Search Result

Results for "

BChE inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Aldehyde Dehydrogenase (ALDH) (1) AMPK (1) Amylases (1) Amyloid-β (16) Antibiotic (1) Apoptosis (11) ATP Citrate Lyase (1) Bacterial (2) Bcl-2 Family (2) Beta-secretase (8) Biochemical Assay Reagents (1) Calcium Channel (1) Cannabinoid Receptor (3) Carbonic Anhydrase (6) Caspase (2) CDK (1) Cholinesterase (ChE) (204) COX (2) Cytochrome P450 (3) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (2) Environmental Pollutants (1) FAAH (1) Fluorescent Dye (1) Free Fatty Acid Receptor (1) Fungal (3) Glycosidase (4) GSK-3 (4) HDAC (2) Histamine Receptor (2) Histone Acetyltransferase (2) HIV (1) HSP (1) iGluR (4) IKK (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (5) Isotope-Labeled Compounds (5) JNK (4) Keap1-Nrf2 (2) mAChR (2) Mitochondrial Metabolism (1) MMP (3) Monoamine Oxidase (24) MyD88 (1) nAChR (1) Necroptosis (2) NF-κB (6) NOD-like Receptor (NLR) (4) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (7) Parasite (2) PERK (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Potassium Channel (2) Reactive Oxygen Species (ROS) (10) Reference Standards (13) ROS Kinase (3) SARS-CoV (1) Sigma Receptor (1) SOD (1) Tau Protein (6) TGF-beta/Smad (2) TGF-β Receptor (1) TNF Receptor (4) Toll-like Receptor (TLR) (1) Topoisomerase (1) TRP Channel (4) Tyrosinase (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (5) Endocrinology (1) Infection (8) Inflammation/Immunology (21) Metabolic Disease (13) Neurological Disease (186)
Click Chemistry:	Alkynes (1)

214

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10488

BChE-IN-11	Cholinesterase (ChE)	Neurological Disease
BChE-IN-11 (compound 10) is a potent, selective and non-competitive *BChE* (butyrylcholinesterase) inhibitor, with an IC₅₀ of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research .

HY-155140

BChE-IN-17	Cholinesterase (ChE)	Neurological Disease
BChE-IN-17 (compound 6n) is a potent and selective *BChE* inhibitor with IC₅₀s of 10.5 nM and 32.5 nM for eqBChE and hBChE, respectively. BChE-IN-17 shows over 1000-fold selectivity to BChE against AChE. BChE-IN-17 shows low neurotoxicity and moderate neuroprotective effects .

HY-159977

1,2-Didehydrotanshinone IIA	Cholinesterase (ChE) Indoleamine 2,3-Dioxygenase (IDO)	Others
1,2-Didehydrotanshinone IIA is a moderate AChE and *BChE* inhibitor, with an IC₅₀ value of 5.98 μM for BChE . 1,2-Didehydrotanshinone IIA is a IDO inhibitor, with an IC₅₀ value of 4.68 µM μM .

HY-157982

BChE-IN-28	Cholinesterase (ChE)	Neurological Disease
BChE-IN-28 (compound 6J) is a selective butyrylcholinesterase (BChE) inhibitor with an IC₅₀ of 8 nM and a K_i of 12.16 nM. BChE-IN-28 shows the lower inhibition against AChE, MAO-A and MAO-B .

HY-178356

BChE-IN-44	Cholinesterase (ChE) nAChR Interleukin Related TNF Receptor	Neurological Disease Inflammation/Immunology
BChE-IN-44 is a potent, brain-penetrant, highly selective *BChE* inhibitor [equine BChE IC₅₀ = 18.00 pM, human BChE IC₅₀ = 1.50 nM]. BChE-IN-44 shows neuroprotective effects against the Aβ_1-42-induced injury model and inhibitory effects on Aβ_1-42 self-aggregation. BChE-IN-44 reduces the levels of inflammatory factors (NO, IL-6, and TNF-α) in Lipopolysaccharides (HY-D1056)-induced BV2 cells. BChE-IN-44 can significantly ameliorate Scopolamine (HY-N0296)-induced cognition impairment. BChE-IN-44 exhibits capacity in the regulation of *BChE* and acetylcholine levels in the mouse hippocampus. BChE-IN-44 can be used for the study of Alzheimer’s disease (AD) .

HY-175973

AChE/BChE-IN-30	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-30 (Compound 3g) is a Cholinesterase dual-target competitive inhibitor. AChE/BChE-IN-30 can inhibit AChE and *BChE* with IC₅₀ values of 0.338 and 2.087 μM and K_i values of 0.045 and 0.789 μM. AChE/BChE-IN-30 can be used for the research of neurological disease, such as Alzheimer's disease .

HY-179126

BChE/MAO-A-IN-1	Cholinesterase (ChE) Monoamine Oxidase	Inflammation/Immunology
BChE/MAO-A-IN-1 (compound 7j) is a *BChE/MAO-A* inhibitor. BChE/MAO-A-IN-1 exhibits inhibitory activity against BChE (IC₅₀ = 0.03 nM) and MAO-A (IC₅₀ = 0.32 nM), while also having inhibitory effects on MAO-B. BChE/MAO-A-IN-1 has good anti glycation, antioxidant activity, and low cytotoxicity. BChE/MAO-A-IN-1 can be used in the research of diabetes and Alzheimer's disease .

