Z32439948
Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells.
For research use only. We do not sell to patients.
- CAS No.: 920845-86-9
- Formula: C25H26N4O4S
- Molecular Weight:478.56
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
|
BChE 1.4 μM (IC50, [1]) |
In Vitro
Z32439948 (1-5 μM; 48 h) has neuroprotective effects on glutamate (31 mM)-induced SH-SY5Y cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
-
Cell Line:SH-SY5Y, BV2 cells
-
Concentration:1 μM, 2 μM, 5 μM
-
Incubation Time:48 h; with or without 31 mM Glutamate
-
Result:Protected cell from Glutamate induced damage.
Chemical Information
-
CAS No. 920845-86-9
-
Molecular Weight 478.56
-
Formula C25H26N4O4S
-
SMILES
O=C(NCCC1=CNC2=C1C=CC=C2)C3=CC=C(OC)C(S(NCCC4=NC=CC=C4)(=O)=O)=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z32439948 Related Classifications
HY-162340 Related Classifications
Powered by Bioz