2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Bepridil hydrochloride hydrate

Bepridil hydrochloride hydrate  (Synonyms: (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate)

Cat. No.: HY-16952A Purity: 99.70%
COA Handling Instructions

Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders.

For research use only. We do not sell to patients.

Bepridil hydrochloride hydrate Chemical Structure

Bepridil hydrochloride hydrate Chemical Structure

CAS No. : 74764-40-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 66 In-stock
Solid
1 mg USD 28 In-stock
5 mg USD 60 In-stock
10 mg USD 100 In-stock
25 mg USD 220 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 3 publication(s) in Google Scholar

Other Forms of Bepridil hydrochloride hydrate:

Bepridil hydrochloride hydrate Related Antibodies

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Description

Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5].

In Vitro

Bepridil hydrochloride hydrate blockades of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary artery[2].
Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC50s of 0.5 μM and 30 μM, respectively in cultured ventricular cells[4].
Bepridil hydrochloride hydrate decreases IKs under blockade of IKr with E4031 (5 μM), in a concentration-dependent manner[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bepridil hydrochloride hydrate Related Antibodies
In Vivo

Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

421.02

Appearance

Solid

Formula

C24H37ClN2O2
CAS No.
SMILES

CC(C)COCC(N1CCCC1)CN(C2=CC=CC=C2)CC3=CC=CC=C3.[H]Cl.[H]O[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (296.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3752 mL 11.8759 mL 23.7518 mL
5 mM 0.4750 mL 2.3752 mL 4.7504 mL
10 mM 0.2375 mL 1.1876 mL 2.3752 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.73%

COA (252 KB) HNMR (283 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References
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Bepridil hydrochloride hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Bepridil hydrochloride74764-40-2(±)-Bepridil hydrochlorideOrg 5730 hydrochlorideCalcium ChannelCa2+ channelsCa channelscalciumsodiumpotassiumchannelantianginalantiarrhythmiccardiovasculardisordersInhibitorinhibitorinhibit

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