2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Suzetrigine

Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy.

For research use only. We do not sell to patients.

CAS No. : 2649467-58-1

Size Price Stock Quantity
Free Sample (0.1 - 0.2 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
250 mg In-stock
500 mg In-stock
1 g In-stock
5 g   Get quote  
10 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Suzetrigine Related Antibodies

Top Publications Citing Use of Products

    Suzetrigine purchased from MedChemExpress. Usage Cited in: J Gen Physiol. 2025 Jul 7;157(4):e202413719.  [Abstract]

    Test for reverse use dependence using an AP waveform recorded from a human DRG neuron at 37°C, delivered at 20 Hz. Same for application of 1 nM VX-548.

    Suzetrigine purchased from MedChemExpress. Usage Cited in: J Gen Physiol. 2025 Jul 7;157(4):e202413719.  [Abstract]

    Same for 1 nM VX-548 (red, n = 7). Solid line: Boltzmann function with midpoint +33 mV, slope factor 16.3 mV.

    Suzetrigine purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 April 15.

    Representative raw trace example showing an MDA patient DRG neuron with ectopic discharge at baseline that ceased action potential (AP) firing and became hyperpolarized after application of Suzetrigine (10 nM; 1 min), as indicated by the blue bar above the trace.

    Suzetrigine purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 April 15.

    Suzetrigine (10 nM; 10 ms). where the pre-drug AP waveform is shown in black and the post-drug AP waveform is shown in blue.

    Suzetrigine purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 April 15.

    Evoked excitability was produced by a ramp stimulus applying a 1-100 pA ramp over 1 s, increasing the ramp end point by 200 pA each sweep. During VX-548 (10 nM) perfusion, the number of action potentials fired in each sweep significantly reduced relative to bath perfusion alone in the same cell.

    View All Sodium Channel Isoform Specific Products:

    View All Isoforms
    Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy[1][2][3][4][5].

    In Vivo


    Pharmacokinetic parameters of Suzetrigine in monkey plasma after oral and intravenous administrations[3]

    Parameters AUC0-t (ng·h/mL) Cmax (ng/mL) Tmax (h) T1/2 (h) CL (mL/min/kg) Vd (L/kg) MRT0-t (h) F (%)
    Intravenous (1 mg/kg, n = 3) 2843.2 ± 350.2 - - 4.6 ± 0.2 5.8 ± 0.6 2.3 ± 0.4 5.7 ± 0.2 71
    Oral (2 mg/kg, n = 3) 4040.8 ± 212.5 533.3 ± 10.6 1 5.0 ± 0.9 7.2 ± 0.5 3.5 ± 0.6 7.6 ± 0.7

    Pharmacokinetic parameters of Suzetrigine rats after intravenous administration at a single dose of 1 mg/kg[4]
    Parameters AUC0-t (ng·h/mL) T1/2 (h) CL (mL/min/kg) Vss (L/kg) MRT0-t (h)
    Female (n = 3) 1505.8 ± 47.3 3.7 ± 0.4 12.5 ± 0.8 5.0 ± 1.0 6.4 ± 0.3
    Male (n = 3) 253.8 ± 6.3 1.9 ± 0.2 65.1 ± 1.7 7.2 ± 0.8 1.7 ± 0.2

    Pharmacokinetic parameters of Suzetrigine rats after oral administration at a single dose of 2 mg/kg[4]
    Parameters AUC0-t (ng·h/mL) T1/2 (h) Cmax (ng/mL) Tmax (h) F (%)
    Female (n = 3) 2905.2 ± 98.6 4.9 ± 0.5 369.6 ± 62.2 0.5-1 96
    Male (n = 3) 56.9 ± 18.5 2.5 ±0.2 31.7 ± 12.5 0.5-1 11

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    473.39

    Formula

    C21H20F5N3O4
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    NC(C1=CC(NC([C@H]2[C@H](C3=C(C(F)=C(C=C3)F)OC)[C@@H]([C@@](C)(O2)C(F)(F)F)C)=O)=CC=N1)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 116.67 mg/mL (246.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1124 mL 10.5621 mL 21.1242 mL
    5 mM 0.4225 mL 2.1124 mL 4.2248 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.98%

    SDS (393 KB)

    COA (253 KB) HNMR (289 KB) RP-HPLC (225 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1124 mL 10.5621 mL 21.1242 mL 52.8106 mL
    5 mM 0.4225 mL 2.1124 mL 4.2248 mL 10.5621 mL
    10 mM 0.2112 mL 1.0562 mL 2.1124 mL 5.2811 mL
    15 mM 0.1408 mL 0.7041 mL 1.4083 mL 3.5207 mL
    20 mM 0.1056 mL 0.5281 mL 1.0562 mL 2.6405 mL
    25 mM 0.0845 mL 0.4225 mL 0.8450 mL 2.1124 mL
    30 mM 0.0704 mL 0.3521 mL 0.7041 mL 1.7604 mL
    40 mM 0.0528 mL 0.2641 mL 0.5281 mL 1.3203 mL
    50 mM 0.0422 mL 0.2112 mL 0.4225 mL 1.0562 mL
    60 mM 0.0352 mL 0.1760 mL 0.3521 mL 0.8802 mL
    80 mM 0.0264 mL 0.1320 mL 0.2641 mL 0.6601 mL
    100 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5281 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Suzetrigine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Suzetrigine2649467-58-1VX-548VX548VX 548Sodium ChannelNa channelsNa+ channelsNaV1.8sodium channelblockerneurological diseaseInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Suzetrigine
    Cat. No.:
    HY-148800
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.