HY-178017

BChE/hCA II-IN-1	Cholinesterase (ChE) Carbonic Anhydrase	Neurological Disease
BChE/hCA II-IN-1 (Compound 20) is a dual-functional inhibitor of Butyrylcholinesterase (BChE) and human carbonic anhydrase II (hCA II) with IC₅₀s of 76.50 and 10.69  μM for BChE and hCA II, respectively. BChE/hCA II-IN-1 can be used for neurodegenerative diseases like Alzheimer's and glaucoma research .

HY-W272207

AChE/BChE-IN-31	Cholinesterase (ChE) Drug Intermediate	Neurological Disease Inflammation/Immunology
AChE/BChE-IN-31 (Compound 3c) is a cholinesterase inhibitor. AChE/BChE-IN-31 exhibits certain inhibitory activity against hAChE and eqBChE. AChE/BChE-IN-31 also possesses antioxidant properties with an IC₅₀ value of 105.04 μM against DPPH. AChE/BChE-IN-31 can be used in the research of diseases such as Alzheimer’s disease .

HY-178433

BChE/p38-α MAPK-IN-2	Cholinesterase (ChE) p38 MAPK	Neurological Disease
BChE/p38-α MAPK-IN-2 is a *BChE* and p38-α MAPK dual inhibitor. BChE/p38-α MAPK-IN-2 inhibits hBChE with an IC₅₀ of 5.1 nM, showing 1000-fold selectivity over hAChE. BChE/p38-α MAPK-IN-2 inhibits p38α MAPK with an IC₅₀ of 8.12 μM. BChE/p38-α MAPK-IN-2 exhibits neuroprotective effect and can be used for the research of neurological disease, such as Alzheimer’s disease .

HY-179363

BChE-IN-46	Cholinesterase (ChE) COX	Neurological Disease
BChE-IN-46 is a selective and brain-penetrant *BChE* inhibitor (eqBChE IC₅₀ = 7.44 × 10 ⁻⁵ μM, SI > 270,000; hBChE, IC₅₀ = 1.48 × 10 ⁻³ μM). BChE-IN-46 has COX-2 inhibitory activity (IC₅₀ = 0.11 μM). BChE-IN-46 exhibits neuroprotective effects, enhances acetylcholine levels, and alleviates cognitive deficits, anxiety, and learning/memory impairments. BChE-IN-46 can be used for the development of anti-Alzheimer's disease drugs .

HY-162138

BChE-IN-23	Cholinesterase (ChE)	Neurological Disease
BChE-IN-23 (compound 2a) is a *BChE* inhibitor with an IC₅₀ value of 21 nM. BChE-IN-23 can be used in Alzheimer's disease (AD) research .

HY-163883

BChE-IN-34	Cholinesterase (ChE)	Neurological Disease
BChE-IN-34 is a potent and selective butyrylcholinesterase (BChE) inhibitor with an IIC₅₀ of 25 nM. BChE-IN-34 shows excellent selectivity against BChE over acetylcholinesterase. BChE-IN-34 has neuroprotective and antioxidant effects .

HY-161311

AChE/BChE-IN-18	Cholinesterase (ChE) Cannabinoid Receptor	Neurological Disease
AChE/BChE-IN-18 (Compound 4g) is a dual inhibitor of AChE/BChE , with a IC₅₀ value of 0.315 μM for AchE. AChE/BChE-IN-18 is also a CB2R antagonist with a K_i value of 31 nM. AChE/BChE-IN-18 has neuroprotective activity .

HY-175211

BChE-IN-42	Cholinesterase (ChE)	Neurological Disease
BChE-IN-42 (Compound 4a) is a *BChE* inhibitor with an IC₅₀ of 10.01 nM. BChE-IN-42 can be used for neurological diseases like Alzheimer's disease (AD) research .

HY-157981

AChE-IN-60	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE-IN-60 (compound 6k) is a potant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with IC₅₀s of 27 nM and 43 nM, respectively. AChE-IN-60 also inhibits monoamine oxidase (MAO)-A and MAO-B with IC₅₀s of 353 nM and 716 nM, respectively .

HY-159081

AChE/BChE-IN-20	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-20 (compound 3m) is an acetylcholinesterase (AChE, IC₅₀=34.81 μM) and butylcholinesterase (BChE, IC₅₀=20.66 μM) inhibitor, which has been demonstrated to have affinity for key enzyme pockets and favorable interaction profiles by molecular docking and kinetic simulations, and can be used in the study of Alzheimer's disease .

HY-161331

S16–1029	Cholinesterase (ChE)	Neurological Disease
S16–1029 is a selective and orally active butyrylcholinesterase (BChE) inhibitor with IC₅₀s of 11.35 nM and 48.1 nM for eqBChE and hBChE, respectively. S16–1029 could cross the blood-brain barrier (BBB) and reach the central nervous system (CNS). S16–1029 can be used for Alzheimer's disease (AD) research .

HY-143465

BChE-IN-5	Cholinesterase (ChE)	Neurological Disease
BChE-IN-5 is a potent and selective *BChE* inhibitor of hBChE over hAChE with an IC₅₀ of 2.8 nM for BChE. BChE-IN-5 has the potential for the research of alzheimer’s disease .

