1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. QX-314 bromide

QX-314 bromide 

Cat. No.: HY-101350
Handling Instructions

QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.

For research use only. We do not sell to patients.

QX-314 bromide Chemical Structure

QX-314 bromide Chemical Structure

CAS No. : 24003-58-5

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Description

QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].

IC50 & Target

sodium channel[1]

In Vitro

QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro [1].
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[1].
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death [1].
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 10% of control amplitude [3].
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- [3].

In Vivo

QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin[2].

Animal Model: Male Sprague-Dawley rats (250-290 g)[2]
Dosage: 1.6 mg/kg
Administration: Intracutaneous injection
Result: Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
Molecular Weight

343.30

Formula

C₁₆H₂₇BrN₂O

CAS No.

24003-58-5

SMILES

O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

QX-314QX314QX 314Sodium ChannelNa channelsNa+ channelssodiumchannel,calciumchannelInhibitorinhibitorinhibit

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QX-314 bromide
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HY-101350
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