AChE/BChE-IN-34
AChE/BChE-IN-34 is an acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with IC50s of 5.97 μM and 4.57 μM, respectively. AChE/BChE-IN-34 functions as an antioxidant, oxidative stress inhibitor, reduces MDA levels, and elevates SOD and catalase in hippocampal tissue. AChE/BChE-IN-34 acts as a cognitive function enhancer, improves learning and memory in a Scopolamine (HY-N0296)-induced animal model. AChE/BChE-IN-34 is non-toxic in neuroblastoma cells across a specified concentration range. AChE/BChE-IN-34 can be used for the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C18H14N10O3S
- Molecular Weight:450.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE 5.97 μM (IC50) |
BChE 4.57 μM (IC50) |
AChE/BChE-IN-34 (compound 4A36) (15.625-250 μg/mL; 24 h) is non-toxic to SH-SY5Y neuroblastoma cells at concentrations ranging from 15.625 to 250 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y neuroblastoma cells
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Concentration:15.625-250 μg/mL
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Incubation Time:24 h
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Result:Maintained cell viability in a dose-dependent manner, with 100% viability at 15.625 μg/mL, 97.10% viability at 31.25 μg/mL, 93.21% viability at 125 μg/mL, and 62.5% viability at 250 μg/mL. Indicated no significant cytotoxicity across the tested range.
AChE/BChE-IN-34 shows no adverse effects in acute oral toxicity evaluation up to 175 mg/kg body weight in animal models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar Albino (male/female, 200-250 g, Scopolamine-induced dementia model)[1]
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Dosage:3, 10, 30 mg/kg
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Administration:i.p.; daily; 14 days
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Result:Reduced escape latency and increased time in target quadrant (30 mg/kg, Morris Water Maze); reduced hippocampal AChE activity (30 mg/kg); decreased MDA levels and elevated SOD, Catalase activities (30 mg/kg); preserved hippocampal granular layer integrity with minimal vacuolation (30 mg/kg); showed partial improvements in cognitive function, oxidative stress markers, and histopathology at 3 and 10 mg/kg.
Chemical Information
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Molecular Weight 450.43
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Formula C18H14N10O3S
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SMILES
O=C(C1=CN=CC=C1)NNC2=NC(NC3=CC=CC=C3[N+]([O-])=O)=NC(NC4=NC=CS4)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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