Anti-Mouse Siglec-H Antibody (440c)
Based on 1 Customer Validation
Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis.
For research use only. We do not sell to patients.
- Purity : 98.45%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2b
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
Siglec-H
In Vitro
Anti-Mouse Siglec-H Antibody (440c) (24 h) blocks secretion of IFN-α by murine interferon–producing cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Mouse Siglec-H Antibody (440c) (200 μg, i.p., very other day) blocks the plasmacytoid DCs functional response to Toll like receptors stimulation and therapeutic effects of GM-CSF in Dextran sulfate sodium salt (DSS) (HY-116282C)-induced colitis mice models[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dextran sulphate sodium (DSS) (HY-116282C)-induced colitis mice models[2]
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Dosage:200 μg
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Administration:Intraperitoneally injection, every other day companied with GM-CSF
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Result:Blocked the plasmacytoid DCs functional response to Toll like receptors stimulation and therapeutic effects of GM-CSF.
Gene ID
233274 [NCBI]
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo administration; Flow cytometry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse Siglec-H Antibody (440c)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Blasius A, et al. A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha. Blood. 2004 Jun 1;103(11):4201-6. [Content Brief]
[2]. Sainathan SK, et al. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm Bowel Dis. 2008 Jan;14(1):88-99. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse Siglec-H Antibody (440c) Related Classifications
HY-P990163 Related Classifications
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