2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. KC 12291 hydrochloride

KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo.

For research use only. We do not sell to patients.

KC 12291 hydrochloride Chemical Structure

KC 12291 hydrochloride Chemical Structure

CAS No. : 181936-98-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

KC 12291 hydrochloride Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].

In Vitro

KC 12291 hydrochloride (1 μM) reduces the peak of Na+ current approximately 60 % in rat ventricular cardiomyocytes[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KC 12291 hydrochloride Related Antibodies
In Vivo

KC 12291 hydrochloride (0.63 mg/kg for p.o; once) exerts significant antiischemic activity in anesthetized rabbit model[1].
KC 12291 hydrochloride (60 mg/kg for p.o) has plasma Cmax values of 1.3 and 1.4 μg/mL for female and male rats, respectively, and the value of plasma Tmax is close to 2 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized rabbit model[1]
Dosage: 0.16, 0.63 mg/kg
Administration: Oral administration (p.o.); Once
Result: Significantly attenuated the coronary occlusion produced marked ST segment elevation about 68 % at 0.63 mg/kg.
Molecular Weight

449.99

Formula

C22H28ClN3O3S
CAS No.
SMILES

[H]Cl.CN(CCCOC1=NSC(C2=CC=CC=C2)=N1)CCC3=CC=C(OC)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

KC 12291 hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KC 12291181936-98-1KC12291KC-12291Sodium ChannelNa channelsNa+ channelsAntiischemicCardioprotectivevoltage-gated sodium channelVGSCAnesthetized rabbit model.Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
KC 12291 hydrochloride
Cat. No.:
HY-108502
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.