GrTx1
GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel, with IC50s of 0.63 μM, 0.23 μM, 0.77 μM, 1.29 μM, 0.63 μM and 0.37 μM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively. GrTx1 can be used for neurological disease research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C159H243N45O41S8
- 분자량:3697.43
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
GrTx1 (0-100 μΜ, 3 min) blocks Na+ currents of neuroblastoma F-11 cells with an IC50 of 2.8 μM[1]. GrTx1 (10 μΜ, 3 min) blocks about 85% Na+ currents of neuroblastoma F-11 cells with no effects on common K+ channels, such as Kv1.1 and 1.4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
분자량 3697.43
-
화학식 C159H243N45O41S8
-
Sequence
Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Lys-Arg-Lys-Cys-Cys-Glu-Asp-Met-Val-Cys-Gln-Leu-Trp-Cys-Lys-Lys-Arg-Leu (Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25)
-
Sequence Shortening
YCQKWMWTCDSKRKCCEDMVCQLWCKKRL (Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25)
-
Initial Source
Grammostola rosea
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Clement H,et.al. Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels. Toxicon. 2007 Jul;50(1):65-74. [Content Brief]
[2]. Redaelli E, et.al. Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. J Biol Chem. 2010 Feb 5;285(6):4130-4142. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz