2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Recainam

Recainam (Wy-42362) is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam can be used for the research of arrhythmias.

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Recainam

Recainam Chemical Structure

CAS No. : 74738-24-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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  • Biological Activity

  • Purity & Documentation

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Description

Recainam (Wy-42362) is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam can be used for the research of arrhythmias[1][2][3][4].

In Vitro

Recainam (10-300 μM; ≥30 min) has no significant effect on key electrophysiologic variables of isolated rabbit sinoatrial node preparations, aside from modestly shortening action potential duration[2].
Recainam (10-100 μM; ≥30 min) significantly reduces the maximal rate of rise of phase 0 (V̇max) in isolated rabbit atrial muscle preparations without altering other key electrophysiologic variables[2].
Recainam (10-300 μM; ≥30 min) causes concentration-dependent reductions in the maximal rate of rise of phase 0 (V̇max) in isolated canine ventricular muscle preparations without altering action potential duration or effective refractory period[2].
Recainam (1-300 μM; ≥30 min) causes concentration-dependent reductions in the maximal rate of rise of phase 0 (V̇max), action potential amplitude, action potential duration, and effective refractory period in isolated canine Purkinje fiber preparations[2].
Recainam (10-60 μM; ≥30 min) shifts the membrane responsiveness curve in the hyperpolarizing direction in isolated canine Purkinje fiber preparations, with higher concentrations abolishing premature responses from depolarized membrane potentials[2].
Recainam (300 μM; ≥30 min) induces a frequency-dependent reduction in the maximal rate of rise of phase 0 (V̇max) in isolated canine Purkinje fiber, canine ventricular muscle, and rabbit atrial muscle preparations, and abolishes responses at frequencies >3 Hz in Purkinje fibers[2].
Recainam (100 μM; ≥10 min) depresses phase 4 depolarization and slows isoproterenol-induced automaticity in isolated canine Purkinje fiber preparations[2].
Recainam (300 μM; ≥30 min) does not affect slow channel-dependent potentials induced by high potassium and isoproterenol in isolated canine ventricular muscle and Purkinje fiber preparations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Recainam Related Antibodies
Parmacokinetics
Species Dose Route AUC0-∞ T1/2 MRT Vss Cmax Bioavailability
Mice[3] 54 mg/kg p.o. / / / / 6.4 μg/mL /
Mice[3] 120 mg/kg p.o. 26.9 μg·h/mL 1.2 h / / 23.5 μg/mL /
Mice[3] 208 mg/kg p.o. 64.3 μg·h/mL 1.0 h / / 48.7 μg/mL /
Mice[3] 100 mg/kg p.o. 16.6 μg·h/mL 0.8 h / / 13.5 μg/mL /
Rat[3] 20 mg/kg i.v. 4.1 μg·h/mL 0.6 h 0.6 h 3.2 L/kg / /
Rat[3] 100 mg/kg p.o. 10.5 μg·h/mL 3.1 h / / 1.3 μg/mL 51 %
Rat[3] 110 mg/kg p.o. 19.9 μg·h/mL 4.5 h / / 6.6 μg/mL /
Rat[3] 500 mg/kg p.o. 73.9 μg·h/mL 3.6 h / / 7.8 μg/mL /
Rabbit[3] 25 mg/kg i.v. 5.0 μg·h/mL 0.6 h 0.7 h 3.6 L/kg / /
Rabbit[3] 50 mg/kg p.o. / / / / 4.1 μg/mL /
Rabbit[3] 100 mg/kg p.o. 39.6 μg·h/mL 3.4 h / / 16.0 μg/mL /
Dog[3] 15 mg/kg i.v. 20.9 μg·h/mL 1.8 h 2.3 h 1.2 L/kg / /
Dog[3] 15 mg/kg p.o. 18.1 μg·h/mL 2.0 h / / 8.5 μg/mL 89 %
Rhesus monkey[3] 15 mg/kg i.v. 12.8 μg·h/mL 1.6 h 1.9 h 2.2 L/kg / /
Rhesus monkey[3] 15 mg/kg p.o. 12.0 μg·h/mL 1.9 h / / 3.3 μg/mL 97 %
In Vivo

Recainam (3.75-7.5 mg/kg loading; 0.0375-0.075 mg/kg per min maintenance; i.v.; loading dose over 20 min; maintenance infusion for remainder of experiment) elevates the energy required for ventricular defibrillation in a dose-dependent manner, with low and high doses increasing E50 by 42% and 92%, respectively, while prolonging QRS duration without altering ventricular effective refractory period[1].
Recainam (p.o.; i.v.) exhibits anti-arrhythmic activity in dogs with experimentally induced cardiac arrhythmias[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mongrel dogs (male, 14-23 kg, anesthetized with sodium pentobarbital)[1]
Dosage: 3.75 mg/kg (loading) + 0.0375 mg/kg per min (maintenance); 7.5 mg/kg (loading) + 0.075 mg/kg per min (maintenance)
Administration: i.v.; loading dose over 20 min; maintenance infusion for remainder of experiment
Result: Increased sinus QRS duration by 11% and paced QRS duration by 14% at low dose.
Produced no significant change in ventricular effective refractory period or sinus cycle length at low dose.
Increased E50 by 42% at low dose.
Increased sinus QRS duration by 27% and paced QRS duration by 23% at high dose.
Produced no significant change in ventricular effective refractory period or sinus cycle length at high dose.
Increased E50 by 92% at high dose.
Caused changes in E50 that were significantly different from the saline group and between low and high dose groups.
Showed no statistically significant difference in percent change of sinus QRS duration between low and high dose groups.
Molecular Weight

263.38

Formula

C15H25N3O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)NCCCNC(NC1=C(C=CC=C1C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (189.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7968 mL 18.9840 mL 37.9680 mL
5 mM 0.7594 mL 3.7968 mL 7.5936 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7968 mL 18.9840 mL 37.9680 mL 94.9199 mL
5 mM 0.7594 mL 3.7968 mL 7.5936 mL 18.9840 mL
10 mM 0.3797 mL 1.8984 mL 3.7968 mL 9.4920 mL
15 mM 0.2531 mL 1.2656 mL 2.5312 mL 6.3280 mL
20 mM 0.1898 mL 0.9492 mL 1.8984 mL 4.7460 mL
25 mM 0.1519 mL 0.7594 mL 1.5187 mL 3.7968 mL
30 mM 0.1266 mL 0.6328 mL 1.2656 mL 3.1640 mL
40 mM 0.0949 mL 0.4746 mL 0.9492 mL 2.3730 mL
50 mM 0.0759 mL 0.3797 mL 0.7594 mL 1.8984 mL
60 mM 0.0633 mL 0.3164 mL 0.6328 mL 1.5820 mL
80 mM 0.0475 mL 0.2373 mL 0.4746 mL 1.1865 mL
100 mM 0.0380 mL 0.1898 mL 0.3797 mL 0.9492 mL
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Recainam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Recainam74738-24-2Wy-42362Wy42362Wy 42362Sodium ChannelNa channelsNa+ channelsventricular musclecardiac arrhythmiasPurkinje fiberspremature ventricular complexessodium channelventricular arrhythmiassinoatrial nodeatrial muscleventricular ectopic beatscanineInhibitorinhibitorinhibit

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