BChE-IN-4
BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease.
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- CAS No.: 2304818-41-3
- Formule: C24H37N3O
- Masse moléculaire:383.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
BChE[1]
BChE-IN-4 (30 mg/kg) dose not induce adverse motor effects in vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Albino Swiss CD-1 mice (Scopolamine-induced memory-impaired CD-1 mice)[1]
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Dosage:10, 20, 30 mg/kg
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Administration:I.p.
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Result:Significantly prolonged the step-through latencies in memory impaired mice.
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Animal Model:18-22 g, C57BL/6J mice[1]
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Dosage:30 mg/kg
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Administration:I.p.
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Result:Did not enhance learning abilities and working memory in the acquisition phase or the short-term memory retrieval on day 5, but did significantly improve long-term memory retrieval, as observed on day 12 of the BM ( Barnes maze) task.
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Animal Model:Mice[1]
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Dosage:30 mg/kg (suspended in 1% Tween 80)
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Administration:I.p
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Result:Neither altered the number of light-beam interruptions in the locomotor activity test nor induced any motor deficits at 6, 18 and 24 rpm in the rotarod test.
Chemical Information
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CAS No. 2304818-41-3
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Masse moléculaire 383.57
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Formule C24H37N3O
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SMILES
O=C(NCCC1CCCCCC1)[C@@H](NCCCC)CC2=CNC3=CC=CC=C23
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-4 Related Classifications
HY-143464 Related Classifications
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