has anti-arrhythmic effects .
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- HY-168989
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SGLT
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Metabolic Disease
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Olorigliflozin is a sodium glucose co-transporter inhibitor with anti-hyperglycemic effects .
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- HY-162093
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Amyloid-β
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Neurological Disease
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Aβ1–42 aggregation inhibitor 2 (compound 7c) is a potent inhibitor of Aβ1-42 aggregation that plays an important role in Alzheimer's disease research. Aβ1–42 aggregation inhibitor 2 displays excellent antioxidant, metal ions chelating, oxidative stress alleviation, neuroprotective and anti-neuroinflammatory activities .
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- HY-P5177
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- HY-162246
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Sodium Channel
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Cardiovascular Disease
Neurological Disease
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|
Nav1.8-IN-5 (Example 1) is a voltage-gated sodium channel Nav1.8 inhibitor. Nav1.8-IN-5 can be used for Nav1.8-mediated diseases, such as pain and pain-related disorders, as well as cardiovascular diseases (such as atrial fibrillation) research .
|
-
- HY-P5179
-
|
HWTX-I
|
Calcium Channel
Sodium Channel
|
Neurological Disease
|
|
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively .
|
-
- HY-P5770
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Jingzhaotoxin-V, a 29-residue polypeptide, is derived from the venom of the spider Chilobrachys jingzhao. Jingzhaotoxin-V inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 nM and 30.2 nM, respectively. Jingzhaotoxin-V also inhibits Kv4.2 potassium currents expressed in Xenpus Laevis oocytes (IC50 of 604.2 nM) .
|
-
- HY-160208
-
-
- HY-P5771
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .
|
-
- HY-106700
-
|
CM 7857; Penticainide; Propisomide
|
Sodium Channel
|
Cardiovascular Disease
|
|
Pentisomide (CM 7857), a is an orally active antiarrhythmic agent that blocks sodium channels. Pentisomide processes Vaughan-Williams class I (class I) antiarrhythmic actions .
|
-
- HY-B0834R
-
|
(RS)-Indoxacarb (Standard); DPX-JW062 (Standard)
|
Reference Standards
Sodium Channel
|
Neurological Disease
|
|
(±)-Indoxacarb (Standard) is the analytical standard of Indoxacarb. This product is intended for research and analytical applications. Indoxacarb ((±)-Indoxacarb; DPX-JW062) is a broad-spectrum oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. Indoxacarb blocks insect sodium channels in nerve preparations and isolated neurons .
|
-
- HY-181615
-
|
|
Sodium Channel
|
|
|
Nav1.8-IN-22 (Formula I) is a Nav1.8 sodium channel inhibitor. Nav1.8-IN-22 regulates sodium channel activity by directly binding to Nav1.8. Nav1.8-IN-22 is applicable for pain-related research .
|
-
- HY-W094110A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Iron (III) sulfate solution acts as a sodium ion intercalator and sodium storage material. Iron (III) sulfate solution is applicable to research related to the development of sodium-ion battery electrodes .
|
-
- HY-B1798R
-
|
|
Sodium Channel
Reference Standards
|
Cardiovascular Disease
|
|
Tocainide (Standard) is the analytical standard of Tocainide. This product is intended for research and analytical applications. Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus .
|
-
- HY-108505R
-
|
|
Reference Standards
Sodium Channel
|
Neurological Disease
|
|
QX-314 chloride (Standard) is the analytical standard of QX-314 (chloride) (HY-108505). This product is intended for research and analytical applications. QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker .
|
-
- HY-101350R
-
|
|
Sodium Channel
Reference Standards
|
Neurological Disease
|
|
QX-314 (bromide) (Standard) is the analytical standard of QX-314 (bromide) (HY-101350). This product is intended for research and analytical applications. QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker .
|
-
- HY-185335
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Sodium Channel-IN-8 (Example 96) is a voltage-gated sodium channel (NaV1.7) inhibitor.Sodium Channel-IN-8 can be used for the research of pain .
|
-
- HY-W460727
-
|
|
Insecticide
|
Infection
|
|
Boron sodium oxide (tetrahydrate) is an alkaline salt. Boron sodium oxide (tetrahydrate) can be used as an insecticide, a flame retardant, and an agricultural micronutrient .
|
-
- HY-W134304
-
|
|
|
Others
|
|
Sodium metaborate is a borax derivative and boron source that serves as a stabilizer in textile processing and a corrosion inhibitor. Sodium metaborate acts as a precursor to sodium borohydride, a hydrogen storage medium. Sodium metaborate is used in the production of sodium perborate tetrahydrate .
|
-
- HY-109141
-
-
- HY-185333
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Sodium Channel-IN-7 (Example 59) is a NaV1.7 voltage-gated sodium channel inhibitor.Sodium Channel-IN-7 binds to the VSD4 binding pocket of NaV1.7, with reduced interaction with Try1537.Sodium Channel-IN-7 can be used for the research of pain .
|
-
- HY-W740651
-
|
|
Insecticide
Sodium Channel
|
Infection
|
|
Jasmolin II is an insecticide targeting voltage-gated sodium channels in insects. Jasmolin II leads to neuronal hyperexcitation and insect paralysis. Jasmolin II is promising for research of agricultural pests .
|
-
- HY-100616
-
|
cis-1-Aminocyclobutane-1,3-dicarboxylic acid
|
Sodium Channel
|
Neurological Disease
|
|
cis-ACBD is a potent and selective inhibitor of the high-affinity, Na +-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate .
|
-
- HY-P5868
-
|
|
Sodium Channel
|
Neurological Disease
|
|
mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC50 of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .
|
-
- HY-E70073
-
|
Sialidase isoenzyme M2; AuSialidase M2
|
Biochemical Assay Reagents
|
Others
|
|
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .
|
-
- HY-122001
-
|
|
Sodium Channel
|
Neurological Disease
|
|
PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain .
|
-
- HY-112472
-
|
|
Sodium Channel
|
Metabolic Disease
|
|
S3969 is a potent and reversible activator of the human epithelial sodium channel (hENaC). The apparent EC50 for S3969 activation of hENaC is 1.2 μm .
|
-
- HY-B0114
-
|
GP 47680
|
Sodium Channel
Apoptosis
|
Neurological Disease
Cancer
|
|
Oxcarbazepine is a sodium channel blocker . Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines . Anti-cancer and anticonvulsant effects .
|
-
- HY-10449A
-
|
TS 071 hydrate
|
SGLT
|
Metabolic Disease
|
|
Luseogliflozin (TS 071) hydrate is a selective potent and orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor with an IC50 of 2.26 nM. Luseogliflozin hydrate can be used for the research of type 2 diabetes mellitus (T2DM) .
|
-
- HY-100973
-
|
ADP ribose
|
TRP Channel
Autophagy
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD +) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca 2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy .
|
-
- HY-P5184
-
|
HNTX-IV
|
Sodium Channel
|
Neurological Disease
|
|
Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .
|
-
- HY-175728
-
|
|
Potassium Channel
Sodium Channel
Calcium Channel
|
Metabolic Disease
|
|
VU6032735 is a potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 values of 165 nM (hSLO3) and 730 nM (mSLO3). VU6032735 also inhibits sodium channel and L-type calcium channel VU6032735 can sustain high tissue exposure in the fertilized oviduct. VU6032735 can be used for the research of contraception .
|
-
- HY-114918
-
|
|
TSH Receptor
|
Endocrinology
|
|
MS438 is a potent thyrotropin receptor (TSHR) agonist with an EC50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice .
|
-
- HY-N3990
-
|
(-)-Hardwickiic acid; (-)-Hardwikiic acid
|
Sodium Channel
Parasite
|
Infection
Neurological Disease
|
|
Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases .
|
-
- HY-114961
-
|
15-epi PGA1
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
15-epi Prostaglandin A1 (15-epi PGA1) is the 15(R) stereoisomer of PGA1. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive models .
