2. Neuronal Signaling Immunology/Inflammation
  3. Cholinesterase (ChE) Monoamine Oxidase Interleukin Related
  4. BChE/MAO-B-IN-6

BChE/MAO-B-IN-6 is a dual inhibitor with inhibitory activity against both butyrylcholinesterase (BChE) and monoamine oxidase B (MAO B), with an IC50 of 557 nM against BChE and an IC50 of 142 nM against MAO B. BChE/MAO-B-IN-6 reduces IL-6 release from stimulated microglia and antagonizes 6-hydroxydopamine (HY-B1081) toxicity in neuroblastoma cells. BChE/MAO-B-IN-6 can be used in the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

BChE/MAO-B-IN-6

BChE/MAO-B-IN-6 Chemical Structure

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BChE/MAO-B-IN-6 Related Antibodies

Top Publications Citing Use of Products

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AChE BChE

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MAO-A MAO-B

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

BChE/MAO-B-IN-6 is a dual inhibitor with inhibitory activity against both butyrylcholinesterase (BChE) and monoamine oxidase B (MAO B), with an IC50 of 557 nM against BChE and an IC50 of 142 nM against MAO B. BChE/MAO-B-IN-6 reduces IL-6 release from stimulated microglia and antagonizes 6-hydroxydopamine (HY-B1081) toxicity in neuroblastoma cells. BChE/MAO-B-IN-6 can be used in the research of neurodegenerative diseases[1].

IC50 & Target[1]

MAO-B

142 nM (IC50)

BChE

557 nM (IC50)

IL-6

 

In Vitro

BChE/MAO-B-IN-6 (Compound 9) (0.1-5 μM; 1-3 h) attenuates 6-OHDA-induced cytotoxicity in human neuroblastoma SH-SY5Y cells in a dose-dependent manner[1].
BChE/MAO-B-IN-6 (0.01-1 μM; 24 h) reduces IL-6 release in LPS/IFN-γ/H2O2-activated human microglial HMC3 cells in a dose-dependent manner, with significant inhibitory effects at concentrations of 0.1 μM and 1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BChE/MAO-B-IN-6 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 0.1, 0.5 and 5 μM
Incubation Time: 1 h or 3 h (pre-incubation)
Result: Significantly attenuated 6-OHDA-induced cytotoxicity at all tested concentrations; the highest protection was observed at 0.5 μM, with viability levels comparable to a combination of tacrine and safinamide at equivalent total concentration (0.1 μM total).
Molecular Weight

475.53

Formula

C28H29NO6
SMILES

COC1=CC=C(C=C1OC)CN(CC2=CC=C(C=C2)COC3=CC=C4C(CO)=CC(OC4=C3)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BChE/MAO-B-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE/MAO-B-IN-6Cholinesterase (ChE)Monoamine OxidaseInterleukin RelatedMAOIL6-hydroxydopaminecatalytic triadinterleukin-6SH-SY5Y human neuroblastoma cellshuman butyrylcholinesteraseHMC3 human microglia cellshuman monoamine oxidase Bneuroblastoma cellsneurodegenerative disordersmicrogliaInhibitorinhibitorinhibit

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