BChE-IN-15

Cat. No.: HY-152232: Data Sheet Handling Instructions
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BChE-IN-15 (Compound 6) is a pseudo-irreversible and covalent BChE inhibitor with an IC₅₀ of 1.76 nM against hBChE .

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BChE-IN-15 Chemical Structure

CAS No. : 3060336-91-3

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Description

BChE-IN-15 (Compound 6) is a pseudo-irreversible and covalent BChE inhibitor with an IC₅₀ of 1.76 nM against hBChE ^[1].

IC₅₀ & Target^[1]

hBCHE

1.76 nM (IC₅₀)

hAChE

558.6 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	7.1 μM Compound: 6	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay	[PMID: 36586299]
SH-SY5Y	IC₅₀	5.8 μM Compound: 6	Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay	[PMID: 36586299]

In Vitro

BChE-IN-15 (Compound 6) (0.5-50 μM; 48 h) shows cytotoxicity against SH-SY5Y and HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	SH-SY5Y and HepG2 cell lines
Concentration:	0.5-50 μM
Incubation Time:	48 h
Result:	Showed cytotoxicity with IC₅₀s of 5.8 μM and 7.1 μM against SH-SY5Y and HepG2 cells, respectively.

Molecular Weight

371.52

Formula

C₂₂H₃₃N₃O₂

CAS No.

3060336-91-3

SMILES

CN(CC1=CNC2=C(C=CC=C12)OC(N(C)C)=O)CCC3CCCCCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Meden A, et al. Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead. Eur J Med Chem. 2022 Dec 24;247:115048. [Content Brief]

BChE-IN-15 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-153060336-91-3Cholinesterase (ChE)SH-SY5YHepG2Inhibitorinhibitorinhibit

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