BChE-IN-13
BChE-IN-13 (Compound 17c) is an orally active, potent and selective Butyrylcholinesterase (BChE) inhibitor with IC50s of 0.22 and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 can improve memory and cognitive impairments, and be used in Alzheimer’s disease (AD) research.
For research use only. We do not sell to patients.
- CAS No.: 2700896-73-5
- Formula: C24H28N2O
- Molecular Weight:360.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.22 μM (eqBChE) 0.016 μM (hBChE)[1]
BChE-IN-13 (5-100 μM; 24 h) shows weak toxicity to SH-SY5Y, PC-12 and HT-22, and shows high mortality to BV2 cells[1].
BChE-IN-13 shows excellent blood brain barrier permeation using a parallel artificial membrane permeability assay experiment (PAMPA)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y, PC12, BV2 and HT-22 cells
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Concentration:5-100 μM
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Incubation Time:24 hours
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Result:Showed cells viability more than 60% of SH-SY5Y, PC-12 and HT-22 even at 100 μM. Showed high mortality in BV2 cells, and reached half the mortality at 20 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice intracerebroventricularly (icv) injected with oligomerized Aβ1-42
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Dosage:15 mg/kg
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Administration:Oral gavage; 15 mg/kg; once daily; 6 days
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Result:Improved the memory and cognitive function, and showed a shorter latency compared with Donepezil.
Chemical Information
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CAS No. 2700896-73-5
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Molecular Weight 360.49
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Formula C24H28N2O
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SMILES
O=C(NC1=CC=CC=C1C)CN(CC(C)C)CC2=CC=C3C=CC=CC3=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-13 Related Classifications
HY-151386 Related Classifications
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