Hardwickiic acid
Based on 1 publication(s) in Google Scholar
Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 1782-65-6
- Formula: C20H28O3
- Molecular Weight:316.43
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hardwickiic acid
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Biological Activity
Hardwickiic acid (0-100 nM; 90 s) promotes K+-evoked [3H]noradrenaline overflow in mouse hippocampal synaptosomes[1].
Hardwickiic acid (5 ppm; 24 h) causes 62% mortality in adult female Aphis craccivora aphids[2].
Hardwickiic acid (20 μM) inhibits tetrodotoxin-sensitive voltage-gated sodium channels in rat dorsal root ganglion neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Sprague-Dawley rats (225-250 g) treated HIV-1 gp120 or Paclitaxel (HY-B0015)[3]
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Dosage:2 μg/5 μL
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Administration:Intrathecal injection; single dose
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Result:Significantly reversed mechanical allodynia 1-2 h post-injection, with the effect lasting for 2-3 additional hours in HIV-1 gp120-induced sensory neuropathy model.
Significantly relieved mechanical allodynia 0.5 h post-injection, with the effect lasting for 2-3 hours in paclitaxel-induced peripheral neuropathy model.
Chemical Information
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CAS No. 1782-65-6
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Appearance Solid
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Molecular Weight 316.43
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Formula C20H28O3
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Color White to off-white
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SMILES
C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3
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Synonyms
(-)-Hardwickiic acid; (-)-Hardwikiic acid
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2023 Jun 3;14(1):3224. PMID: 37270609
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 Mar;62(4):354-9. [Content Brief]
[2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575. [Content Brief]
[3]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hardwickiic acid Related Classifications
HY-N3990 Related Classifications
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