BChE/MAO-B-IN-2
BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD).
For research use only. We do not sell to patients.
- Formula: C17H22N2O2
- Molecular Weight:286.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-B 0.45 μM (IC50) |
MAO-B 0.08 μM (Ki) |
hBCHE 0.05 μM (IC50) |
hBCHE 0.01 μM (IC50) |
MAO-A 5.00 μM (IC50) |
MAO-A 1.20 μM (Ki) |
AChE 0.8 μM (Ki) |
AChE 2 μM (EC50) |
BChE/MAO-B-IN-2 (Compound 4a-S) shows DPPH radical scavenging activity (IC50 = 3.57 mM), antioxidant activity in the CUPRAC assay (IC50 = 33 μM) and superoxide anion scavenging capacity (IC50 = 24 μM)[1].
MAO-B-IN-48 (1-25 μM) does not exhibit cytotoxic effects on HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:40mg/kg of AlCl3 was administered intraperitoneally (i.p.) to male Balb/c mice for 30 days[1]
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Dosage:20 mg/kg
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Administration:i.g. for 1 week
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Result:Ameliorated the cognitive impairment induced by AlCl3 in mice.
Chemical Information
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Molecular Weight 286.37
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Formula C17H22N2O2
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SMILES
C#CCN[C@H](C1=CC(OC(N2CCCCC2)=O)=CC=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Teke Tuncel S, et al. Multitarget-directed carbamate and carbamothioate derivatives: Cholinesterase and monoamine oxidase inhibition, anti-β-amyloid (Aβ) aggregation, antioxidant and blood-brain barrier permeation properties against Alzheimer's disease. Eur J Med Chem. 2025 Nov 15;298:117986. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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