1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. QX-314 chloride

QX-314 chloride 

Cat. No.: HY-108505 Purity: 99.83%
COA Handling Instructions

QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.

For research use only. We do not sell to patients.

QX-314 chloride Chemical Structure

QX-314 chloride Chemical Structure

CAS No. : 5369-03-9

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
25 mg USD 60 In-stock
50 mg USD 100 In-stock
100 mg USD 160 In-stock
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of QX-314 chloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].

IC50 & Target

sodium channel[1]

In Vitro

QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2].
? QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2].
? QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Room temperature in continental US; may vary elsewhere.


4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (167.31 mM; Need ultrasonic)

DMSO : 14.29 mg/mL (47.82 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3462 mL 16.7308 mL 33.4616 mL
5 mM 0.6692 mL 3.3462 mL 6.6923 mL
10 mM 0.3346 mL 1.6731 mL 3.3462 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (334.62 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.14 mg/mL (3.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (2.78 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (2.78 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.83%

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QX-314 chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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