|
-
- HY-100973AR
-
|
ADP ribose sodium (Standard)
|
Reference Standards
TRP Channel
Autophagy
|
Metabolic Disease
Endocrinology
Cancer
|
|
Adenosine 5′-diphosphoribose (sodium) (Standard) is the analytical standard of Adenosine 5′-diphosphoribose (sodium). This product is intended for research and analytical applications. Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .
|
-
- HY-127004
-
|
RGH-5002
|
Sodium Channel
|
Others
|
|
Silperisone hydrochloride is an organosilicone compound similar to tolperisone that has centrally acting muscle relaxant properties. Silperisone (hydrochloride) is a sodium channel protein type 2 alpha channel blocker that blocks sodium and calcium channels in cells, reduces muscle cell excitability and contraction, reduces peripheral tone, and acts as a muscle relaxant and peripheral vascular dilator. Silperisone (hydrochloride) is used to study recurrent painful myoclonus due to spinal cord injury, abnormal hypertonia due to cerebrovascular disease, myotonia symptoms, pyramidal tonia syndrome, multiple sclerosis myospasm, and myelitis .
|
-
- HY-161272
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Nav1.8-IN-6 (Compound 2j) is a novel pyridinone amide Nav1.8 channel inhibitor. The IC50 values in the resting state and semi-activated state are 513.33 and 471.81 nM, respectively. Nav1.8-IN-6 has analgesic activity .
|
-
- HY-P3777
-
|
|
Potassium Channel
|
Neurological Disease
|
|
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .
|
-
- HY-117494
-
|
NSC 44626
|
Sodium Channel
Chloride Channel
|
Cardiovascular Disease
|
|
Flumethiazide (NSC 44626) is an orally active diuretic agent. Flumethiazide has marked diuretic and natruretic effects with significant effects on Sodium, Chloride and water but not on potassium excretion. Flumethiazide can be used for cardiac diseases like essential hypertension research .
|
-
- HY-144287
-
|
|
Glucokinase
Sodium Channel
|
Metabolic Disease
|
|
Glucokinase activator 3 is an orally active Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 inhibits hERG channel and sodium channel in patch clamp assays. Glucokinase activator 3 exhibits high efficacy in reducing blood glucose in diet-induced obese (DIO) mice. Glucokinase activator 3 has the potential for the research of type 2 diabetes .
|
-
- HY-100973A
-
|
ADP ribose sodium
|
TRP Channel
Autophagy
|
Metabolic Disease
Endocrinology
Cancer
|
|
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD +) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca 2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .
|
-
- HY-148410C
-
|
STK-001 negative control
|
Sodium Channel
|
Neurological Disease
|
|
Zorevunensen (STK-001) negative control is the negative control form of Zorevunensen (HY-148410). Zorevunensen is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav1.1 protein. Zorevunersen is used for the study of Dravet syndrome .
|
-
- HY-108622
-
|
Daxalipram
|
Phosphodiesterase (PDE)
Interleukin Related
IFNAR
|
Inflammation/Immunology
|
|
Mesopram (Daxalipram) is an orally active phosphodiesterase (PDE) 4 inhibitor. Mesopram inhibits the synthesis of proinflammatory cytokines TNF-α and IFN-γ. Mesopram demonstrates efficacy in ameliorating Dextran sulfate sodium (DSS) (HY-116282C)-induced murine colitis. Mesopram can be used for the study of chronic inflammatory diseases .
|
-
- HY-162347
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine (HY-N6691)-induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity .
|
-
- HY-N6691R
-
|
3-Veratroylveracevine (Standard)
|
Reference Standards
Sodium Channel
|
Neurological Disease
|
|
Veratridine (Standard) is the analytical standard of Veratridine. This product is intended for research and analytical applications. Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow .
|
-
- HY-16952A
-
|
(±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate
|
Calcium Channel
|
Cardiovascular Disease
|
|
Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca + channel antagonist and Na +, K + channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na +/Ca2 + exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders .
|
-
- HY-N6691
-
|
3-Veratroylveracevine
|
Sodium Channel
|
Neurological Disease
|
|
Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow .
|
-
- HY-147423
-
|
NBI-921352; XEN901
|
Sodium Channel
|
Neurological Disease
|
|
Zandatrigine (NBI-921352; XEN901) is a selective, orally active, voltage-gated sodium channel NaV1.6/SCN8A inhibitor that can penetrate the blood-brain barrier. Zandatrigine inhibits sodium influx by non-covalently binding to the VSD4 structure of NaV1.6, blocking the persistent and resuscitative currents under pathological conditions. Zandatrigine can reduce neuronal hyperexcitability and reduce epileptic seizures. Zandatrigine is 134-756-fold selective for other isoforms such as NaV1.1 and NaV1.2, and has minimal effect on NaV1.1 expressed by inhibitory interneurons. Zandatrigine can be used to study NaV1.6-mediated neuroexcitability diseases such as SCN8A-related developmental epileptic encephalopathy (SCN8A-DEE) and adult focal epilepsy .
|
-
- HY-P992040
-
|
16G2
|
Interleukin Related
|
Others
|
|
HAIL-12 is anan anti-human Interleukin-12 (IL-12p70) monoclonal antibody. HAIL-12 inhibits IL-12-mediated proliferation of T cells from human peripheral blood mononuclear cells .
|
-
- HY-108502
-
|
|
Sodium Channel
|
Cardiovascular Disease
|
|
KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na + current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo .
|
-
- HY-P1218
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .
|
-
- HY-177763
-
|
|
TRP Channel
|
Neurological Disease
|
|
TRPM8 receptor agonist-1 (Example 81) is a TRPM8 receptor agonist. TRPM8 receptor agonist-1 can trigger the inward flow of calcium, sodium and other ions within the cell, causing the cell membrane to depolarize and triggering an action potential. TRPM8 receptor agonist-1 can activate signals related to the swallowing reflex and can be used for the research of oropharyngeal dysphagia .
|
-
- HY-122439
-
|
Mevinolinic acid; MSD803
|
HMG-CoA Reductase (HMGCR)
Drug Metabolite
|
Metabolic Disease
|
|
Lovastatin acid (Mevinolinic acid; MSD803), an active metabolite of Lovastatin (HY-N0504), is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM. Lovastatin acid acts as a competitive inhibitor with respect to substrate HMG-CoA, interfering cholesterol synthesis. Lovastatin acid can be used for the research of hypercholesterolemia .
|
-
- HY-177311
-
|
|
Sodium Channel
|
Metabolic Disease
|
|
NVP-QBE170 is a selective Epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. NVP-QBE170 potently inhibits ENaC function in HBECs and shows a longer duration of action. NVP-QBE170 significantly attenuates ENaC activity in the airways of guinea pig models. NVP-QBE170 can be used for hyperkalaemia research .
|
-
- HY-11079
-
|
|
Sodium Channel
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter .
|
-
- HY-P1218A
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .
|
-
- HY-130187A
-
|
|
Bacterial
|
Infection
|
|
Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively .
|
-
- HY-P1218B
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Phrixotoxin 3-NH2 TFA is a derivative of Phrixotoxin 3 TFA (HY-P1218A). Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .
|
-
- HY-178494
-
|
|
Sodium Channel
Potassium Channel
|
Neurological Disease
|
|
Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC50 of 0.49 μM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease .
|
-
- HY-109542
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney .
|
-
- HY-123833
-
|
|
Sodium Channel
|
Others
|
|
PF-05661014, a desmethyl analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing inactivated channels via interaction with D4 VSD. PF-05661014 can be used for research of sodium channel modulation .
|
-
- HY-Z6449
-
|
|
Adrenergic Receptor
|
Neurological Disease
|
|
Phenylephrine hydrochlorid is an α1-adrenergic receptor agonist. As a sympathomimetic agent, Phenylephrine hydrochlorid exerts similar effects to epinephrine and ephedrine. Phenylephrine hydrochlorid induces vasoconstriction and increases perfusion pressure .
