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Cat. No.: HY-127087

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Isogarcinol

(Synonyms: Cambogin)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC₅₀ values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC₅₀ of 0.33 μM against L. donovani.

For research use only. We do not sell to patients.

CAS No.: 71117-97-0
Formula: C₃₈H₅₀O₆
Molecular Weight:602.80

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (273 KB)

Isogarcinol Chemical Structure

CAS No.: 71117-97-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

AChE

1.13 ± 0.0 μM (IC₅₀)

BChE

8.30 ± 0.0 μM (IC₅₀)

Leishmania

0.33 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	19.21 μM Compound: 1	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30500683]
HEL	IC₅₀	9.24 μM Compound: 1	Antiproliferative activity against HEL cells after 72 hrs by MTT assay Antiproliferative activity against HEL cells after 72 hrs by MTT assay	[PMID: 30500683]
HeLa	IC₅₀	16.46 μM Compound: 1	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 30500683]
HepG2	IC₅₀	7.3 μM Compound: 9	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 24960143]
K562	IC₅₀	14.1 μM Compound: 1	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30500683]
L02	IC₅₀	9.3 μM Compound: 9	Cytotoxicity against human HL7702 cells by MTT assay Cytotoxicity against human HL7702 cells by MTT assay	[PMID: 24960143]
MCF7	IC₅₀	10.24 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30500683]
MCF7	IC₅₀	4.8 μM Compound: 9	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 24960143]
MDA-MB-231	IC₅₀	5.7 μM Compound: 9	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 24960143]
RAW264.7	IC₅₀	19.2 μM Compound: 9	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production	[PMID: 24960143]
U-251	IC₅₀	2.8 μM Compound: 8	Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 72 hrs by CyQuant dye-based assay Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 72 hrs by CyQuant dye-based assay	[PMID: 28729053]

Chemical Information

CAS No. 71117-97-0
Appearance Solid
Molecular Weight 602.80
Formula C₃₈H₅₀O₆
SMILES

O=C1[C@@]23C(OC(C)([C@H](C3)C/C=C(C)\C)C)=C(C([C@@]1(C(C)([C@@H](C2)C/C=C(C)\C)C)C/C=C(C)\C)=O)C(C4=CC(O)=C(C=C4)O)=O
Synonyms

Cambogin
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Cell Biochem Biophys

Isogarcinol Reduces MARS Levels and Deactivates the PI3K/AKT Pathway to Suppress the Malignant Properties of Breast Cancer Cells. [Abstract]

2025 Mar 22. PMID: 40120049

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Purity & Documentation
References

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Isogarcinol

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Isogarcinol

All Cholinesterase (ChE) Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Isogarcinol

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Isogarcinol

All Cholinesterase (ChE) Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Isogarcinol Related Classifications

HY-127087 Related Classifications