2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. XPC-5462

XPC-5462 is a NaV1.6 and NaV1.2 inhibitor with the IC50s of 10.9 nM and 10.3 nM, respectively. XPC-5462 suppresses epileptiform activity in an ex vivo brain slice seizure model.

For research use only. We do not sell to patients.

XPC-5462 Chemical Structure

XPC-5462 Chemical Structure

CAS No. : 2230145-14-7

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Description

XPC-5462 is a NaV1.6 and NaV1.2 inhibitor with the IC50s of 10.9 nM and 10.3 nM, respectively. XPC-5462 suppresses epileptiform activity in an ex vivo brain slice seizure model[1].

IC50 & Target

Nav1.2

10.3 nM (IC50)

Nav1.6

10.9 nM (IC50)

Molecular Weight

486.51

Formula

C20H18F4N4O2S2
CAS No.
SMILES

O=S(NC1=CSC=N1)(C2=C(C=C(C=C2F)NCC3=C(C(F)=CC=C3F)CN4CCC4)F)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XPC-5462 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XPC-54622230145-14-7XPC5462XPC 5462Sodium ChannelNa channelsNa+ channelsepilepsysodium channelInhibitorinhibitorinhibit

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HY-157786
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