|
-
- HY-P5164
-
|
|
Sodium Channel
|
Neurological Disease
|
|
GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 μM, 0.23 μM, 0.77 μM, 1.29 μM, 0.63 μM and 0.37 μM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively . GrTx1 can be used for neurological disease research .
|
-
- HY-109542R
-
|
|
Biochemical Assay Reagents
Reference Standards
|
Metabolic Disease
|
|
Cyclopenthiazide (Standard) is the analytical standard of Cyclopenthiazide. This product is intended for research and analytical applications. Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney .
|
-
- HY-135000
-
|
DcSTX; DecarbamoylSTX
|
Endogenous Metabolite
Drug Metabolite
|
Neurological Disease
|
|
Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na + channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning .
|
-
- HY-W250727
-
|
6-(p-Tolylamino)naphthalene-2-sulfonate sodium
|
Fluorescent Dye
|
Others
|
|
TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .
|
-
- HY-19463
-
|
|
Sodium Channel
|
Cardiovascular Disease
|
|
F 15845 hydrobromide is a highly effective persistent sodium current blocker. F 15845 hydrobromide is also a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 hydrobromide can be used for the research of myocardium functional impairment .
|
-
- HY-17612
-
|
NW-3509
|
Sodium Channel
|
Neurological Disease
|
|
Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness .
|
-
- HY-150612
-
|
|
p38 MAPK
|
Cancer
|
|
(R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis .
|
-
- HY-B1704
-
-
- HY-135478A
-
|
NCC1048 free base
|
Calcium Channel
Sodium Channel
|
Neurological Disease
|
|
LY393615 (NCC1048) free base is a novel neuronal Ca 2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 free base has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research .
|
-
- HY-B1704A
-
|
|
Monoamine Transporter
Sodium Channel
|
Neurological Disease
|
|
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .
|
-
- HY-N18023
-
|
|
Others
|
Others
|
|
Kaempferol-3-O-β-D-Glucose-7-O-β-D-Gentianoside is a kaempferol glycoside found in the seeds of Lepidium apetalum Willd. Kaempferol-3-O-β-D-Glucose-7-O-β-D-Gentianoside shows no obvious inhibitory effect on Sodium oleate (HY-N1446B)-induced triglyceride overloading in liver cells .
|
-
- HY-B1704R
-
|
|
Monoamine Transporter
Sodium Channel
|
Neurological Disease
|
|
Nisoxetine (Standard) is the analytical standard of Nisoxetine. This product is intended for research and analytical applications. Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .
|
-
- HY-17612A
-
|
NW-3509 hydrochloride
|
Sodium Channel
|
Neurological Disease
|
|
Evenamide hydrochloride is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 μM) for the research of schizophrenia. Evenamide hydrochloride shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness .
|
-
- HY-122376
-
|
D-Trans-Allethrin; Esbiol
|
Environmental Pollutants
Sodium Channel
|
Neurological Disease
|
|
S-Bioallethrin (D-Trans-Allethrin) is a pyrethroid insecticide. S-Bioallethrin disrupts nerve function by modifying the gating kinetics of transitions between the conducting and nonconducting states of voltage-gated sodium channels. S-Bioallethrin also causes inhibition of lymphocyte proliferation and induces histamine release from human basophils .
|
-
- HY-19463A
-
|
|
Sodium Channel
|
Cardiovascular Disease
|
|
F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment .
|
-
- HY-135478
-
|
NCC1048
|
Calcium Channel
Sodium Channel
|
Neurological Disease
|
|
LY393615 (NCC1048) is a novel neuronal Ca 2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research .
|
-
- HY-103311
-
|
Ammoniated ruthenium oxychloride
|
Calcium Channel
|
Cardiovascular Disease
|
|
Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker .
|
-
- HY-P990163
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis .
|
-
- HY-W007087
-
|
|
GABA Receptor
|
Metabolic Disease
|
|
Valerate sodium is the sodium salt of valeric acid, a short-chain fatty acid, and exhibits oral activity. Valerate sodium reduces binge ethanol intake and decreases blood ethanol concentration in mice, while also exerting anxiolytic effects. Valerate sodium increases GABA levels, regulates epigenetics and alters gut microbiome function. Valerate sodium can be used in research related to excessive alcohol consumption .
|
-
- HY-W094110
-
|
|
Environmental Pollutants
Biochemical Assay Reagents
|
Others
|
|
Iron (III) sulfate is a stable rhombohedral NASICON compound. Iron (III) sulfate can serve as a sodium ion intercalation host, enabling sodium ion intercalation and deintercalation via a single-phase mechanism relying on the Fe 2+/Fe 3+ redox couple. Iron (III) sulfate exhibits reversible electrochemical behavior and moderate polarization in cyclic voltammetry tests, and its charge transfer resistance changes during charge-discharge cycles. Iron (III) sulfate possesses a high redox potential, excellent rate capability, and long-cycle stability .
|
-
- HY-183646
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Nav1.8-IN-23 (Compound 4) is a Nav1.8 voltage-gated sodium channel inhibitor with a pIC50 of 6.1. Nav1.8-IN-23 can be used for the research of pain-related diseases .
|
-
- HY-N19425
-
|
|
Apoptosis
|
Metabolic Disease
|
|
Pulsatilloside A is an anti-Apoptotic agent. Pulsatilloside A can be isolated from the roots of P. chinensis. Pulsatilloside A exerts a protective effect against apoptosis induced by sodium cyanide and glucose deprivation .
|
-
- HY-12546
-
-
- HY-E70558
-
|
|
5 alpha Reductase
|
Metabolic Disease
|
5α-reductase, Rat (Sprague-Dawley) Liver is an enzyme involved in steroid metabolism and participates in the androgen metabolic pathway. 5α-reductase, Rat (Sprague-Dawley) Liver catalyzes the conversion of testosterone to 5α-dihydrotestosterone (DHT). DHT plays important roles in the development of male sex organs, hair growth, prostate function, and other aspects .
|
-
- HY-B1549
-
-
- HY-B2021
-
|
|
Insecticide
|
Neurological Disease
|
|
τ-Fluvalinate is an insecticide and in-hive miticide, with its mechanism involving interfering with nervous systems. τ-Fluvalinate binds to the open state of Varroa destructor (VdNaV1) and Apis mellifera (AmNaV1) voltage-dependent sodium channels, with EC50 values of 160 nM and 60 nM respectively. τ-Fluvalinate has higher affinity for AmNaV1, which causes sublethal toxicity to honeybees. τ-Fluvalinate can be applied for research on Varroa destructor infestation in honeybee colonies .
|
-
- HY-111662
-
|
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis .
|
-
- HY-124470
-
|
|
Others
|
Cardiovascular Disease
|
|
Amisometradine is an orally active aminouracil diuretic with a diuretic potency approximately 40% that of Mersalyl (HY-108868) (when administered intramuscularly). Amisometradine exerts its effects by promoting the excretion of sodium, chloride and a small amount of potassium, exhibits significant therapeutic effects in heart failure models, and has good tolerance with long-term administration. Compared with drugs of the same class, Amisometradine causes fewer gastrointestinal reactions; its minor side effects mainly include nausea, vomiting, diarrhea, tinnitus and deafness, and are usually not accompanied by proteinuria or abnormalities in blood and urine indicators. Amisometradine is an important tool for the study of heart failure and related diuretic mechanisms .
|
-
- HY-W009022
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Diantipyrylmethane is a chromogenic reagent commonly used for the determination of the contents of metals such as Au (III), Ti (IV), Ir, Fe (III), molybdenum, neodymium, U (IV), iridium, platinum and rhenium via spectrophotometry and extraction photometry. Diantipyrylmethane can also form a fluorescent complex with Er (III) ions, which is applied to the determination of erbium .
|
-
- HY-B2081
-
|
W-2900A
|
Others
|
Cardiovascular Disease
Metabolic Disease
|
|
Etozolin (W-2900A) is a diuretic agent. Etozolin inhibits fluid and electrolyte reabsorption in the loop of Henle. Etozolin can be used in research of congestive heart failure, hypertension and edema .
