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Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney.

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Cyclopenthiazide Chemical Structure

Cyclopenthiazide Chemical Structure

CAS No. : 742-20-1

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Cyclopenthiazide Related Antibodies

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Description

Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney[1].

In Vivo

Cyclopenthiazide (0.5 mg/kg; i.p.; daily, for 3 days; female Wistar rats) increases the excretion of p-aminohippurate (PAH) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats[1]
Dosage: 0.5 mg/kg
Administration: Intraperitoneal injection; daily, for 3 days
Result: Stimulated p-aminohippurate (PAH) excretion.
Molecular Weight

379.88

Formula

C13H18ClN3O4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=C(Cl)C=C(C2=C1)NC(CC3CCCC3)NS2(=O)=O)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (329.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6324 mL 13.1621 mL 26.3241 mL
5 mM 0.5265 mL 2.6324 mL 5.2648 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6324 mL 13.1621 mL 26.3241 mL 65.8103 mL
5 mM 0.5265 mL 2.6324 mL 5.2648 mL 13.1621 mL
10 mM 0.2632 mL 1.3162 mL 2.6324 mL 6.5810 mL
15 mM 0.1755 mL 0.8775 mL 1.7549 mL 4.3874 mL
20 mM 0.1316 mL 0.6581 mL 1.3162 mL 3.2905 mL
25 mM 0.1053 mL 0.5265 mL 1.0530 mL 2.6324 mL
30 mM 0.0877 mL 0.4387 mL 0.8775 mL 2.1937 mL
40 mM 0.0658 mL 0.3291 mL 0.6581 mL 1.6453 mL
50 mM 0.0526 mL 0.2632 mL 0.5265 mL 1.3162 mL
60 mM 0.0439 mL 0.2194 mL 0.4387 mL 1.0968 mL
80 mM 0.0329 mL 0.1645 mL 0.3291 mL 0.8226 mL
100 mM 0.0263 mL 0.1316 mL 0.2632 mL 0.6581 mL
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Cyclopenthiazide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclopenthiazide742-20-1Othersbenzothiadiazine diureticdiureticsodium chloridewaterpolycyclic aromatic hydrocarbonsInhibitorinhibitorinhibit

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