(R)-(+)-Bupivacaine hydrochloride
(R)-(+)-Bupivacaine hydrochloride is a voltage-gated sodium channel inhibitor. (R)-(+)-Bupivacaine hydrochloride can selectively block the voltage-gated sodium channels on nerve cell membranes, inhibit the influx of sodium ions, and thus prevent the generation and conduction of nerve impulses, exerting local anesthetic activity. (R)-(+)-Bupivacaine hydrochloride can be used in research of acute pains.
For research use only. We do not sell to patients.
- CAS No.: 27262-46-0
- Formula: C18H29ClN2O
- Molecular Weight:324.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
276 μM
Compound: Dextro-(R)-bupivacaine
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Inhibition of human ERG Y652A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique
Inhibition of human ERG Y652A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique
|
[PMID: 21624711] |
| HEK293 | IC50 |
758 μM
Compound: Dextro-(R)-bupivacaine
|
Inhibition of human ERG F656A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique
Inhibition of human ERG F656A mutant channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique
|
[PMID: 21624711] |
| HEK293 | IC50 |
84 μM
Compound: Dextro-(R)-bupivacaine
|
Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique
Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp technique
|
[PMID: 21624711] |
Chemical Information
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CAS No. 27262-46-0
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Molecular Weight 324.89
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Formula C18H29ClN2O
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SMILES
CC(C=CC=C1C)=C1NC([C@@H]2N(CCCC2)CCCC)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-(+)-Bupivacaine hydrochloride Related Classifications
HY-Z6848 Related Classifications
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