HY-169234

BChE-IN-35	Cholinesterase (ChE)	Neurological Disease
BChE-IN-35 (Azo-9) is a *BChE* inhibitor. BChE-IN-35 has a dynamic cis/trans conformational change, where the cis isomer preferentially binds to BChE. BChE-IN-35 can be used in Alzheimer's disease (AD) research .

HY-155368

BChE-IN-20	Cholinesterase (ChE)	Neurological Disease
BChE-IN-20 (compound 7c) is a highly potent *BChE*-selective inhibitor and exhibits IC₅₀s of 105 and 2.3 nM for eqBChE and hBChE, respectively. BChE-IN-20 inhibits P glycoprotein with IC₅₀ of 0.27 μM. BChE-IN-20 is a promising template to improve design and development of BChE-selective ligands of pharmaceutical interest, including inhibitors and fluorogenic probes.

HY-163441

BChE-IN-31	Cholinesterase (ChE)	Neurological Disease
BChE-IN-31 (Compound 14d) is a selective *BChE* inhibitor with an IC₅₀ of 65 nM. BChE-IN-31 inhibits the self-induced aggregation of neurotoxic amyloid-β (Aβ) peptide .

HY-139974

BChE-IN-2	Cholinesterase (ChE)	Neurological Disease
BChE-IN-2 (compound 22) is a potent inhibitor of *BChE* with a Ki of 0.099 μM. BChE-IN-2 is a pyrimidine and pyridine derivative. BChE-IN-2 has the potential for the research of Alzheimer’s disease (AD) .

HY-169961

BChE-IN-38	Cholinesterase (ChE)	Cancer
BChE-IN-38 (compound 13) is a potent *BChE* inhibitor with K_i values of 62.05, 28.78, 14.09, 1.15 nM for hCAI, hCAII, AChE, BChE, respectively. BChE-IN-38 shows cytotoxic activity .

HY-162338

BChE-IN-29	Cholinesterase (ChE)	Neurological Disease
BChE-IN-29 (Compound 27a) is a *BChE* inhibitor (IC₅₀: 0.078 μM and 0.74 μM for BChE and AChE respectively). BChE-IN-29 has anti-inflammatory activity and can be used for research of AD .

HY-155369

BChE-IN-21	Cholinesterase (ChE)	Neurological Disease
BChE-IN-21 is a potent *BChE* inhibitor with an IC₅₀ of 0.14 ± 0.02 μM. BChE-IN-21 has the potential for alzheimer's disease research .

HY-146669

BChE-IN-6	Cholinesterase (ChE)	Neurological Disease
BChE-IN-6 (compound 12) is a potent *BChE* inhibitor, with a K_i of 0.182 μM. BChE-IN-6 shows chelating capacity on Zn ²⁺. BChE-IN-6 can be used for Alzheimer’s disease (AD) research .

HY-163175

BChE-IN-24	Cholinesterase (ChE)	Neurological Disease
BChE-IN-24 is a selective and reversible *BChE* inhibitor with an IC₅₀ of 9 nM. BChE-IN-24 can be used for the research of Alzheimer’s disease and related neurodegenerative disorders .

HY-146313

BChE-IN-7	Cholinesterase (ChE)	Neurological Disease
BChE-IN-7 (compound 13) is a potent, selective, BBB-penetrated and reversible AChE and *BChE* inhibitor, with an IC₅₀ of 0.06 μM (BChE). BChE-IN-7 can protect neuronal-like cells from toxic Aβ-species .

HY-146665

AChE/BChE-IN-5	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-5 (BMC-16) is a dual AChE and *BChE* inhibitor with IC₅₀ values of 266 nM and 10.6 nM against human AChE (hAChE) and human BChE (hBChE), respectively. AChE/BChE-IN-5 can cross the BBB .

HY-143464

BChE-IN-4	Cholinesterase (ChE)	Neurological Disease
BChE-IN-4 is a potent and cross the blood-brain barrier *BChE* inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease .

HY-161508

AChE/BChE-IN-19	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-19 (Compound 12) is a nicotinic hydrazide derivative. AChE/BChE-IN-19 is a inhibitor of AChE (IC₅₀ = 21.45 nM) and *BChE* (IC₅₀ =18.42 nM). AChE/BChE-IN-19 can be used in Alzheimer's disease research .

HY-157520

BChE-IN-25	Cholinesterase (ChE)	Others
BChE-IN-25 (compound 4I) is a selective *BChE* inhibitor (IC₅₀: 3.77μM), which is 22 times more selective for BChE than AChE .

HY-N10701

AChE/BChE-IN-11	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-11 (compound 1) is a potent is a dual AChE and *BChE* inhibitor with IC₅₀ values of 70 and 71 μM for AChE and BChE, respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of artichoke . AChE/BChE-IN-11 can be used in research of Alzheimer’s disease (AD) research .

HY-N10489

BChE-IN-12	Cholinesterase (ChE)	Neurological Disease
BChE-IN-12 (compound 12) is a potent butyrylcholinesterase (BChE) non-competitive inhibitor with an IC₅₀ value of 2.3 μM. BChE-IN-12 can be isolated from Bletilla striata. BChE-IN-12 can be used for the research of Alzheimer's disease (AD) .

