Hardwickiic acid
Based on 1 publication(s) in Google Scholar
Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases.
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- Reinheit : 99.91%
- CAS. Nr.: 1782-65-6
- Formel: C20H28O3
- Molecular Weight:316.43
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Hardwickiic acid
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Biologische Aktivität
Beschreibung
In Vitro
Hardwickiic acid (0-100 nM; 90 s) promotes K+-evoked [3H]noradrenaline overflow in mouse hippocampal synaptosomes[1].
Hardwickiic acid (5 ppm; 24 h) causes 62% mortality in adult female Aphis craccivora aphids[2].
Hardwickiic acid (20 μM) inhibits tetrodotoxin-sensitive voltage-gated sodium channels in rat dorsal root ganglion neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats (225-250 g) treated HIV-1 gp120 or Paclitaxel (HY-B0015)[3]
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Dosage:2 μg/5 μL
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Administration:Intrathecal injection; single dose
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Result:Significantly reversed mechanical allodynia 1-2 h post-injection, with the effect lasting for 2-3 additional hours in HIV-1 gp120-induced sensory neuropathy model.
Significantly relieved mechanical allodynia 0.5 h post-injection, with the effect lasting for 2-3 hours in paclitaxel-induced peripheral neuropathy model.
Chemical Information
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CAS. Nr. 1782-65-6
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Appearance Solid
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Molecular Weight 316.43
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Formel C20H28O3
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Color White to off-white
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SMILES
C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3
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Synonyms
(-)-Hardwickiic acid; (-)-Hardwikiic acid
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Structure Classification
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2023 Jun 3;14(1):3224. PMID: 37270609
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 Mar;62(4):354-9. [Content Brief]
[2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575. [Content Brief]
[3]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Hardwickiic acid Related Classifications
HY-N3990 Related Classifications
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