1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. QX-314 chloride

QX-314 chloride 

Cat. No.: HY-108505
Handling Instructions

QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.

For research use only. We do not sell to patients.

QX-314 chloride Chemical Structure

QX-314 chloride Chemical Structure

CAS No. : 5369-03-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 59 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of QX-314 chloride:

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Description

QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].

IC50 & Target

sodium channel[1]

In Vitro

QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2].
QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2].
QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2].

Molecular Weight

298.85

Formula

C₁₆H₂₇ClN₂O

CAS No.

5369-03-9

SMILES

O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (47.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3462 mL 16.7308 mL 33.4616 mL
5 mM 0.6692 mL 3.3462 mL 6.6923 mL
10 mM 0.3346 mL 1.6731 mL 3.3462 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (2.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (2.78 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (2.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

QX-314QX314QX 314Sodium ChannelNa channelsNa+ channelssodiumchannelcalciumInhibitorinhibitorinhibit

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Product name:
QX-314 chloride
Cat. No.:
HY-108505
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