1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Brevetoxin B

Brevetoxin B (Synonyms: Brevetoxin-2; PbTx-2)

Cat. No.: HY-12546
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Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.

For research use only. We do not sell to patients.

Brevetoxin B Chemical Structure

Brevetoxin B Chemical Structure

CAS No. : 79580-28-2

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Description

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.

Molecular Weight

895.08

Formula

C₅₀H₇₀O₁₄

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Keywords:

Brevetoxin BBrevetoxin-2 PbTx-2Brevetoxin2Brevetoxin 2PbTx2PbTx 2PbTx-2Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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Brevetoxin B
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HY-12546
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