2. Membrane Transporter/Ion Channel Apoptosis Neuronal Signaling
  3. Sodium Channel Apoptosis Calcium Channel Potassium Channel Caspase
  4. Brevetoxin B

Brevetoxin B  (Synonyms: Brevetoxin-2; PbTx-2)

Cat. No.: HY-12546 Purity: 95.0%
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Brevetoxin B (Brevetoxin-2) is a red tide toxin. Brevetoxin B affects sodium, potassium and calcium currents in nerve terminals. Brevetoxin B also modulates the metabolic activity of Jurkat cells, reduces cell viability and induces apoptosis. Brevetoxin B can be used in research on synaptic transmission and tumors.

For research use only. We do not sell to patients.

Brevetoxin B

Brevetoxin B Chemical Structure

CAS No. : 79580-28-2

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100 μg In-stock

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Based on 1 publication(s) in Google Scholar

Brevetoxin B Related Antibodies

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Description

Brevetoxin B (Brevetoxin-2) is a red tide toxin. Brevetoxin B affects sodium, potassium and calcium currents in nerve terminals. Brevetoxin B also modulates the metabolic activity of Jurkat cells, reduces cell viability and induces apoptosis. Brevetoxin B can be used in research on synaptic transmission and tumors[1][2].

IC50 & Target[2]

Caspase 3

 

Cellular Effect
Cell Line Type Value Description References
C6 EC50
13 μM
Compound: BTXB
Inhibition of MTX-induced 45Ca2+ influx in rat glioma C6 cells
Inhibition of MTX-induced 45Ca2+ influx in rat glioma C6 cells
[PMID: 22560474]
In Vitro

Brevetoxin-B (0.011-1.11 μM; 10 min) concentration-dependently modulates multiple presynaptic ion currents at motor nerve terminals in mouse sternal deltoid muscle preparations: at a concentration of 0.11 μM, it enhances sodium and potassium currents while inhibiting calcium-activated potassium currents and slow calcium currents; at a concentration of 1.11 μM, it inhibits all detected ion currents[1].
Brevetoxin B (0-10 μg/mL; 0-48 h) affects the viability of Jurkat cells, causing a significant concentration- and time-dependent decrease in cellular metabolic activity[2].
Brevetoxin B (0-10 μg/mL; 3 h) significantly induces caspase-3-dependent apoptosis in Jurkat cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Brevetoxin B Related Antibodies

Cell Viability Assay[2]

Cell Line: Jurkat
Concentration: 0, 2, 4, 6, 8 and 10 μg/mL
Incubation Time: 3, 24, 48 h
Result: Remained greater than 94% at all tested concentrations with no significant decrease compared to controls after 3 h.
Significantly decreased compared to controls at concentrations of 1.25 μg/mL or greater after 24 h.
Dropped to less than 30% at all tested concentrations after 48 h.
Molecular Weight

895.08

Formula

C50H70O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1(O[C@](C)(CC[C@@](O[C@@](C[C@](C)(O[C@@](C(C)=CC2=O)([H])[C@](O2)([H])C3)[C@]3([H])O4)([H])[C@]4([H])C5)([H])[C@]([C@@H]5C)([H])O6)[C@]6([H])C7)[C@]7([H])O[C@]8(C)[C@@](O[C@](C[C@](O[C@@](C)([C@H]9O)[C@@](O[C@H](CC(C=O)=C)C9)([H])C%10)([H])[C@@]%10([H])O%11)([H])[C@@]%11([H])/C=C\C8)([H])C1
Structure Classification
Initial Source

Austrovenus stutchburyi
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 95%

SDS (480 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References
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Brevetoxin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brevetoxin B79580-28-2Brevetoxin-2 PbTx-2Brevetoxin2Brevetoxin 2PbTx2PbTx 2PbTx-2Sodium ChannelApoptosisCalcium ChannelPotassium ChannelCaspaseNa channelsNa+ channelsCa2+ channelsCa channelsKcsAsodium channelsmouse skeletal muscleapoptosiscaspase-3Jurkat cellscalcium channelsInhibitorinhibitorinhibit

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