|
-
- HY-B2081A
-
|
W-2900A hydrochloride
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
|
Etozolin hydrochloride is a diuretic agent. Etozolin hydrochloride inhibits fluid and electrolyte reabsorption in the loop of Henle. Etozolin hydrochloride can be used in research of congestive heart failure, hypertension and edema .
|
-
- HY-186131
-
|
|
Drug Derivative
HBV
|
Infection
|
|
Val-CDCA is a chenodeoxycholate (CDCA) and C-24 L-Valine (HY-N0717) conjugate. Val-CDCA inhibits taurocholate uptake in human NTCP-stably transfected HEK293 cells. Val-CDCA can be used for HBV infection .
|
-
- HY-P1220
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain .
|
-
- HY-P1220A
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain .
|
-
- HY-164690A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Nicotinamide-guanine dinucleotide sodium, a NAD sodium (HY-B0445A) analog, is an oxidized forms of nicotinamide guanine dinucleotide. Nicotinamide-guanine dinucleotide sodium serves as coenzymes for alcohol dehydrogenase (ADH) in vitro .
|
-
- HY-P1604
-
ATX-II
1 Publications Verification
|
Sodium Channel
|
Cardiovascular Disease
Inflammation/Immunology
|
|
ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .
|
-
- HY-P1604A
-
|
|
Sodium Channel
|
Cardiovascular Disease
Inflammation/Immunology
|
|
ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .
|
-
- HY-P11363
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
(Des-Asp1,Ile8)-Angiotensin II is a peptide related to angiotensin II. (Des-Asp1,Ile8)-Angiotensin II can be used for studying the interaction between angiotensin II and its receptors .
|
-
- HY-114659
-
-
- HY-119521
-
|
KOE-1173
|
Sodium Channel
|
Cardiovascular Disease
Neurological Disease
|
|
Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
|
-
- HY-108506
-
|
BIA 2-005; GP 47779
|
Sodium Channel
|
Neurological Disease
|
|
Licarbazepine (BIA 2-005; GP 47779) is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects .
|
-
- HY-N2877
-
|
|
Potassium Channel
Sodium Channel
Na+/K+ ATPase
Calcium Channel
Apoptosis
|
Neurological Disease
Cancer
|
|
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W +/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways .
|
-
- HY-108506R
-
|
BIA 2-005 (Standard); GP 47779 (Standard)
|
Reference Standards
Sodium Channel
|
Neurological Disease
|
|
Licarbazepine (Standard) is the analytical standard of Licarbazepine. This product is intended for research and analytical applications. Licarbazepine (BIA 2-005; GP 47779) is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects .
|
-
- HY-107929
-
|
Poly(styrenesulfonic acid) calcium salt
|
Potassium Channel
|
Metabolic Disease
|
|
Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) is an orally active potassium-lowering agent. Calcium polystyrene sulfonate binds potassium in the distal colon in exchange for Ca 2+. Calcium polystyrene sulfonate can be used for the research of hyperkalemia in chronic kidney disease .
|
-
- HY-100345
-
|
|
TRP Channel
|
Neurological Disease
Cancer
|
|
AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (NaV) .
|
-
- HY-W134328
-
|
Dextran blue (MW 2000000)
|
Biochemical Assay Reagents
|
Others
|
|
Blue dextran (Dextran blue) (MW 2000000) is a high-molecular-weight long-chain polymer of D-glucose. Blue dextran (MW 2000000) serves as an important model macromolecular drug and molecular weight estimation marker, and can be used as a standard for gel permeation chromatography. The release of Blue dextran (MW 2000000) from alginate microspheres is regulated by preparation conditions; its release rate in a pH 6.8 environment is significantly faster than that in pH 1.2, and it exhibits release characteristics close to zero-order kinetics under this condition .
|
-
- HY-W016562
-
-
- HY-106718
-
|
|
Sodium Channel
|
Cardiovascular Disease
|
|
Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel). Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (Vmax) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD). Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias .
|
-
- HY-A0081
-
|
|
Dopamine Receptor
SARS-CoV
Sodium Channel
|
Neurological Disease
Cancer
|
|
Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .
|
-
- HY-119980B
-
|
|
Dopamine Receptor
Sodium Channel
SARS-CoV
|
Neurological Disease
Cancer
|
|
Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .
|
-
- HY-105084
-
|
|
Sodium Channel
Calcium Channel
|
Infection
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Lubeluzole is the S-isomer of benzothiazole derivative. Lubeluzole can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole exhibits anti-ischemic and neuroprotective effects. Lubeluzole also shows anti-bacterial and anti-diarrheal potential. Lubeluzole can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .
|
-
- HY-A0093
-
|
KOE-1173 hydrochloride
|
Sodium Channel
|
Cardiovascular Disease
Neurological Disease
|
|
Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
|
-
- HY-14945
-
|
GSK189075
|
SGLT
|
Metabolic Disease
|
|
Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with Ki values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models .
|
-
- HY-76562
-
-
- HY-119980
-
|
|
Sodium Channel
Dopamine Receptor
SARS-CoV
|
Infection
Neurological Disease
Cancer
|
|
Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .
|
-
- HY-105084A
-
|
|
Sodium Channel
Calcium Channel
|
Cardiovascular Disease
Infection
Neurological Disease
Cancer
|
|
Lubeluzole dihydrochloride is the dihydrochloride salt of Lubeluzole (HY-105084). Lubeluzole dihydrochloride is the S-isomer of benzothiazole derivative. Lubeluzole dihydrochloride can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole dihydrochloride exhibits anti-ischemic and neuroprotective effects. Lubeluzole dihydrochloride also shows anti-bacterial and anti-diarrheal potential. Lubeluzole dihydrochloride can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole dihydrochloride can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole dihydrochloride can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .
|
-
- HY-A0093R
-
|
KOE-1173 hydrochloride (Standard)
|
Sodium Channel
Reference Standards
|
Cardiovascular Disease
Neurological Disease
|
|
Mexiletine (hydrochloride) (Standard) is the analytical standard of Mexiletine (hydrochloride). This product is intended for research and analytical applications. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .
|
-
- HY-120321
-
|
|
Mineralocorticoid Receptor
Carbonic Anhydrase
|
Cardiovascular Disease
|
|
DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure .
|
-
- HY-W096983
-
|
Dodecyltrimethylammonium chloride,for IPC,≥99%
|
Environmental Pollutants
Biochemical Assay Reagents
|
Others
|
|
DTAC (Dodecyltrimethylammonium chloride), for IPC, ≥99% is a quaternary ammonium cationic surfactant. DTAC, for IPC, ≥99% can form micelles in aqueous media, which interact with and encapsulate Diclofenac sodium (HY-15037) molecules; the micellization process is entropy-driven at lower temperatures and enthalpy-driven at higher temperatures .
|
-
- HY-141582
-
|
N-Stearoyl phytosphingosine
|
JNK
NF-κB
Interleukin Related
TNF Receptor
|
Inflammation/Immunology
|
|
Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin .
|
-
- HY-W968308
-
|
|
Amino Acid Derivatives
|
Metabolic Disease
|
|
H-Gly-D-Ala-OH is a dipeptide containing D-amino acid. H-Gly-D-Ala-OH can be specifically hydrolyzed by renal dipeptidase, which acts on peptide segments with a D-amino acid at the carboxyl terminus. H-Gly-D-Ala-OH enables highly specific detection of renal dipeptidase activity without interference from other serum or urine aminopeptidases. When used in combination with low-dose Sodium nitrite (HY-N11218), H-Gly-D-Ala-OH inhibits the initial spore growth of Clostridium botulinum in pork homogenate, whereas it has no such effect on its own. H-Gly-D-Ala-OH can be used in research related to chronic renal failure, diabetes mellitus and botulism .
|
-
- HY-W583729
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DL-Poly (lactic acid) is a biodegradable poly (α-hydroxy acid) matrix and a coating material for controlled drug release. DL-Poly (lactic acid) is classified as a drug release retardant, which degrades into natural lactic acid monomers, an intermediate product of carbohydrate metabolism, enabling complete drug delivery that lasts for several weeks. Its drug release rate is affected by the pH of the surrounding environment .
