Valerate sodium

Cat. No.: HY-W007087 Purity: 98%: Data Sheet
COA

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Handling Instructions
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Valerate sodium is the sodium salt of valeric acid, a short-chain fatty acid, and exhibits oral activity. Valerate sodium reduces binge ethanol intake and decreases blood ethanol concentration in mice, while also exerting anxiolytic effects. Valerate sodium increases GABA levels, regulates epigenetics and alters gut microbiome function. Valerate sodium can be used in research related to excessive alcohol consumption.

For research use only. We do not sell to patients.

Valerate sodium Chemical Structure

CAS No. : 6106-41-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
250 g	In-stock	Estimated Time of Arrival: December 31
500 g	In-stock	Estimated Time of Arrival: December 31
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Description

In Vivo

Sodium valerate (200 mM; p.o.; daily; 10 consecutive days) supplementation produces a 40% reduction in binge ethanol consumption and a 53% reduction in blood ethanol concentration in male C57BL/6J mice, alongside anxiolytic effects, increased GABA levels, epigenetic modulation, and altered gut microbiome function^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J (male, 6-8 weeks old)^[1]
Dosage:	200 mM
Administration:	p.o.; daily; 10 consecutive days
Result:	Reduced ethanol consumption by 40%. Lowered blood ethanol concentration by 53%. Increased percentage of time spent in the center of the open field and number of center entries, with no change in total distance traveled. Elevated GABA levels in stool and amygdala. Increased H4 histone acetylation in the amygdala. Induced significant changes in amygdala gene expression, including upregulation of Kcna10, Pln, and Gpr56, and downregulation of Ptgs2, Mapks, and Gpr158; associated pathways included glutamate degradation, L-DOPA degradation, and anti-inflammatory effects. Altered gut microbiome composition, with increased abundance of genera Ileibacterium and Dubosiella; reduced gut-brain module activity for GABA degradation and 7 other neuroactive compound pathways. No significant effects on body weight, food intake, or fluid intake compared to controls.

Clinical Trial

Molecular Weight

124.11

Formula

C₅H₉NaO₂

CAS No.

6106-41-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 200 mg/mL (1611.47 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.0574 mL	40.2868 mL	80.5737 mL
5 mM	1.6115 mL	8.0574 mL	16.1147 mL
10 mM	0.8057 mL	4.0287 mL	8.0574 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98%

Select Batch:

Data Sheet (269 KB) SDS (394 KB)

COA (243 KB) HNMR (153 KB)

Handling Instructions (2659 KB)

References

[1]. Bokoliya SC, et al. Short-chain fatty acid valerate reduces voluntary alcohol intake in male mice. Microbiome. 2024;12(1):108. Published 2024 Jun 17. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	8.0574 mL	40.2868 mL	80.5737 mL	201.4342 mL
	5 mM	1.6115 mL	8.0574 mL	16.1147 mL	40.2868 mL
	10 mM	0.8057 mL	4.0287 mL	8.0574 mL	20.1434 mL
	15 mM	0.5372 mL	2.6858 mL	5.3716 mL	13.4289 mL
	20 mM	0.4029 mL	2.0143 mL	4.0287 mL	10.0717 mL
	25 mM	0.3223 mL	1.6115 mL	3.2229 mL	8.0574 mL
	30 mM	0.2686 mL	1.3429 mL	2.6858 mL	6.7145 mL
	40 mM	0.2014 mL	1.0072 mL	2.0143 mL	5.0359 mL
	50 mM	0.1611 mL	0.8057 mL	1.6115 mL	4.0287 mL
	60 mM	0.1343 mL	0.6714 mL	1.3429 mL	3.3572 mL
	80 mM	0.1007 mL	0.5036 mL	1.0072 mL	2.5179 mL
	100 mM	0.0806 mL	0.4029 mL	0.8057 mL	2.0143 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Valerate sodium Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valerate6106-41-8GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorshort-chain fatty acidsodiumexcessive alcohol consumptionanxiolyticC57BL/6J miceInhibitorinhibitorinhibit

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Valerate sodium

Valerate sodium Related Antibodies

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