1. Neuronal Signaling
  2. Cholinesterase (ChE)
  3. BChE-IN-13

BChE-IN-13 

Cat. No.: HY-151386
Handling Instructions

BChE-IN-13 (Compound 17c) is an orally active, potent and selective Butyrylcholinesterase (BChE) inhibitor with IC50s of 0.22 and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 can improve memory and cognitive impairments, and be used in Alzheimer’s disease (AD) research.

For research use only. We do not sell to patients.

BChE-IN-13 Chemical Structure

BChE-IN-13 Chemical Structure

CAS No. : 2700896-73-5

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Description

BChE-IN-13 (Compound 17c) is an orally active, potent and selective Butyrylcholinesterase (BChE) inhibitor with IC50s of 0.22 and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 can improve memory and cognitive impairments, and be used in Alzheimer’s disease (AD) research[1].

IC50 & Target

IC50: 0.22 μM (eqBChE) 0.016 μM (hBChE)[1]

In Vitro

BChE-IN-13 (5-100 μM; 24 h) shows weak toxicity to SH-SY5Y, PC-12 and HT-22, and shows high mortality to BV2 cells[1].
BChE-IN-13 shows excellent blood brain barrier permeation using a parallel artificial membrane permeability assay experiment (PAMPA)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y, PC12, BV2 and HT-22 cells
Concentration: 5-100 μM
Incubation Time: 24 hours
Result: Showed cells viability more than 60% of SH-SY5Y, PC-12 and HT-22 even at 100 μM. Showed high mortality in BV2 cells, and reached half the mortality at 20 μM.
In Vivo

BChE-IN-13 (oral gavage; 15 mg/kg; once daily; 6 d) shows the improvement in memory and cognitive function in Aβ1-42 induced AD-like disorder mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice intracerebroventricularly (icv) injected with oligomerized Aβ1-42
Dosage: 15 mg/kg
Administration: Oral gavage; 15 mg/kg; once daily; 6 days
Result: Improved the memory and cognitive function, and showed a shorter latency compared with Donepezil.
Molecular Weight

360.49

Formula

C24H28N2O

CAS No.
SMILES

O=C(NC1=CC=CC=C1C)CN(CC(C)C)CC2=CC=C3C=CC=CC3=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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BChE-IN-13
Cat. No.:
HY-151386
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