|
-
- HY-181875
-
|
|
LPL Receptor
|
Inflammation/Immunology
|
|
S1PR1/S1PR5 agonist-1 (Compound 19) is an orally active S1PR1 and S1PR5 agonist with EC50 values of 40.0 and 22.9 nM, respectively. S1PR1/S1PR5 agonist-1 binds to key residues of S1PR1 to mediate agonistic activity. S1PR1/S1PR5 agonist-1 alleviates colitis pathological changes in DSS-induced mouse models and exerts minimal effects on mouse heart rate. S1PR1/S1PR5 agonist-1 can be used for the research of inflammatory bowel disease .
|
-
- HY-179634
-
|
|
SARS-CoV
HIV
Enterovirus
Angiotensin-converting Enzyme (ACE)
RSV
Filovirus
|
Infection
|
|
ASF-006 sodium, a tetrapodal tryptophan derivative, is a potent viral invasion inhibitor. ASF-006 sodium shows potent antiviral activity against different SARS-CoV-2 Omicron variants but not against the ancestral SARS-CoV.2 strain (Wuhan-Hu-1). ASF-006 sodium competitively inhibits receptor-binding domain (RBD)-ACE2 binding via an allosteric mechanism. ASF-006 sodium inhibits Omicron BA.1, Omicron XBB.1.5, respiratory syncytial virus (RSV) and Ebola virus infection with IC50s of 0.02 μM, 0.3 μM, 1.52 μM and 0.2 μM, respectively. ASF-006 sodium inhibits cell entry of both HIV and enterovirus A71[1].
|
-
- HY-N2511
-
|
|
Cholinesterase (ChE)
Phosphatase
|
Infection
Neurological Disease
|
|
Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC50 values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity .
|
-
- HY-D2481
-
|
APG-2 (TMA)
|
Fluorescent Dye
|
Neurological Disease
|
|
Asante potassium green-2 (APG-2) TMA is a cell-impermeable K + (potassium ion) fluorescent indicator that produces a fluorescent response to changes in extracellular potassium ion concentration. Its excitation/emission maxima are 525/545 nm , respectively.
|
-
- HY-66012A
-
|
Proxymetacaine
|
Sodium Channel
|
Neurological Disease
|
|
Proparacaine (Proxymetacaine) is a local anesthetic. Proparacaine blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine is used in research related to cataracts .
|
-
- HY-34409
-
|
3-Methylbut-2-en-1-al
|
Drug Intermediate
|
Others
|
|
3-Methyl-2-butenal (3-Methylbut-2-en-1-al) is an enone aldehyde that occurs in hops (Humulus lupulus L.) .
|
-
- HY-N16021
-
|
|
Toll-like Receptor (TLR)
Cdc42-binding kinase
Galectin
|
Inflammation/Immunology
|
|
4A-MPLA ammonium is an orally active TLR4 agonist. 4A-MPLA ammonium induces TLR4 endocytosis dependent on Cdc42 and galectin-3, triggering TRIF-mediated signaling and sustained IFN-β production. 4A-MPLA ammonium promotes lipid droplet formation, upregulates interferon-stimulated genes and type I IFN signaling genes, downregulates lysosome/phagosome function genes, and modulates tolerogenic dendritic cell function. 4A-MPLA ammonium can be used for the research of colitis .
|
-
- HY-181485
-
|
|
GPR68
TNF Receptor
Interleukin Related
|
Inflammation/Immunology
|
|
GPR68 antagonist 1 is a GPR68 antagonist with an IC50 of 81 nM. GPR68 antagonist 1 inhibits the mouse GPR68-mediated cAMP signaling pathway with an IC50 of 179 nM. GPR68 antagonist 1 alleviates disease symptoms in a dextran sulfate sodium (DSS) (HY-116282C)-induced mouse model of inflammatory bowel disease. GPR68 antagonist 1 is applicable to research related to inflammatory bowel disease .
|
-
- HY-181821
-
|
|
Parasite
Na+/K+ ATPase
|
Infection
|
|
MMV1581361 is a PfATP4 inhibitor and an orally active, transmission-blocking agent with nanomolar activity against Plasmodium falciparum blood-stage isolates. MMV1581361 disrupts sodium ion (Na +) homeostasis in Plasmodium falciparum. MMV1581361 inhibits male gamete exflagellation, reduces oocyst intensity, and blocks transmission of Plasmodium falciparum. MMV1581361 demonstrates efficacy in the humanized Plasmodium falciparum NOD scid IL2Rγ null mouse model. MMV1581361 can be used for the research of malaria .
|
-
- HY-183652
-
|
|
5-HT Receptor
Sodium Channel
|
Neurological Disease
|
|
5-HT2C-agonist-14 is a 5-HT2C receptor agonist with an EC50 of 2.9 μM against human receptors. It also acts as a voltage-gated sodium channel inhibitor and is a blood-brain barrier permeable compound. 5-HT2C-agonist-14 elevates seizure threshold, suppresses seizure progression and alleviates pain-related behaviors. It can be used in the research of epilepsy and pain-related diseases .
|
-
- HY-N2026A
-
|
Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium
|
Estrogen Receptor/ERR
|
Cardiovascular Disease
Neurological Disease
|
|
Propylparaben sodium is an orally active weak estrogen receptor agonist. Propylparaben sodium regulates the PI3K-AKT and JNK signaling pathways, induces oxidative stress, and alters the estrous cycle, hormone levels and ovarian reserve function. Propylparaben sodium inhibits the growth of antral follicles and alters the accumulation of steroid hormones in follicle culture media. Propylparaben sodium can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury[1][2][3][4][5].
|
-
- HY-179445
-
|
|
Sodium Channel
|
Neurological Disease
Inflammation/Immunology
|
|
Nav1.7-IN-20 (Compound 3AG) is an orally active Nav1.7 channel inhibitor with an IC50 of 3.1 μM. Nav1.7-IN-20 demonstrates analgesic efficacy in a complete Freund's adjuvant (CFA) inflammatory pain model. Nav1.7-IN-20 can be used for pain research .
|
-
- HY-157786
-
|
|
Sodium Channel
|
Neurological Disease
|
|
XPC-5462 is a selective NaV1.6/1.2 inhibitor, with an IC50 of 0.0103 μM against hNaV1.6, 0.0137 μM against mNaV1.6, and 0.0109 μM against hNaV1.2. XPC-5462 significantly reduces epileptiform discharges. XPC-5462 is applicable for epilepsy-related research .
|
-
- HY-147377
-
-
- HY-N17493
-
|
|
Others
|
Others
|
|
Spinosic acid A is a triterpene sapogenin. Spinosic acid A is found in Randia spinosa(Thunb.) Poir. .
|
-
- HY-17355B
-
|
(R)-Pramipexole; R-(+)-Pramipexole; KNS-760704
|
PINK1/Parkin
Glutathione Peroxidase
Sodium Channel
ATP Synthase
NOD-like Receptor (NLR)
Mitophagy
Ferroptosis
Autophagy
Apoptosis
Reactive Oxygen Species (ROS)
|
Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
|
|
Dexpramipexole ((R)-Pramipexole) is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more .
|
-
- HY-107835
-
|
FCR 2769
|
Environmental Pollutants
Apoptosis
Bcl-2 Family
Parasite
Insecticide
|
Infection
Cancer
|
|
Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide . Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer .
|
-
- HY-168366
-
|
|
Opioid Receptor
|
Neurological Disease
|
|
R-6890 is a Brorphine-related opioid receptor antagonist that exhibits differential binding activities toward rat opioid receptors (IC50=4.6 nM (0.05 M Tris; pH 7.4) and 170 nM (0.05 M Tris+0.1 M NaCl)). R-6890 displaces bound labeled opioids from receptors, and its binding affinity is affected by environmental factors, decreasing in the presence of NaCl. R-6890 crosses the blood-brain barrier (BBB) and exerts analgesic effects in the warm water-induced tail-flick reflex model of male Wistar rats .
