KC 12291 hydrochloride
KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 181936-98-1
- Formula: C22H28ClN3O3S
- Molecular Weight:449.99
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
KC 12291 hydrochloride (1 μM) reduces the peak of Na+ current approximately 60 % in rat ventricular cardiomyocytes[1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
KC 12291 hydrochloride (60 mg/kg for p.o) has plasma Cmax values of 1.3 and 1.4 μg/mL for female and male rats, respectively, and the value of plasma Tmax is close to 2 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Anesthetized rabbit model[1]
-
Dosage:0.16, 0.63 mg/kg
-
Administration:Oral administration (p.o.); Once
-
Result:Significantly attenuated the coronary occlusion produced marked ST segment elevation about 68 % at 0.63 mg/kg.
Chemical Information
-
CAS No. 181936-98-1
-
Molecular Weight 449.99
-
Formula C22H28ClN3O3S
-
SMILES
[H]Cl.CN(CCCOC1=NSC(C2=CC=CC=C2)=N1)CCC3=CC=C(OC)C(OC)=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz