Novel 1‑Phenyl-2,3-dihydroquinazolin-4(1H)-one Derivatives as Nav 1.8 Voltage-Gated Sodium Channels Inhibitors

  • ACS Med Chem Lett. 2026 Apr 22;17(5):1028-1030. doi: 10.1021/acsmedchemlett.6c00189.
Ruihu Song  1 ,  Steven H Liang  1  2
Affiliations
  • 1. Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
  • 2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States.
PMID: 42157813 DOI: 10.1021/acsmedchemlett.6c00189
Abstract

This highlight outlines the development of novel substituted 1-phenyl-2,3-dihydroquinazolin-4-(1H)-one derivatives as potential inhibitor candidates for Nav 1.8 voltage-gated sodium channels (Nav 1.8), which is upregulated or activated to transmit nociceptive signaling in a range of pain-related disorders. The invention includes details on preparation methods, biological activity assays, and pharmaceutical compositions.

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