|
-
- HY-182548
-
|
|
GABA Receptor
Sodium Channel
iGluR
|
Cardiovascular Disease
Neurological Disease
|
|
BTS 72664 is a broad-spectrum, non-sedating, orally effective anticonvulsant. Its anticonvulsant effect mainly arises from enhancing GABAA receptor (GABAA receptor)-mediated chloride channel currents, while it exerts weak blocking effects on Na + channels (Ki = 350 μM) and NMDA receptors (NMDA receptor) (IC50 = 43 μM). BTS 72664 prevents the elevation of extracellular glutamate, glycine and serine concentrations in neurons, reduces cerebral infarct size, promotes functional recovery, prevents multiple types of epileptic seizures, and has low sedative potential. BTS 72664 can be used for the research of epilepsy, stroke and migraine .
|
-
- HY-P2799A
-
|
CK, CPK, Creatine Phosphokinase
|
Endogenous Metabolite
Creatine Kinase
|
Cardiovascular Disease
|
|
Creatine Kinase (CPK/CK), Bovine Heart (CK) is a creatine kinase derived from bovine heart. Creatine Kinase (CPK/CK), Bovine Heart catalyzes the reversible phosphate transfer reaction between phosphocreatine and ADP, and is widely used in myocardial energy metabolism research and quality control of clinical biochemical tests .
|
-
- HY-183566
-
|
|
Sodium Channel
|
Neurological Disease
|
|
MK-5661 is an orally potent NaV1.8 voltage-gated sodium channel inhibitor with an EC50 of 4.3 nM. MK-5661 selectively inhibits peripheral nociceptive signaling mediators. MK-5661 reduces capsaicin-induced spontaneous nociceptive behaviors in humanized rats and attenuates capsaicin-induced skin flushing responses in rhesus monkeys. MK-5661 is applicable for pain-related research .
|
-
- HY-D2482
-
|
APG-1 AM
|
Fluorescent Dye
|
Neurological Disease
|
|
Asante potassium green-1 AM (APG-1 AM) is a cell-permeable K +-sensitive fluorescent indicator and potassium ion indicator that exhibits minimal interference from Na + and pH at physiologically relevant intracellular levels. Asante potassium green-1 AM enables non-invasive monitoring and quantitative analysis of intracellular potassium ion concentration (ᵢ) . Its excitation/emission maxima are 525/545 nm, respectively.
|
-
- HY-A0079
-
|
Amethocaine
|
Sodium Channel
Calcium Channel
|
Neurological Disease
|
Tetracaine (Amethocaine) is a sodium channel inhibitor and ryanodine receptor (RyR) inhibitor. Tetracaine blocks sodium conduction across nerve cell membranes, preventing rapid sodium ion influx and depolarization. Tetracaine exhibits biphasic effects on spontaneous sarcoplasmic reticulum Ca 2+ release in Ca 2+-overloaded ventricular myocytes, and increases sarcoplasmic reticulum Ca 2+ load. Tetracaine can be used in research related to eye diseases .
|
-
- HY-183709
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Nav1.8-IN-24 is a voltage-gated sodium channel Nav1.8 inhibitor with pIC50 values of 7.4 (resting state) and 7.5 (inactivated state), and it exhibits high selectivity for NaV1.1-1.7 subtypes. Nav1.8-IN-24 possesses in vitro safety and drug interaction profiles. Nav1.8-IN-24 can be used for the research of acute pain and chronic neuropathic pain .
|
-
- HY-181706
-
|
|
Insecticide
|
Infection
|
|
Insecticidal agent 29 is a pyrethroid incorporating a pyridine heterocycle and insecticide. Insecticidal agent 29 exhibits insecticidal activity against Culex pipiens Pallens larvae, Aphis laburni Kaltenbach, and aphids. Insecticidal agent 29 shows inactivity against Tetranychus cinnabarinus Boisduval .
|
-
- HY-172754
-
|
|
Fluorescent Dye
|
Cancer
|
|
ICAAc is a solvatochromic fluorophore with reduced basicity. ICAAc demonstrates significant solvatochromic behavior across solvents of varying polarity, with a large dipole moment difference and low quantum yield in water, making it a tunable solvatochromic fluorophore. ICAAc enables pH sensing via UV-vis/fluorescence detection and in microenvironments including sodium lauryl sulfate micelle Stern layers. ICAAc acts as a supravital cell stain for epifluorescence imaging of live cancer cells .
|
-
- HY-106501A
-
|
Goe 4704 hydrochloride
|
Potassium Channel
|
Cardiovascular Disease
|
|
Asocainol hydrochloride (Goe 4704 hydrochloride) is an antiarrhythmic agent. Asocainol hydrochloride reduces the maximum rate of action potential rise and action potential amplitude. Asocainol hydrochloride is applicable for the research of arrhythmias .
|
-
- HY-121675A
-
|
BOL-148 D-Tartrate; Bromolysergide D-Tartrate
|
5-HT Receptor
G protein-coupled Bile Acid Receptor 1
|
Neurological Disease
|
|
2-Bromo-LSD D-Tartrate (BOL-148 D-Tartrate) is a blood-brain barrier-permeable 5-HT2A partial agonist and competitive partial antagonist. 2-Bromo-LSD D-Tartrate acts as both a potent partial agonist (with an EC50 of 0.81 nM for Gq dissociation) and a potent partial antagonist (with a KB of 0.18 nM for Gq dissociation) at the 5-HT2A receptor. 2-Bromo-LSD D-Tartrate exhibits partial agonist activity at multiple aminergic GPCRs, including 5-HT2A. 2-Bromo-LSD D-Tartrate lacks 5-HT2B agonist activity. 2-Bromo-LSD D-Tartrate induces dendritogenesis and spinogenesis. 2-Bromo-LSD D-Tartrate reverses the behavioral effects of chronic stress and increases active coping behaviors in mice .
|
-
- HY-133240
-
|
|
DNA Alkylator/Crosslinker
Calcium Channel
Potassium Channel
Sodium Channel
|
Infection
|
|
trans-AzoTAB is a photoresponsive potassium/sodium/calcium channel modulator and DNA-binding agent. trans-AzoTAB undergoes trans-cis isomerization driven by light, with variable polarity and DNA affinity. trans-AzoTAB also enhances voltage-gated potassium currents and inhibits sodium and calcium currents in cardiomyocytes, thereby reducing spontaneous electrical activity and excitation conduction velocity. In addition, trans-AzoTAB induces compaction and frozen conformation of λ-phage DNA, and non-sequence-dependently inhibits transcription and translation processes in the dark; its activity can be reversed and restored by visible light after activation with ultraviolet irradiation. trans-AzoTAB can serve as a probe for two-photon optical regulation of myocardial excitability, and is used to construct photoresponsive interfacial polymer structures .
|
-
- HY-124940
-
|
|
Calcium Channel
Potassium Channel
|
Cardiovascular Disease
|
|
CPU-228 is a complex class III antiarrhythmic agent. CPU-228 concentration-dependently blocks the activities of the rapid component 50 of the delayed rectifier potassium channel (IKr) and the L-type calcium channel (ICa,L), with an IC50 value of 0.909 μM for ICa,L current. CPU-228 produces negative inotropic effects and induces mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atria. CPU-228 reduces the incidence of torsades de pointes (TDP) in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats. CPU-228 can be used in studies related to torsades de pointes .
|
-
- HY-P5152
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-103311
-
|
Ammoniated ruthenium oxychloride
|
Fluorescent Dye
|
|
Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker .
|
-
- HY-D2481
-
|
APG-2 (TMA)
|
Fluorescent Dye
|
|
Asante potassium green-2 (APG-2) TMA is a cell-impermeable K + (potassium ion) fluorescent indicator that produces a fluorescent response to changes in extracellular potassium ion concentration. Its excitation/emission maxima are 525/545 nm , respectively.
