BChE-IN-49
BChE-IN-49 is an orally active BChE inhibitor with IC50 values of 0.73 μM and 6.43 μM against BChE and AChE, respectively. BChE-IN-49 reduces AChE levels to inhibit the degradation of acetylcholine. By inhibiting GSK-3β, BChE-IN-49 potently activates the Wnt/β-catenin signaling pathway, exerting potent anti-Aβ, antioxidant, anti-neuroinflammatory and anti-apoptotic effects. BChE-IN-49 can be used in research related to Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C22H18ClNO2S
- Molecular Weight:395.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BChE 0.73 μM () |
AChE 6.43 μM () |
Bax |
Bcl-2 |
IL-1β |
GSK-3β |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (adult male, 300-320 g, AlCl3-induced AD model)[1]
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Dosage:30 mg/kg
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Administration:p.o.; daily; 5 weeks (concurrent with AlCl3 i.p. dosing)
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Result:Effectively reversed the cognitive dysfunction induced by AlCl3 in rats.
Inhibited the key enzyme (BACE1) that generates Aβ to reduce Aβ deposition.
Significantly increased the level of BDNF, which had neuroprotective and repair effects.
Reduced levels of pro-inflammatory cytokines IL-1β and TNF-α.
Effectively inhibited neuronal apoptosis.
Strongly activated the Wnt/β-catenin neuroprotective pathway, while inhibiting its negative regulatory factor GSK-3β.
Significantly reversed the decline in DA, NE and 5-HT levels caused by AlCl3, restoring them by 4.5 times, 2.6 times and 5.6 times respectively.
Chemical Information
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Molecular Weight 395.90
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Formula C22H18ClNO2S
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SMILES
O=C1N(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)OC4=C1C5=C(CCCC5)S4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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