1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF-05186462

PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain.

For research use only. We do not sell to patients.

PF-05186462 Chemical Structure

PF-05186462 Chemical Structure

CAS No. : 1235406-03-7

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Based on 1 publication(s) in Google Scholar

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Description

PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain[1].

IC50 & Target

IC50: 21 nM (human Nav1.7)[1]

In Vitro

PF-05186462 inhibits human Nav1.7 channels (IC50=21 nM) in HEK293 cells[1].
PF-05186462 exhibits a high plasma protein binding rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

531.89

Formula

C19H10ClF4N5O3S2

CAS No.
SMILES

O=S(C1=CC(Cl)=C(OC2=CC=C(C(F)(F)F)C=C2C3=CC=NN=C3)C=C1F)(NC4=NN=CS4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PF-05186462 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PF-05186462
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HY-122001
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