|
-
- HY-D2482
-
|
APG-1 AM
|
Fluorescent Dye
|
|
Asante potassium green-1 AM (APG-1 AM) is a cell-permeable K +-sensitive fluorescent indicator and potassium ion indicator that exhibits minimal interference from Na + and pH at physiologically relevant intracellular levels. Asante potassium green-1 AM enables non-invasive monitoring and quantitative analysis of intracellular potassium ion concentration (ᵢ) . Its excitation/emission maxima are 525/545 nm, respectively.
|
-
- HY-D1442
-
|
|
Fluorescent Dye
|
|
SBFI (tetraammonium), the tetraammonium salt of SBFI, is a cell-impermeant sodium fluorescence indicator. SBFI (tetraammonium) is sodium-sensitive dye. The excitation wavelength is set 333 nm, and the emission wavelength is 539 nm for SBFI .
|
-
- HY-172754
-
|
|
Fluorescent Dye
|
|
ICAAc is a solvatochromic fluorophore with reduced basicity. ICAAc demonstrates significant solvatochromic behavior across solvents of varying polarity, with a large dipole moment difference and low quantum yield in water, making it a tunable solvatochromic fluorophore. ICAAc enables pH sensing via UV-vis/fluorescence detection and in microenvironments including sodium lauryl sulfate micelle Stern layers. ICAAc acts as a supravital cell stain for epifluorescence imaging of live cancer cells .
|
| Cat. No. |
Product Name |
Type |
-
- HY-B1610N
-
|
|
Biochemical Assay Reagents
|
|
Sodium Citrate Buffer, 0.1M, pH 4.0 is an acidic, aqueous buffer solution. Sodium Citrate Buffer, 0.1M, pH 4.0 resists pH fluctuations, chelates metal ions, and regulates the redox potential of the system. Sodium Citrate Buffer, 0.1M, pH 4.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .
|
-
- HY-Y1325H
-
|
|
Biochemical Assay Reagents
|
|
Sodium acetate trihydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Sodium acetate trihydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Sodium acetate trihydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Sodium acetate trihydrate regulates energy metabolism. Sodium acetate trihydrate has anticancer activity against gastric cancer. Sodium acetate trihydrate induces writhing reaction and ulcerative colitis. Sodium acetate trihydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .
|
-
- HY-B2243B
-
|
sodium phosphate monobasic for molecular biology; Monosodium dihydrogen orthophosphate for molecular biology; Monosodium phosphate for molecular biology
|
Biochemical Assay Reagents
|
|
Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
|
-
- HY-141582
-
|
N-Stearoyl phytosphingosine
|
Biochemical Assay Reagents
|
|
Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin .
|
-
- HY-B1610J
-
|
|
Biochemical Assay Reagents
|
|
Sodium Citrate Buffer, 0.5M, pH 5.0 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 5.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .
|
-
- HY-Y0308H
-
|
Disodium hydrogen phosphate, for molecular biology
|
Biochemical Assay Reagents
|
|
Sodium phosphate dibasic (Disodium hydrogen phosphate), for molecular biology, is a type of phosphate salt that can be used in molecular biology research to prepare stable buffers free of RNase/DNase/protease .
|
-
- HY-B1610M
-
|
|
Biochemical Assay Reagents
|
|
Sodium Citrate Buffer, 0.5M, pH 6.5 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 6.5 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .
|
-
- HY-160113
-
|
|
Biochemical Assay Reagents
|
|
Sodium phosphate buffer 0.02 M, pH 6.9 is a commonly used aqueous biological buffer that maintains a stable pH value. Sodium phosphate buffer 0.02 M, pH 6.9 is often used in enzyme activity assays, such as α-amylase assays. Sodium phosphate buffer 0.02 M, pH 6.9 is prepared by mixing disodium hydrogen phosphate (Na2HPO4) (HY-B2243) and sodium dihydrogen phosphate (NaH2PO4) (HY-Y0308) to a total concentration of 0.02 M .
|
-
- HY-B2243D
-
|
sodium phosphate monobasic, for cell culture; Monosodium dihydrogen orthophosphate, for cell culture; Monosodium phosphate, for cell culture
|
Biochemical Assay Reagents
|
|
Anhydrous sodium dihydrogen phosphate, for cell culture is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for cell culture can be used in cell culture .
|
-
- HY-W250727
-
|
6-(p-Tolylamino)naphthalene-2-sulfonate sodium
|
Biochemical Assay Reagents
|
|
TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .
|
-
- HY-B1610L
-
|
|
Biochemical Assay Reagents
|
|
Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .
|
-
- HY-W019885A
-
|
sodium triphosphate pentabasic, 98%
|
Biochemical Assay Reagents
|
|
Sodium tripolyphosphate (STPP), 98% is an inorganic, non-toxic polyphosphate crosslinker, inducer and enhancer. Sodium tripolyphosphate (STPP), 98% induces the formation of unique needle-like microcrystals in sodium alginate-chitosan composite films. Sodium tripolyphosphate (STPP), 98% enhances the DPPH free radical scavenging activity of sodium alginate-chitosan composite films .
|
-
- HY-W134328
-
|
Dextran blue (MW 2000000)
|
Biochemical Assay Reagents
|
|
Blue dextran (Dextran blue) (MW 2000000) is a high-molecular-weight long-chain polymer of D-glucose. Blue dextran (MW 2000000) serves as an important model macromolecular drug and molecular weight estimation marker, and can be used as a standard for gel permeation chromatography. The release of Blue dextran (MW 2000000) from alginate microspheres is regulated by preparation conditions; its release rate in a pH 6.8 environment is significantly faster than that in pH 1.2, and it exhibits release characteristics close to zero-order kinetics under this condition .
|
-
- HY-W096983
-
|
Dodecyltrimethylammonium chloride,for IPC,≥99%
|
Biochemical Assay Reagents
|
|
DTAC (Dodecyltrimethylammonium chloride), for IPC, ≥99% is a quaternary ammonium cationic surfactant. DTAC, for IPC, ≥99% can form micelles in aqueous media, which interact with and encapsulate Diclofenac sodium (HY-15037) molecules; the micellization process is entropy-driven at lower temperatures and enthalpy-driven at higher temperatures .
|
-
- HY-W034344
-
|
|
Biochemical Assay Reagents
|
|
Sodium methanesulfonate is a hygroscopic atmospheric aerosol, which typically forms from the reaction of methanesulfonic acid with sodium chloride or sea salt particles. Sodium methanesulfonate can serve as a substrate for oxidation reactions, undergoing heterogeneous oxidation by hydroxyl radicals at the air-aerosol interface, thereby initiating subsequent aerosol-phase chain reactions. Sodium methanesulfonate exhibits significant temperature-dependent deliquescence and efflorescence properties; particularly at lower temperatures relevant to the troposphere, its deliquescence and efflorescence relative humidity increase accordingly .
|
-
- HY-76562
-
|
|
Biochemical Assay Reagents
|
|
Methyl 6-bromopicolinate is a synthetic intermediate used in the preparation of γ-secretase inhibitor library scaffolds .
|
-
- HY-W014841
-
|
N-Benzoylglycine sodium, 98%
|
Biochemical Assay Reagents
|
|
Sodium hippurate, 98% is an orally active metabolite. Sodium hippurate, 98% can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Sodium hippurate, 98% decreases NRF2, MMP9 and leads to ROS accumulation. Sodium hippurate, 98% activates TGFβ/SMAD signaling. Sodium hippurate, 98% improves hyperuricemia and colitis. Sodium hippurate, 98% can also be used in cardiovascular disease research .
