1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Bepridil hydrochloride hydrate

Bepridil hydrochloride hydrate (Synonyms: (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate)

Cat. No.: HY-16952A Purity: 99.70%
Handling Instructions

Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders.

For research use only. We do not sell to patients.

Bepridil hydrochloride hydrate Chemical Structure

Bepridil hydrochloride hydrate Chemical Structure

CAS No. : 74764-40-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 220 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5].

IC50 & Target[1]

Ca2+

 

In Vitro

Bepridil hydrochloride hydrate blockades of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary artery[2].
Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC50s of 0.5 μM and 30 μM, respectively in cultured ventricular cells[4].
Bepridil hydrochloride hydrate decreases IKs under blockade of IKr with E4031 (5 μM), in a concentration-dependent manner[5].

In Vivo

Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration[6].

Molecular Weight

421.02

Formula

C₂₄H₃₇ClN₂O₂

CAS No.

74764-40-2

SMILES

CC(C)COCC(N1CCCC1)CN(C2=CC=CC=C2)CC3=CC=CC=C3.[H]Cl.[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (593.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3752 mL 11.8759 mL 23.7518 mL
5 mM 0.4750 mL 2.3752 mL 4.7504 mL
10 mM 0.2375 mL 1.1876 mL 2.3752 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Bepridil hydrochloride(±)-Bepridil hydrochlorideOrg 5730 hydrochlorideCalcium ChannelCa2+ channelsCa channelscalciumsodiumpotassiumchannelantianginalantiarrhythmiccardiovasculardisordersInhibitorinhibitorinhibit

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Product name:
Bepridil hydrochloride hydrate
Cat. No.:
HY-16952A
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