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Cat. No.: HY-183646

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Nav1.8-IN-23

Nav1.8-IN-23 is a Na_v1.8 voltage-gated sodium channel inhibitor with a pIC₅₀ of 6.1. Nav1.8-IN-23 can be used for the research of pain-related diseases.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₁F₆N₄O₇P
Molecular Weight:610.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nav1.8-IN-23 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Nav1.8-IN-23 is a Na_v1.8 voltage-gated sodium channel inhibitor with a pIC₅₀ of 6.1. Nav1.8-IN-23 can be used for the research of pain-related diseases^[1].

IC₅₀ & Target^[1]

Na_v1.8

6.1 (pIC₅₀)

All Sodium Channel Isoforms :

In Vitro

Nav1.8-IN-23 (Compound 4) inhibits the Na_v1.8 channel expressed in HEK293-Na_v1.8 cells, with a pIC₅₀ value of 6.1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 610.40
Formula C₂₃H₂₁F₆N₄O₇P
SMILES

CC1=CC(OC(F)(F)F)=CC=C1N2CN(C(C3CC(C(F)(F)F)=CN=C32)=O)C4=C(N(C(C=C4)=O)COP(O)(O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Song R, et al. Novel 1‑Phenyl-2,3-dihydroquinazolin-4(1H)-one Derivatives as Nav 1.8 Voltage-Gated Sodium Channels Inhibitors. ACS Med Chem Lett. 2026 Apr 22;17(5):1028-1030. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Nav1.8-IN-23

All Sodium Channel Isoforms