2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse Siglec-H Antibody (440c)

Anti-Mouse Siglec-H Antibody (440c) 

Cat. No.: HY-P990163 Pureza: 98.45%
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Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis.

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Anti-Mouse Siglec-H Antibody (440c)

Anti-Mouse Siglec-H Antibody (440c) Estructura química

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Anti-Mouse Siglec-H Antibody (440c) Related Antibodies

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Descripciòn

Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis[1][2].

Isotype

Rat IgG2b
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

Siglec-H
In Vitro

Anti-Mouse Siglec-H Antibody (440c) (24 h) blocks secretion of IFN-α by murine interferon–producing cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Siglec-H Antibody (440c) Related Antibodies
In Vivo

Anti-Mouse Siglec-H Antibody (440c) (200 μg, i.p., every 24 h for 1-2 times) reduces serum levels of IFN-α and does not deplete interferon–producing cells in 129/SvJ mice[1].
Anti-Mouse Siglec-H Antibody (440c) (200 μg, i.p., very other day) blocks the plasmacytoid DCs functional response to Toll like receptors stimulation and therapeutic effects of GM-CSF in Dextran sulfate sodium salt (DSS) (HY-116282C)-induced colitis mice models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dextran sulphate sodium (DSS) (HY-116282C)-induced colitis mice models[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, every other day companied with GM-CSF
Result: Blocked the plasmacytoid DCs functional response to Toll like receptors stimulation and therapeutic effects of GM-CSF.
Gene ID

233274  [NCBI]

Accession
Application

in vivo administration; Flow cytometry
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse Siglec-H Antibody (440c)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Anti-Mouse Siglec-H Antibody (440c) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Siglec-H Antibody (440c)Transmembrane GlycoproteinSiglec-HPlasmacytoid DCsInterferon–producing cellsColitisIFN-αDextran sulphate sodiumInhibitorinhibitorinhibit

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Nombre del producto:
Anti-Mouse Siglec-H Antibody (440c)
Cat. No.:
HY-P990163
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