1. Neuronal Signaling
  2. Cholinesterase (ChE) Monoamine Oxidase
  3. AChE/BChE-IN-6

AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC50 values of 0.809 µM, 2.248 µM and > 100 µM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB). AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research.

For research use only. We do not sell to patients.

AChE/BChE-IN-6 Chemical Structure

AChE/BChE-IN-6 Chemical Structure

CAS No. : 2416910-94-4

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Description

AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC50 values of 0.809 µM, 2.248 µM and > 100 µM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB). AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target[1]

hMAO-B

> 100 μM (IC50)

hAChE

2.248 μM (IC50)

hBCHE

0.809 μM (IC50)

In Vitro

AChE/BChE-IN-6 (compound 22) (1-100 µM; 48 hours) can cross the blood-brain barrier and has neuroprotective to human neuronal-like SH-SY5Y and liver HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SH-SY5Y and HepG2 cells
Concentration: 1-100 µM
Incubation Time: 48 hours
Result: Had non-cytotoxic at 20 µM on SH-SY5Y cells and at 50 µM on HepG2 cells.
Molecular Weight

366.50

Formula

C23H30N2O2

CAS No.
SMILES

CC(C1=CC=C(C=C1)NC(OCC2CCN(CC2)CC3=CC=CC=C3)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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AChE/BChE-IN-6 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AChE/BChE-IN-6
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HY-146315
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