HY-N10486

BChE-IN-10	Cholinesterase (ChE)	Neurological Disease
BChE-IN-10 (compound 6) is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC₅₀ value of 6.4 μM. BChE-IN-10 can be isolated from Bletilla striata. BChE-IN-10 can be used for the research of Alzheimer's disease (AD) .

HY-149484

AChE/BChE-IN-15	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-15 (Compound 6d) is an *AChE/BChE* inhibitor, with IC₅₀s of 20 nM and 220 nM respectively. AChE/BChE-IN-15 binds to both catalytic anionic site (CAS) and peripheral anionic site (PAS) in the active sites of AChE and BChE. AChE/BChE-IN-15 can be used for research of Alzheimer’s disease .

HY-144753

AChE/BChE-IN-2	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-2 (Compound 13b) is a potent inhibitor of *AChE/BChE* (AChE IC50 = 0.96 ± 0.14 µM, BChE IC50 = 1.23 ± 0.23 µM). AChE/BChE-IN-2 has the potential for the research of AD diseases .

HY-161150

AChE/BChE-IN-17	Cholinesterase (ChE) Glycosidase	Neurological Disease Metabolic Disease
AChE/BChE-IN-17 (compound 8m) is a potent and non-competitiveAChE and *BChE* inhibitor, with IC₅₀ values of 125.06 nM and 119.68 nM, respectively. AChE/BChE-IN-17 also inhibits α-glucosidase, with an IC₅₀ of 41050 nM .

HY-159898

AChE/BChE-IN-23	Cholinesterase (ChE) Amyloid-β Tau Protein NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Neurological Disease
AChE/BChE-IN-23 (Compound 6e) is an *AChE/BChE* inhibitor (IC₅₀: 0.91 μM, 1.19 μM and 1.01 μM for hAChE, eq BChE and hBChE, respectively). AChE/BChE-IN-23 has antioxidant activity and inhibits Aβ1-42 and Tau protein aggregation. AChE/BChE-IN-23 also inhibits microglial activation by reducing ROS release and mitochondrial injury. AChE/BChE-IN-23 suppresses NLRP3 inflammasome and pro-inflammatory cytokines in human microglial cells. AChE/BChE-IN-23 also reverses the Scopolamine (HY-N0296)-induced memory impairment in mice model .

HY-179122

BChE-IN-45	Cholinesterase (ChE)	Neurological Disease
BChE-IN-45 (compound 4p) is a competitive (cholinesterase) dual acting inhibitor (K_i = 11.13 μM). BChE-IN-45 has an IC₅₀ of 13.8 μM for BChE and 35.63 μM for AChE. BChE-IN-45 can be used for research on Alzheimer's disease .

HY-174464

AChE/BChE-IN-28	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-28 (Compound 5q) is a *BChE* inhibitor with an IC₅₀ of 13.49 μM. AChE/BChE-IN-28 also exerts moderate inhibitory effect on AChE, with an IC₅₀ of 35.23 μM. AChE/BChE-IN-28 can be used in the research of Alzheimer's disease .

HY-144689

BChE-IN-3	Cholinesterase (ChE)	Neurological Disease
BChE-IN-3 (compound 45a) is a potent, selective, time-dependent and pseudoirreversible *BChE* inhibitor, with an IC₅₀ of 56.9 nM. BChE-IN-3 also shows marginal and reversible (not time-dependent) inhibition of AChE .

HY-146668

AChE/BChE-IN-8	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-8 (Compound 5a) is an uncompetitive AChE and mixed *BChE* inhibitor with K_i values of 0.788 μM and 2.364 μM against Electrophorus electricus AChE (EeAChE) and *equine BChE* (eqBChE)*, respectively. AChE/BChE*-IN-8 can cross the BBB and has low cytotoxicity .

HY-151368

AChE/BChE-IN-10	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and *BChE* inhibitor with IC₅₀ values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research .

HY-152232

BChE-IN-15	Cholinesterase (ChE)	Cancer
BChE-IN-15 (Compound 6) is a pseudo-irreversible and covalent *BChE* inhibitor with an IC₅₀ of 1.76 nM against hBChE .

HY-161156

BChE-IN-26	Cholinesterase (ChE)	Neurological Disease Cancer
BChE-IN-26 (Compound 7b) is a selective AChE and *BChE* inhibitor with K_i value of 35 μM and 1.6 μM. BChE-IN-26 has cytotoxicity to human neuroblastoma (SH-SY5Y) cell line. BChE-IN-26 can be used for the research of Alzheimer’s disease .

HY-159880

AChE/BChE-IN-24	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-24 (compound 5k) is a neuroprotective agent through cholinesterase inhibition. AChE/BChE-IN-24 inhibits AChE and *BChE* with IC₅₀ values of 16.38 μM and 10.44 μM, respectively .

HY-147880

BChE-IN-9	Cholinesterase (ChE)	Neurological Disease
BChE-IN-9 (Azepano-11-deoxo-glycyrrhetol) is a mixed type *BChE* inhibitor with a K_i of 0.21 µM .

