BChE-IN-4
BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 2304818-41-3
- Formula: C24H37N3O
- Molecular Weight:383.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
BChE[1]
BChE-IN-4 (30 mg/kg) dose not induce adverse motor effects in vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Adult male Albino Swiss CD-1 mice (Scopolamine-induced memory-impaired CD-1 mice)[1]
-
Dosage:10, 20, 30 mg/kg
-
Administration:I.p.
-
Result:Significantly prolonged the step-through latencies in memory impaired mice.
-
Animal Model:18-22 g, C57BL/6J mice[1]
-
Dosage:30 mg/kg
-
Administration:I.p.
-
Result:Did not enhance learning abilities and working memory in the acquisition phase or the short-term memory retrieval on day 5, but did significantly improve long-term memory retrieval, as observed on day 12 of the BM ( Barnes maze) task.
-
Animal Model:Mice[1]
-
Dosage:30 mg/kg (suspended in 1% Tween 80)
-
Administration:I.p
-
Result:Neither altered the number of light-beam interruptions in the locomotor activity test nor induced any motor deficits at 6, 18 and 24 rpm in the rotarod test.
Chemical Information
-
CAS No. 2304818-41-3
-
Molecular Weight 383.57
-
Formula C24H37N3O
-
SMILES
O=C(NCCC1CCCCCC1)[C@@H](NCCCC)CC2=CNC3=CC=CC=C23
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-4 Related Classifications
HY-143464 Related Classifications
Powered by Bioz