Bioactive polyprenylated benzophenone derivatives from the fruits extracts of Garcinia xanthochymus

  • Bioorg Med Chem Lett. 2017 Aug 15;27(16):3760-3765. doi: 10.1016/j.bmcl.2017.06.073.
Ui Joung Youn  1 ,  Tawanun Sripisut  2 ,  Gabriella Miklossy  3 ,  James Turkson  3 ,  Surat Laphookhieo  2 ,  Leng Chee Chang  4
Affiliations
  • 1. Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, United States; Division of Life Sciences, Korea Polar Research Institute, KIOST, Incheon 21990, Republic of Korea.
  • 2. Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.
  • 3. Natural Products and Experimental Therapeutics Program, University of Hawai'i Cancer Center, Honolulu, HI 96813, United States.
  • 4. Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, United States. Electronic address: [email protected].
PMID: 28729053 DOI: 10.1016/j.bmcl.2017.06.073
Abstract

Two new polycyclic prenylated Xanthones (1 and 2) and a new phenylpropanoid glycoside (3), along with seven known compounds (4-10) were isolated from the fruits of Garcinia xanthochymus. The structures were elucidated by 1D- and 2D-NMR, and HRMS experiments. The isolates were evaluated for their inhibitory effects against the viability of U251MG glioblastoma and MDA-MB-231 breast Cancer cells that harbor an aberrantly active signal transducer and exhibit activation of transcription 3 (STAT3), and compared to normal NIH3T3 mouse fibroblasts. Among the isolates, compounds 1, 2, 5, and 6-9 inhibited the viability of glioma Cancer cells with IC50 values in the range of 1.6-6.5μM. Furthermore, treatment of U251MG with 6 and 7 inhibited intracellular STAT3 tyrosine phosphorylation and glioma cell migration in vitro, respectively.

Keywords
Clusiaceae; Garcinia xanthochymus; Polycyclic prenylated xanthone; STAT3; Wound-healing assay.