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Cat. No.: HY-172754

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ICAAc

ICAAc is a solvatochromic fluorophore with reduced basicity. ICAAc demonstrates significant solvatochromic behavior across solvents of varying polarity, with a large dipole moment difference and low quantum yield in water, making it a tunable solvatochromic fluorophore. ICAAc enables pH sensing via UV-vis/fluorescence detection and in microenvironments including sodium lauryl sulfate micelle Stern layers. ICAAc acts as a supravital cell stain for epifluorescence imaging of live cancer cells.

For research use only. We do not sell to patients.

Formula: C₁₄H₉N₃
Molecular Weight:219.24

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Please store the product under the recommended conditions in the Certificate of Analysis.

ICAAc Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Bioz

Biological Activity

Description

In Vitro

ICAAc serves as a stable and accurate physiological pH probe in aqueous buffer solutions, with a pK_a value of 7.05, enabling precise pH detection within the physiological range of pH 6-8^[1].
ICAAC (0.3 μg/mL; incubation for imaging) serves as a suitable in vitro live-cell stain for routine epifluorescence imaging of live HeLa cells, with a recommended working concentration of 0.3 μg/mL^[1].
As the polarity of the solvent increases, the emission wavelength of ICAAc increases accordingly. In water, dioxane and n-hexane, its excitation/emission maxima are 466/553 nm, 431/515 nm and 418/503 nm, respectively. The absorption maximum of ICAAc decreases with increasing pH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 219.24
Formula C₁₄H₉N₃
SMILES

NC1=CC2=C(C=C3C(C=C([N+]#[C-])C=C3)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nagy M, et al. Amino-isocyanoacridines: Novel, Tunable Solvatochromic Fluorophores as Physiological pH Probes. Sci Rep. 2019;9(1):8250. Published 2019 Jun 3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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