1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Ibutilide

Ibutilide (Synonyms: U70226E free base)

Cat. No.: HY-B0387A
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Ibutilide (U70226E free base), an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells.

For research use only. We do not sell to patients.

Ibutilide Chemical Structure

Ibutilide Chemical Structure

CAS No. : 122647-31-8

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Description

Ibutilide (U70226E free base), an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells[1].

In Vitro

Ibutilide is a potent IKr blocker with EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells[1].
Ibutilide blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC50: 22.5±0.9 vs 27.4±2.5 nM). However, cells expressing MDR1*7 show a marked resistance to Ibutilide (IC50: 105.3±1.42 nM vs 27.4±2.5 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ibutilide prolongs cardiac repolarization in vitro and in vivo[1].
Ibutilide infusions (administered cumulatively in three doses, 0.01, 0.02 and 0.05 mg/kg i.v., each as a 10-min infusion) results in both polymorphic and monomorphic non-sustained ventricular tachycardia[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifteen adult mongrel dogs of either sex[1]
Dosage: 0.01, 0.02 and 0.05 mg/kg
Administration: Infusion
Result: The action potential duration at 90% (APD90) prolongation with Ibutilide (0.01 mg/kg) was significantly greater in congestive heart failure (CHF) vs. controls. 
An increased dispersion of left–right ventricular APD90 was observed in CHF at 0.01 mg/kg, but not in controls. 
Molecular Weight

384.58

Formula

C20H36N2O3S

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Storage

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Ibutilide
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