1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. QX-314 chloride

QX-314 chloride 

Cat. No.: HY-108505
Handling Instructions

QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.

For research use only. We do not sell to patients.

QX-314 chloride Chemical Structure

QX-314 chloride Chemical Structure

CAS No. : 5369-03-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 59 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].

IC50 & Target

sodium channel[1]

In Vitro

QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2].
QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2].
QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2].

Molecular Weight

298.85

Formula

C₁₆H₂₇ClN₂O

CAS No.

5369-03-9

SMILES

O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

QX-314QX314QX 314Sodium ChannelNa channelsNa+ channelssodiumchannelcalciumInhibitorinhibitorinhibit

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QX-314 chloride
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HY-108505
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