BChE-IN-15
BChE-IN-15 (Compound 6) is a pseudo-irreversible and covalent BChE inhibitor with an IC50 of 1.76 nM against hBChE .
For research use only. We do not sell to patients.
- CAS No.: 3060336-91-3
- Formula: C22H33N3O2
- Molecular Weight:371.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
hBCHE 1.76 nM (IC50) |
hAChE 558.6 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
7.1 μM
Compound: 6
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay
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[PMID: 36586299] |
| SH-SY5Y | IC50 |
5.8 μM
Compound: 6
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Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay
Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay
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[PMID: 36586299] |
In Vitro
BChE-IN-15 (Compound 6) (0.5-50 μM; 48 h) shows cytotoxicity against SH-SY5Y and HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:SH-SY5Y and HepG2 cell lines
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Concentration:0.5-50 μM
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Incubation Time:48 h
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Result:Showed cytotoxicity with IC50s of 5.8 μM and 7.1 μM against SH-SY5Y and HepG2 cells, respectively.
Chemical Information
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CAS No. 3060336-91-3
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Molecular Weight 371.52
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Formula C22H33N3O2
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SMILES
CN(CC1=CNC2=C(C=CC=C12)OC(N(C)C)=O)CCC3CCCCCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-15 Related Classifications
HY-152232 Related Classifications
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