BChE/MAO-B-IN-6
BChE/MAO-B-IN-6 is a dual inhibitor with inhibitory activity against both butyrylcholinesterase (BChE) and monoamine oxidase B (MAO B), with an IC50 of 557 nM against BChE and an IC50 of 142 nM against MAO B. BChE/MAO-B-IN-6 reduces IL-6 release from stimulated microglia and antagonizes 6-hydroxydopamine (HY-B1081) toxicity in neuroblastoma cells. BChE/MAO-B-IN-6 can be used in the research of neurodegenerative diseases.
For research use only. We do not sell to patients.
- Formula: C28H29NO6
- Molecular Weight:475.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-B 142 nM (IC50) |
BChE 557 nM (IC50) |
IL-6 |
BChE/MAO-B-IN-6 (Compound 9) (0.1-5 μM; 1-3 h) attenuates 6-OHDA-induced cytotoxicity in human neuroblastoma SH-SY5Y cells in a dose-dependent manner[1].
BChE/MAO-B-IN-6 (0.01-1 μM; 24 h) reduces IL-6 release in LPS/IFN-γ/H2O2-activated human microglial HMC3 cells in a dose-dependent manner, with significant inhibitory effects at concentrations of 0.1 μM and 1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y human neuroblastoma cells
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Concentration:0.1, 0.5 and 5 μM
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Incubation Time:1 h or 3 h (pre-incubation)
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Result:Significantly attenuated 6-OHDA-induced cytotoxicity at all tested concentrations; the highest protection was observed at 0.5 μM, with viability levels comparable to a combination of tacrine and safinamide at equivalent total concentration (0.1 μM total).
Chemical Information
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Molecular Weight 475.53
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Formula C28H29NO6
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SMILES
COC1=CC=C(C=C1OC)CN(CC2=CC=C(C=C2)COC3=CC=C4C(CO)=CC(OC4=C3)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE/MAO-B-IN-6 Related Classifications
HY-183798 Related Classifications
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- BChE/MAO-B-IN-6
- Cholinesterase (ChE)
- Monoamine Oxidase
- Interleukin Related
- 6-hydroxydopamine
- catalytic triad
- interleukin-6
- SH-SY5Y human neuroblastoma cells
- human butyrylcholinesterase
- HMC3 human microglia cells
- human monoamine oxidase B
- neuroblastoma cells
- neurodegenerative disorders
- microglia
- Inhibitor
- inhibitor
- inhibit