DL-Polylactic acid 

DL-Poly (lactic acid) is a biodegradable poly (α-hydroxy acid) matrix and a coating material for controlled drug release. DL-Poly (lactic acid) is classified as a drug release retardant, which degrades into natural lactic acid monomers, an intermediate product of carbohydrate metabolism, enabling complete drug delivery that lasts for several weeks. Its drug release rate is affected by the pH of the surrounding environment^[1][2].

DL-poly (lactic acid) matrix tablets achieve complete release of Diclofenac Sodium (HY-15037) within 40 days (with faster release under pH 7.4 conditions), and partial to near-complete release of Propranolol (HY-B0573B) within 60 days (with accelerated release after 35 days under pH 5.4 conditions) via a mechanism combining diffusion and polymer degradation^[1].
DL-Poly (lactic acid)-coated microcapsules can retard the release of Cyclazocine^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

102.13

C₅H₁₀O₂

26023-30-3

COC(C)C(C)=O.[n]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mamouzelos NJ, et al. Release of propranolol and diclofenac from low Mw DL-poly(lactic acid). J Biomater Appl. 2002;16(3):177-190.  [Content Brief]

  [2]. Mason N, et al. In vivo and in vitro evaluation of a microencapsulated narcotic antagonist. J Pharm Sci. 1976;65(6):847-850.  [Content Brief]