Asante potassium green-2 TMA  (Synonyms: APG-2 TMA)

Asante potassium green-2 TMA (APG-2 (TMA)) is a cell-impermeable K⁺ fluorescent indicator that produces a fluorescent response to changes in extracellular potassium ion concentration (Ex/Em = 525/545 nm)^[1].

Asante potassium green-2 TMA (APG-2 (TMA)) loaded shielded mesoporous silica nanoparticles (0.5 mg/mL; 24 h) enables high-selectivity, high-sensitivity, reversible and fast kinetic-responsive fluorescent detection of potassium ions^[1].
Asante potassium green-2 TMA (APG-2 (TMA)) loaded shielded mesoporous silica nanoparticles (20 μg/mL; 20 min) specifically detects extracellular K⁺ efflux in primary cultured rat hippocampal neurons during pharmacologically induced epileptiform activity, with stronger fluorescent signals observed in axonal compartments relative to soma regions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1131.23

C₅₈H₈₅Cl₂N₅O₁₃

1369302-21-5

Solid

Brown to reddish brown

O=C([O-])CCC1=CC2=C(C3=C(OC2=C(Cl)C1=O)C(Cl)=C([O-])C(CCC([O-])=O)=C3)C4=CC(OC)=C(C=C4)N5CCOCCOCCN(C6=CC=C(C=C6OC)C)CCOCCOCC5.C[N+](C)(C)C.C[N+](C)(C)C.C[N+](C)(C)C

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Liu J, et al. A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain. Nat Nanotechnol. 2020;15(4):321-330.  [Content Brief]