2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Zandatrigine

Zandatrigine  (Synonyms: NBI-921352; XEN901)

Cat. No.: HY-147423 Purity: 99.29%
COA Handling Instructions

Molarity Calculator

Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha (Scn8α) blocker.

For research use only. We do not sell to patients.

Zandatrigine Chemical Structure

Zandatrigine Chemical Structure

CAS No. : 2154406-04-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 396 In-stock
Solution
10 mM * 1 mL in DMSO USD 396 In-stock
Solid
5 mg USD 360 In-stock
10 mg USD 590 In-stock
25 mg USD 1180 In-stock
50 mg USD 1880 In-stock
100 mg USD 3000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Zandatrigine Related Antibodies

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Description

Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha (Scn8α) blocker[1].

IC50 & Target

Scn8α[1]
Clinical Trial
Molecular Weight

460.59

Formula

C22H25FN4O2S2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CN([C@@H]1CN(CC1)CC2=CC=CC=C2)C3=C(C=C(C(F)=C3)S(NC4=CSC=N4)(=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (271.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1711 mL 10.8556 mL 21.7113 mL
5 mM 0.4342 mL 2.1711 mL 4.3423 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.29%

COA (249 KB) HNMR (287 KB) LCMS (271 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1711 mL 10.8556 mL 21.7113 mL 54.2782 mL
5 mM 0.4342 mL 2.1711 mL 4.3423 mL 10.8556 mL
10 mM 0.2171 mL 1.0856 mL 2.1711 mL 5.4278 mL
15 mM 0.1447 mL 0.7237 mL 1.4474 mL 3.6185 mL
20 mM 0.1086 mL 0.5428 mL 1.0856 mL 2.7139 mL
25 mM 0.0868 mL 0.4342 mL 0.8685 mL 2.1711 mL
30 mM 0.0724 mL 0.3619 mL 0.7237 mL 1.8093 mL
40 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3570 mL
50 mM 0.0434 mL 0.2171 mL 0.4342 mL 1.0856 mL
60 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.9046 mL
80 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6785 mL
100 mM 0.0217 mL 0.1086 mL 0.2171 mL 0.5428 mL
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Zandatrigine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zandatrigine2154406-04-7NBI-921352 XEN901NBI921352NBI 921352XEN901XEN 901XEN-901Sodium ChannelNa channelsNa+ channelsScn8αsodium channel protein type 8 subunit alphaInhibitorinhibitorinhibit

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