1. Protein Tyrosine Kinase/RTK
  2. VEGFR
  3. Pegaptanib sodium

Pegaptanib sodium  (Synonyms: EYE001; NX1838)

Cat. No.: HY-109561 Purity: 98.09%
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Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

For research use only. We do not sell to patients.

Poly(oxy-1,2-ethanediyl), α-hydro-ω-methoxy-, 5′-ester with RNA ((2′-deoxy-2′-fluoro)C-Gm-Gm-A-A-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-Am-Gm-(2′-deoxy-2′-fluoro)U-Gm-Am-Am-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)U-Am-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)C-Gm-(3′→3′)-dT) 5′-[5-[[2,6-bis(carboxyamino)-1-oxohexyl]amino]pentyl hydrogen phosphate] (2:1), sodium salt

Pegaptanib sodium Chemical Structure

CAS No. : 222716-86-1

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5 mg USD 562 In-stock
10 mg USD 882 In-stock
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Description

Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) [1].

In Vitro

Pegaptanib also inhibits VEGF165-mediated phosphorylation of VEGFR2 and phospholipase Cγ and inhibited VEGF165-induced calcium mobilization in human umbilical vein endothelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

50000 (Approximately)

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2?-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'?3')-dT), 5'-ester with ?,?'-[4,12-dioxo-6-[[[5-(phosphoonoxy)pentyl]amino]carbonyl]-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl]bis[?-methoxypoly(oxy-1,2-ethanediyl)], sodium salt

SMILES

[Pegaptanib (sodium)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pegaptanib sodium
Cat. No.:
HY-109561
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