HY-170389

BChE-IN-39	Cholinesterase (ChE)	Neurological Disease
BChE-IN-39 (Compound 7c) is a selective inhibitor for butyrylcholinesterase (BChE) with an IC₅₀ of 0.08 μM (IC₅₀=3.98 μM for AChE). BChE-IN-39 downregulates the GSK-3β expression, inhibits the hyperphosphorylation of tau protein .

Cat. No.	Product Name	Type

HY-W324391

Coumarin 106 Coumarin 478	Fluorescent Dyes
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC₅₀=4.97 and K_i=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC₅₀=4.56) .

HY-103373

PE154	Fluorescent Dyes
PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC₅₀s=280 pM and 16 nM, respectively) . PE154 can label β-amyloid plaques in histochemical analysis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992076

Anti-Candida auris β-1, 3 glucans Antibody (2G8)	TGF-β Receptor TGF-beta/Smad Cholinesterase (ChE) Fungal	Infection Cancer
Anti-Candida auris β-1,3-glucans Antibody (2G8) is an antibody targeting Candida auris β-1,3-glucans, and also acts as an inhibitor of AChE and TGF-β receptor 2. Anti-Candida auris β-1,3-glucans Antibody (2G8) also targets fungal cell wall components, effectively inhibits fungal growth and interferes with capsule formation, thereby significantly reducing the fungal load in mouse tissues. Anti-Candida auris β-1,3-glucans Antibody (2G8) not only blocks TGF-β receptor binding to inhibit the Smad signaling pathway, reduces fibroblast activation and collagen deposition, but also induces epithelial differentiation of tumor cells and reduces pancreatic tumor metastasis. Anti-Candida auris β-1,3-glucans Antibody (2G8) specifically binds to the conserved N-linked glycoepitope on AChE to inhibit its activity without interfering with *BChE*, and can be used in studies of cryptococcosis and related tumor mechanisms .The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0285

Imperatorin 5 Publications Verification Ammidin	Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Source Classification	Cholinesterase (ChE) TRP Channel
Imperatorin is an effective of NO synthesis inhibitor (IC₅₀=9.2 μmol), which also is a *BChE* inhibitor (IC₅₀=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC₅₀ of 12.6±3.2 μM.

HY-107569

Garcinol 5 Publications Verification	Classification of Application Fields Guttiferae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Garcinia indica	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 μM and 7.39 μM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-N0226A

Epiberberine chloride 4 Publications Verification	Alkaloids Neurological Disease Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species (ROS)
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and *BChE* inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .

HY-N0226

Epiberberine	Alkaloids Structural Classification Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Source Classification	Cholinesterase (ChE) Beta-secretase
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and *BChE* inhibitor, and a non-competitive BACE1 inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease . Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberinecan be used for the research of diabetic disease .

HY-N2157

Pteryxin 1 Publications Verification (+)-Pteryxin	Coumarins Phenylpropanoids Umbelliferae Plants Achillea atrata L. Source Classification	Cholinesterase (ChE) NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS) Nuclear Factor of activated T Cells (NFAT) p38 MAPK
Pteryxin ((+)-Pteryxin) is an orally active multi-target inhibitor that targets NF-κB, MAPK, NLRP3 inflammasome, and Nrf2/ARE pathways. Pteryxin is also a *BChE* inhibitor (IC₅₀=12.96 μg/mL) with a low inhibitory efficiency on AChE. Pteryxin inhibits the Ca ²⁺-calcineurin-NFATc1 pathway by blocking NF-κB/MAPK signaling, inhibiting NLRP3 inflammasome activation, and reducing ROS generation, and activates Nrf2-mediated antioxidant enzyme expression. Pteryxin has anti-inflammatory, antioxidant, and osteoclastogenesis inhibitory activities. Pteryxin can be used in the study of inflammatory diseases, osteoporosis, diabetes, and Alzheimer's disease .

HY-N3266

Methyl rosmarinate	Structural Classification Classification of Application Fields Simple Phenylpropanols Adenocarpus cincinnatus (Ball) Maire Labiatae Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Tyrosinase Phosphatase Cholinesterase (ChE) SARS-CoV PERK JNK p38 MAPK TGF-beta/Smad Apoptosis Reactive Oxygen Species (ROS) AMPK MMP
Methyl rosmarinate is an orally active hydroxycinnamic acid. Methyl rosmarinate exhibits an IC₅₀ of 24.70 μM and a K_i of 15.29 μM against PTP1B, an IC₅₀ of 41.46 μg/mL against *BChE, a K_i* of 0.61 mM against mushroom tyrosinase, and an IC₅₀ of 2.50 μM against SARS-CoV-2 3CLpro. Methyl rosmarinate downregulates the phosphorylation levels of ERK, JNK, p38, Smad2 and Smad3. Methyl rosmarinate activates erythrocyte BPGM and promotes the production of 2,3-BPG. Methyl rosmarinate induces apoptosis of fibroblasts. Methyl rosmarinate prolongs the survival time of hypoxic mice. Methyl rosmarinate improves insulin sensitivity. Methyl rosmarinate binds to SARS-CoV-2 3CLpro and inhibits viral replication. Methyl rosmarinate induces glioblastoma cell death. Methyl rosmarinate activates the TGR5/AMPK axis and reduces the levels of ROS and MDA. Methyl rosmarinate shows inhibitory activity against MMP-1. Methyl rosmarinate can be used in research related to pulmonary fibrosis, hypoxia-induced injury, type 2 diabetes, Alzheimer's disease, hyperpigmentation disorders, COVID-19, glioblastoma and myocardial ischemia-reperfusion injury .

