AChE/BChE/MAO-A-IN-2 

AChE/BChE/MAO-A-IN-2 is an AChE, BChE, and MAO-A inhibitor with IC₅₀ values of 104.28 nM, 23.04 nM, and 215.50 nM, respectively. AChE/BChE/MAO-A-IN-2 exhibits selective antiproliferative activity against cancer cells and low toxicity toward normal cells. AChE/BChE/MAO-A-IN-2 can be used for the research of alzheimer's disease, neuroblastoma^[1].

AChE/BChE/MAO-A-IN-2 (compound 5n) potently and competitively inhibits purified AChE and BChE with Ki values of 92.42 and 25.35 nM, respectively^[1].
AChE/BChE/MAO-A-IN-2 selectively inhibits the proliferation of SH-SY5Y human neuroblastoma cells with an IC₅₀ of 5.23 µM, and has a selectivity index of 8.6 relative to HUVEC normal endothelial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

556.25

C₂₂H₁₄Cl₄N₄O₃S

O=C(N/N=C/C1=CN(S(=O)(C2=CC(Cl)=CC(Cl)=C2)=O)C3=C1C=CC=C3)NC4=CC=CC(Cl)=C4Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Abbas K, et al. Design, synthesis, and multitarget evaluation of thiosemicarbazone-sulfonamide hybrids as potent cholinesterase and MAO-A inhibitors with neuroblastoma-associated cytotoxicity. Sci Rep. 2026;16(1):15736. Published 2026 May 11.