1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Brevetoxin B

Brevetoxin B (Synonyms: Brevetoxin-2; PbTx-2)

Cat. No.: HY-12546
Handling Instructions

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

For research use only. We do not sell to patients.

Brevetoxin B Chemical Structure

Brevetoxin B Chemical Structure

CAS No. : 79580-28-2

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Description

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

Molecular Weight

895.08

Formula

C₅₀H₇₀O₁₄

CAS No.

79580-28-2

SMILES
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Keywords:

Brevetoxin BBrevetoxin-2PbTx-2Brevetoxin2Brevetoxin 2PbTx2PbTx 2Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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