HY-N2960

Broussonin A	Phenols Polyphenols Plants Moraceae Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat Source Classification	Cholinesterase (ChE)
Broussonin A is a potent *BChE* inhibitor, with an IC₅₀ of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation .

HY-N2129

N-Nornuciferine 1 Publications Verification	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Metabolic Disease Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae Disease Research Fields Source Classification	Cytochrome P450 Cholinesterase (ChE)
N-Nornuciferine is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC₅₀ of 3.76 μM and a K_i of 2.34 μM against human CYP2D6. N-Nornuciferine also acts as a *BChE* inhibitor, showing an IC₅₀ of 5.6 μM in mice . N-Nornuciferine can be used in the research of neurological-related diseases .

HY-121382

Gypsogenin	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Disease Research Fields Caryophyllaceae Source Classification Gypsophila perfoliata Linn.	Cholinesterase (ChE) Apoptosis Necroptosis
Gypsogenin is a selective mixed-type *BChE* inhibitor (K_i=19.99 μM) that also exhibits significant cytotoxicity against various human cancer cell lines. Gypsogenin inhibits tumor growth by inducing cell cycle arrest and triggering apoptosis. Gypsogenin displays antibacterial activity against bacteria such as Bacillus subtilis and Bacillus thuringiensis, and often serves as a key parent nucleus for the synthesis of anticancer compounds. Gypsogenin is widely used in research on Alzheimer's disease and various cancers including colon cancer, melanoma, and leukemia .

HY-N6009

8-Deoxygartanin	Infection other families Xanthones Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Parasite NF-κB
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-N2284

Sophoflavescenol	Flavonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Sophora flavescens Aiton Plants Disease Research Fields Source Classification Cancer	Cholinesterase (ChE) Beta-secretase Phosphodiesterase (PDE)
Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC₅₀ of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC₅₀s of 0.30 μM, 0.17 μM, 17.89 μg/mL, 10.98 μM, 8.37 μM and 8.21 μM, respectively.

HY-N0285R

Imperatorin (Standard) Ammidin (Standard)	Structural Classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Source Classification	Reference Standards Cholinesterase (ChE) TRP Channel
Imperatorin (Standard) is the analytical standard of Imperatorin. This product is intended for research and analytical applications. Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.

HY-N10488

BChE-IN-11	Bletilla striata (Thunb. ex Murray) Rchb. f. Orchidaceae Polyphenols Plants Source Classification	Cholinesterase (ChE)
BChE-IN-11 (compound 10) is a potent, selective and non-competitive *BChE* (butyrylcholinesterase) inhibitor, with an IC₅₀ of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research .

HY-108048

Desoxypeganine Deoxypeganine; Deoxyvasicine	Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Quinoline Alkaloids Plants Source Classification	Cholinesterase (ChE) Monoamine Oxidase
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research .

HY-N6865

Groenlandicine 2 Publications Verification	Structural Classification Classification of Application Fields Ranunculaceae Metabolic Disease Plants Alkaloids Piperidine Alkaloids Monophenols Coptis chinensis Franch. Phenols Isoquinoline Alkaloids Disease Research Fields Source Classification	Cholinesterase (ChE) Topoisomerase Reactive Oxygen Species (ROS) Beta-secretase Apoptosis
Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor (AChE (IC₅₀ = 0.54 μM), *BChE* (IC₅₀ = 3.32 μM)). Groenlandicine non-competitively inhibits BACE1 (IC₅₀ = 19.68 μM, K_i = 21.2) and inhibits RLAR (IC₅₀ = 140.1 μM), HRAR (IC₅₀ = 154.2 μM), and total ROS generation (IC₅₀ = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394). Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus .

HY-N1151

Thunberginol C	Structural Classification Hydrangeaceae Coumarins Phenylpropanoids Plants Source Classification	Bacterial Cholinesterase (ChE) MMP TNF Receptor
Thunberginol C is an orally active, selective, and non-competitive inhibitor of AChE and *BChE, with IC₅₀* values of 41.96 and 42.36 μM, respectively. Thunberginol C exerts cytoprotective, pro-collagen type I restorative, MMP-1 inhibitory, hyaluronic acid restorative, anti-photoaging effects in skin cells. Thunberginol C exerts neuroprotective, anxiolytic, TNF-α inhibitory, neuroinflammation inhibitory, and oxidative stress inhibitory effects. Thunberginol C can be used for the research of Alzheimer’s disease, UVB-induced skin photoaging, allergic reactions, oral bacterial infections, and stress-induced anxiety .

HY-127087

Isogarcinol Cambogin	Guttiferae Phenols Polyphenols Plants Symphonia globulifera L.f. Source Classification	Cholinesterase (ChE) Parasite
Isogarcinol (Cambogin) is a potent AChE and *BChE* inhibitor, with IC₅₀ values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC₅₀ of 0.33 μM against L. donovani .

