AChE/BChE-IN-36
AChE/BChE-IN-36 is a dual acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with blood-brain barrier permeability. AChE/BChE-IN-36 mediates blood-brain barrier transport through specific interactions with choline transporters. AChE/BChE-IN-36 can be used for the research of Alzheimer's disease.
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- Formule: C24H30BrN3
- Masse moléculaire:440.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
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hAChE 3.14 nM (IC50) |
eqBCHE 24.5 nM (IC50) |
electric eel AChE 11.54 nM (IC50) |
AChE/BChE-IN-36 (Compound C4) potently inhibits eeAChE, hAChE and eqBChE, with IC50 values of 11.54 nM, 3.14 nM and 24.50 nM, respectively[1].
AChE/BChE-IN-36 (5 μg/mL; 0-300 min) exhibits stronger blood-brain barrier (BBB) permeability in the bEnd.3 cell Transwell model, with a Papp of 19.58 × 10-6 cm/s[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 440.42
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Formule C24H30BrN3
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SMILES
C12=NC3=C(CCCC3)C(NCCCCCC[N+]4=CC=CC=C4)=C1C=CC=C2.[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BChE-IN-36 Related Classifications
HY-182290 Related Classifications
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