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Cat. No.: HY-181445

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NSC 620023 TFA

NSC 620023 TFA is a highly selective butyrylcholinesterase (BChE) inhibitor with an IC₅₀ of 32 nM. NSC 620023 TFA acts via π-stacking interactions with dual benzimidazole moieties and hydrophobic interactions within the BChE binding site. NSC 620023 TFA can be used for the research of alzheimer’s disease.

For research use only. We do not sell to patients.

Formula: C₃₁H₃₀F₆N₄O₅S₂
Molecular Weight:716.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC 620023 TFA Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

hBCHE

32 nM (IC₅₀)

hAChE

>>5000 nM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

NSC 620023 (5 μM; 10-30 min) TFA potently and selectively inhibits purified human butyrylcholinesterase with an IC₅₀ of 32 nM and shows no inhibition of acetylcholinesterase at concentrations up to 5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 716.71
Formula C₃₁H₃₀F₆N₄O₅S₂
SMILES

OC1=C(C=C(C=C1CSCCC2=NC3=C(C=CC=C3)N2)C)CSCCC4=NC5=C(N4)C=CC=C5.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Williams A, et al. Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening. Bioorg Med Chem Lett. 2019;29(24):126754. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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