HY-N12581

Kuwanon U	Flavonoids Flavonones Morus alba L. Plants Moraceae Source Classification	Cholinesterase (ChE)
Kuwanon U is a potent cholinesterase inhibitor with IC₅₀s of 19.69, 10.11 µM and K_is of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD) .

HY-N15710

Magnotriol B	Magnoliaceae Houpoea officinalis (Rehder & E. H. Wilson) N. H. Xia & C. Y. Wu Phenols Polyphenols Plants Source Classification	Cholinesterase (ChE)
Magnotriol B is a cholinesterase inhibitor with IC₅₀ values of 12.63 nM and 14.5 nM against AChE and *BChE, respectively. Magnotriol B also exhibits significant NO inhibitory activity with an IC₅₀* of 2.02 μM. Magnotriol B can be used in the research of neurodegenerative and inflammatory diseases .

HY-107569R

Garcinol (Standard)	Structural Classification Guttiferae Phenols Polyphenols Plants Garcinia indica	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite Reference Standards
Garcinol (Standard) is the analytical standard of Garcinol. This product is intended for research and analytical applications. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-N10701

AChE/BChE-IN-11	Oleaceae Syringa oblata Lindl. Plants Saccharides Monosaccharides Source Classification	Cholinesterase (ChE)
AChE/BChE-IN-11 (compound 1) is a potent is a dual AChE and *BChE* inhibitor with IC₅₀ values of 70 and 71 μM for AChE and BChE, respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of artichoke . AChE/BChE-IN-11 can be used in research of Alzheimer’s disease (AD) research .

HY-N10489

BChE-IN-12	Bletilla striata (Thunb. ex Murray) Rchb. f. Orchidaceae Polyphenols Plants Source Classification	Cholinesterase (ChE)
BChE-IN-12 (compound 12) is a potent butyrylcholinesterase (BChE) non-competitive inhibitor with an IC₅₀ value of 2.3 μM. BChE-IN-12 can be isolated from Bletilla striata. BChE-IN-12 can be used for the research of Alzheimer's disease (AD) .

HY-N10486

BChE-IN-10	Bletilla striata (Thunb. ex Murray) Rchb. f. Classification of Application Fields Neurological Disease Orchidaceae Phenols Polyphenols Plants Disease Research Fields Source Classification	Cholinesterase (ChE)
BChE-IN-10 (compound 6) is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC₅₀ value of 6.4 μM. BChE-IN-10 can be isolated from Bletilla striata. BChE-IN-10 can be used for the research of Alzheimer's disease (AD) .

HY-N8764

Decaffeoylacteoside Decaffeoylverbascoside; Verbasoside	Labiatae Phenols Polyphenols Plants Source Classification Ambrosia hispida	Monoamine Oxidase Cholinesterase (ChE)
Decaffeoylacteoside is an inhibitor of *AChE/BChE/LOX* with moderate activity .

HY-N10487

Bleformin A	Bletilla striata (Thunb. ex Murray) Rchb. f. Orchidaceae Polyphenols Plants Source Classification	Cholinesterase (ChE)
Bleformin A is a potent *BChE* inhibitor with an IC₅₀ value of 5.2 μM. Bleformin A is a nature product that could be isolated from Bletilla striata. Bleformin A can be used for research of Alzheimer's disease (AD) .

HY-N12075

Dehydrodiscretamine chloride	Alkaloids Piperidine Alkaloids Nandina domestica Thunb. Fissistigma polyanthum (Hook. f. et Thoms.) Merr. Plants Annonaceae Berberidaceae Source Classification	Cholinesterase (ChE)
Dehydrodiscretamine chloride is a dual inhibitor of AChE and *BChE* with IC₅₀s of 17.8 and 118.8 μM, respectively. Dehydrodiscretamine chloride has antioxidant activity. Dehydrodiscretamine chloride can be used in study Alzheimer’s disease .

HY-N10490

Blestrin D	Bletilla striata (Thunb. ex Murray) Rchb. f. Orchidaceae Polyphenols Plants Source Classification	Cholinesterase (ChE)
Blestrin D is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC₅₀ value of 8.1 μM. Blestrin D can be isolated from Bletilla striata. Blestrin D can be used for the research of Alzheimer's disease (AD) .

HY-121382R

Gypsogenin (Standard)	Triterpenes Structural Classification Terpenoids Plants Caryophyllaceae Source Classification Gypsophila perfoliata Linn.	Reference Standards Apoptosis Cholinesterase (ChE) Necroptosis
Cinosulfuron (Standard) is the analytical standard of Cinosulfuron. This product is intended for research and analytical applications. Gypsogenin is a selective mixed-type *BChE* inhibitor (K_i=19.99 μM) that also exhibits significant cytotoxicity against various human cancer cell lines. Gypsogenin inhibits tumor growth by inducing cell cycle arrest and triggering apoptosis. Gypsogenin displays antibacterial activity against bacteria such as Bacillus subtilis and Bacillus thuringiensis, and often serves as a key parent nucleus for the synthesis of anticancer compounds. Gypsogenin is widely used in research on Alzheimer's disease and various cancers including colon cancer, melanoma, and leukemia .