.
|
-
- HY-W133954
-
|
|
Biochemical Assay Reagents
|
|
Sodium metaborate tetrahydrate, 99% is a derivative of the borax compound. Sodium metaborate tetrahydrate, 99% can be used as a source of boron in the production of sodium borohydride (NaBH4) .
|
-
- HY-Y0344H
-
|
Halite (Pharmaceutical primary standard, USP)
|
Biochemical Assay Reagents
|
|
Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells .
|
-
- HY-B1610K
-
|
|
Biochemical Assay Reagents
|
|
Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. .
|
-
- HY-Y0332H
-
|
sodium phosphate monobasic dihydrate, for molecular biology
|
Biochemical Assay Reagents
|
|
Sodium dihydrogen phosphate dihydrate (Sodium phosphate monobasic dihydrate), for molecular biology is a phosphate compound and nucleating agent. At a content of 1.2%, Sodium dihydrogen phosphate dihydrate, for molecular biology eliminates the supercooling degree of sodium acetate trihydrate to 0°C while maintaining or slightly enhancing its latent heat storage capacity. Sodium dihydrogen phosphate dihydrate, for molecular biology can serve as a starting material for the synthesis of degradable sodium phosphate glasses, which are applied in craniomaxillofacial bone repair. Sodium dihydrogen phosphate dihydrate, for molecular biology is widely used in research on craniomaxillofacial bone repair and related fields .
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- HY-W008585
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- HY-W094708D
-
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Disodium hydrogen phosphate dihydrate, meets analytical specification of Ph. Eur. BP
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Biochemical Assay Reagents
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Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research .
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- HY-Y1325E
-
|
sodium acetate trihydrate (Pharmaceutical primary standard, USP)
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Biochemical Assay Reagents
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Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt that can be used for life science related research .
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- HY-W009022
-
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Biochemical Assay Reagents
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Diantipyrylmethane is a chromogenic reagent commonly used for the determination of the contents of metals such as Au (III), Ti (IV), Ir, Fe (III), molybdenum, neodymium, U (IV), iridium, platinum and rhenium via spectrophotometry and extraction photometry. Diantipyrylmethane can also form a fluorescent complex with Er (III) ions, which is applied to the determination of erbium .
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- HY-111157
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AHR11748; AN051; ADD94057
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Biochemical Assay Reagents
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Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .
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| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1604
-
ATX-II
1 Publications Verification
|
Sodium Channel
|
Cardiovascular Disease
Inflammation/Immunology
|
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ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .
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- HY-P1604A
-
|
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Sodium Channel
|
Cardiovascular Disease
Inflammation/Immunology
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ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .
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- HY-P1218B
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Sodium Channel
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Neurological Disease
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Phrixotoxin 3-NH2 TFA is a derivative of Phrixotoxin 3 TFA (HY-P1218A). Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .
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- HY-P1220A
-
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Sodium Channel
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Neurological Disease
|
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Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain .
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-
- HY-P5152
-
|
|
Sodium Channel
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Neurological Disease
|
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Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .
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-
- HY-P10236
-
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Caspase
|
Others
|
|
Ac-WEHD-pNA is a colorimetric substrate for caspase 1, 4, 5 and 14, which is utilized to measure the caspase activity .
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-
- HY-P5807
-
|
β-Mammal toxin Cn2
|
Sodium Channel
|
Neurological Disease
|
|
Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage
sensing domain of voltage gated sodium channels (Nav)
.
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-
- HY-P1218
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .
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-
- HY-P11363
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
(Des-Asp1,Ile8)-Angiotensin II is a peptide related to angiotensin II. (Des-Asp1,Ile8)-Angiotensin II can be used for studying the interaction between angiotensin II and its receptors .
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-
- HY-P1219
-
|
β-TRTX-Cj1α
|
Sodium Channel
|
Neurological Disease
|
|
Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype .
|
-
- HY-P1220
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain .
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-
- HY-P5772
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC50 of 0.26 μM .
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-
- HY-P5943
-
-
- HY-P5942
-
-
- HY-P5180
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively .
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-
- HY-P5773
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Jingzhaotoxin-34, a 35-residue polypeptide, is a neurotoxin. Jingzhaotoxin-34 inhibits tetrodotoxin-sensitive (TTX-S) sodium currents (IC50 of ~85 nM) while having no significant effects on tetrodotoxin-resistant (TTX-R) sodium currents on rat dorsal root ganglion neurons .
|
-
- HY-P5177
-
-
- HY-P5179
-
|
HWTX-I
|
Calcium Channel
Sodium Channel
|
Neurological Disease
|
|
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively .
|
-
- HY-P5770
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Jingzhaotoxin-V, a 29-residue polypeptide, is derived from the venom of the spider Chilobrachys jingzhao. Jingzhaotoxin-V inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 nM and 30.2 nM, respectively. Jingzhaotoxin-V also inhibits Kv4.2 potassium currents expressed in Xenpus Laevis oocytes (IC50 of 604.2 nM) .
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-
- HY-P5771
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .
|
-
- HY-P5868
-
|
|
Sodium Channel
|
Neurological Disease
|
|
mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC50 of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .
|
-
- HY-P5184
-
|
HNTX-IV
|
Sodium Channel
|
Neurological Disease
|
|
Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .
|
-
- HY-P3777
-
|
|
Potassium Channel
|
Neurological Disease
|
|
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .
|
-
- HY-P1218A
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .
|
-
- HY-P5164
-
|
|
Sodium Channel
|
Neurological Disease
|
|
GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 μM, 0.23 μM, 0.77 μM, 1.29 μM, 0.63 μM and 0.37 μM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively . GrTx1 can be used for neurological disease research .
|
| Cat. No. |
Product Name |
Target |
Research Area |
Image |
-
- HY-P990163
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis .
|
-
(5)
-
- HY-P992040
-
|
16G2
|
Interleukin Related
|
Others
|
|
HAIL-12 is anan anti-human Interleukin-12 (IL-12p70) monoclonal antibody. HAIL-12 inhibits IL-12-mediated proliferation of T cells from human peripheral blood mononuclear cells .
|
-
(5)
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-111095S3A
-
|
|
|
D-(-)-Lactic acid- 13C-2 (sodium) is a 13C-labeled D-(-)-Lactic acid (HY-111095). D-(-)-Lactic acid can be used for a variety of biochemical studies.
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-132609
-
|
|
|
siRNAs
siRNA drugs
|
|
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis .
|
-
- HY-108764
-
|
ISIS 301012
|
|
Antisense Oligonucleotides
|
|
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .
|
-
- HY-147080
-
|
ARC1905
|
|
Aptamers
|
|
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .
|
-
- HY-132608
-
|
ISIS-420915 sodium
|
|
Antisense Oligonucleotides
|
|
Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy .
|
-
- HY-B2243B
-
|
sodium phosphate monobasic for molecular biology; Monosodium dihydrogen orthophosphate for molecular biology; Monosodium phosphate for molecular biology
|
|
Others
|
|
Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
|
-
- HY-100973
-
|
ADP ribose
|
|
Nucleotide Analogs
Adenine Nucleotide
|
|
Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD +) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca 2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy .
|
-
- HY-132613
-
|
|
|
siRNAs
siRNA drugs
|
|
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .
|
-
- HY-145725
-
|
IONIS 598769 sodium; ISIS 598769 sodium
|
|
Antisense Oligonucleotides
|
|
Baliforsen (sodium) is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.
|
-
- HY-109561
-
|
EYE001; NX1838
|
|
Aptamers
|
|
Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, which is directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .
|
-
- HY-132607A
-
|
CEBPA-51 sodium
|
|
saRNAs
|
|
MTL-CEBPA (sodium) is the sodium form of MTL-CEBPA (HY-132607). MTL-CEBPA (sodium) is a small activating RNA targeting for upregulation of C/EBPα. MTL-CEBPA (sodium) has anti-inflammatory and anti-cancer activity .
|
-
- HY-148410C
-
|
STK-001 negative control
|
|
Antisense Oligonucleotides
|
|
Zorevunensen (STK-001) negative control is the negative control form of Zorevunensen (HY-148410). Zorevunensen is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav1.1 protein. Zorevunersen is used for the study of Dravet syndrome .
|
-
- HY-132606C
-
|
|
|
siRNAs
siRNA drugs
|
|
Scrambled Nedosiran sodium is a scrambled sequence of Nedosiran sodium (HY-132606A). Scrambled Nedosiran sodium has a random sequence of the amino acids that are the same as the active fragment Nedosiran sodium. Scrambled Nedosiran sodium is usually used as a negative control .
|
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