HY-N19871

Monogynol A	Salvia trichoclada Benth. Triterpenes Structural Classification Terpenoids Labiatae Plants Source Classification	Cholinesterase (ChE)
Monogynol A is an *AChE/BChE* inhibitor found in the aerial parts of Salvia trichoclada Bentham. Monogynol A can be used for the research of alzheimer’s disease .

HY-N17425

Lakoochin C	Structural Classification Monophenols Phenols Artocarpus lakoocha Roxburgh Plants Moraceae Source Classification	Cholinesterase (ChE)
Lakoochin C is an inhibitor of acetylcholinesterase (AChE) (IC₅₀ = 61.86 μM) and butyrylcholinesterase (BChE) (IC₅₀ = 47.21 μM). Lakoochin C may be used in research related to Alzheimer's disease .

HY-N17394

Melineurine	Structural Classification Alkaloids Rutaceae Quinoline Alkaloids Melicope pteleifolia (Champ. ex Benth.) Hartley Plants Source Classification	Cholinesterase (ChE)
Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC₅₀ of 95.3 μM against AChE and an IC₅₀ of 28.0 μM against *BChE*. Melineurine is applicable to the research of Alzheimer's disease .

HY-N2129A

N-Nornuciferine hydrochloride	Structural Classification Alkaloids Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Nymphaeaceae Source Classification	Cytochrome P450 Cholinesterase (ChE)
N-Nornuciferine hydrochloride is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC₅₀ of 3.76 μM and a K_i of 2.34 μM against human CYP2D6. N-Nornuciferine hydrochloride also acts as a *BChE* inhibitor, showing an IC₅₀ of 5.6 μM in mice . N-Nornuciferine hydrochloride can be used in the research of neurological-related diseases .

HY-N9731

6-O-p-Hydroxybenzoylglutinoside	Structural Classification Catalpa bungei C. A. Mey. Phenols Bignoniaceae Plants Source Classification	NF-κB
6-O-p-Hydroxybenzoylglutinoside acts as a selective NF-κB inhibitor that suppresses the transcriptional activity of TNF-α-activated NF-κB (IC₅₀=52.78 μM). 6-O-p-Hydroxybenzoylglutinoside shows no significant inhibitory activity against sEH, AChE, or *BChE. 6-O-p-Hydroxybenzoylglutinoside is a caged chlorinated iridoid glycoside identified from the seeds of Catalpa bungei* (Manchurian catalpa) .

HY-N16715

Monardic acid A	Structural Classification Lignans Phenylpropanoids Plants Pulmonaria officinalis L. Boraginaceae Source Classification	Cholinesterase (ChE)
Monardic acid A is a selective inhibitor of AChE, with an IC₅₀ of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC₅₀ >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases .

HY-107272

Chuanbeinone 22-Epidelavinone	Structural Classification Alkaloids Liliaceae Other Alkaloids Fritillaria pallidiflora Schrenk ex Fisch. & C. A. Mey. Plants Source Classification	Cholinesterase (ChE) Apoptosis Bcl-2 Family Caspase Interleukin Related TNF Receptor Toll-like Receptor (TLR) MyD88 NF-κB p38 MAPK
Chuanbeinone (22-Epidelavinone) is an orally active alkaloid found in Fritillaria pallidiflora. Chuanbeinone shows cytotoxicity against mutiple cancer cells and can induces apoptosis and S phase arrest. Chuanbeinone downregulates Bcl-2, upregulates Bax, and activates caspase-3. Chuanbeinone exerts anti-inflammatory and antitussive effects by reducing pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) production and mRNA expression, and inhibiting TRIF-, MyD88-, NF-κB-, and MAPK-dependent signaling pathways. Chuanbeinone inhibits AChE and *BChE* with IC₅₀ values of 7.7 and 0.7 μM. Chuanbeinone can be used for the researches of lung carcinoma, cough, inflammatory diseases .

HY-N19401

Vescalagin	Structural Classification Phenols Polyphenols Myrciaria dubia (Kunth) McVaugh Myrtaceae Plants Source Classification	Cholinesterase (ChE) Carbonic Anhydrase Glycosidase JNK p38 MAPK
Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a K_i value of 5.87 nM against AChE, 3.89 nM against *BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against α-glucosidase. Vescalagin inhibits* hCA I, hCA II and α-glucosidase in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties .

Cat. No.	Product Name	Chemical Structure

HY-N0285S

Imperatorin-d6
Imperatorin-d6 (Ammidin-d6) is the deuterium labeled Imperatorin. Imperatorin is a BChE inhibitor and HIV-1 replication inhibitor. Imperatorin shows mild activity against Gram-negative bacteria .

HY-17368S1

(Rac)-Rivastigmine-d6

(Rac)-Rivastigmine-d₆ is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-17368S2

Rivastigmine-d3 hydrochloride

Rivastigmine-d₃ hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-W654335

Rivastigmine-d4 tartrate

Rivastigmine-d₄ (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-W654336

(S)-Rivastigmine-d4

(S)-Rivastigmine-d₄ is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

Cat. No.	Product Name		Classification

HY-175524

BChE/MAO-B-IN-2		Alkynes
BChE/MAO-B-IN-2 is a dual inhibitor of *BChE* (IC₅₀ = 0.05 μM, K_i = 0.01 μM) and MAO-B (IC₅₀ = 0.45 μM, K_i = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD) .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks