AChE/BChE-IN-6
AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC50 values of 0.809 µM, 2.248 µM and > 100 µM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB). AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research.
For research use only. We do not sell to patients.
- CAS No.: 2416910-94-4
- Formula: C23H30N2O2
- Molecular Weight:366.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hMAO-B ＞ 100 μM (IC50) |
hAChE 2.248 μM (IC50) |
hBCHE 0.809 μM (IC50) |
AChE/BChE-IN-6 (compound 22) (1-100 µM; 48 hours) can cross the blood-brain barrier and has neuroprotective to human neuronal-like SH-SY5Y and liver HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y and HepG2 cells
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Concentration:1-100 µM
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Incubation Time:48 hours
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Result:Had non-cytotoxic at 20 µM on SH-SY5Y cells and at 50 µM on HepG2 cells.
Chemical Information
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CAS No. 2416910-94-4
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Molecular Weight 366.50
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Formula C23H30N2O2
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SMILES
CC(C1=CC=C(C=C1)NC(OCC2CCN(CC2)CC3=CC=CC=C3)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BChE-IN-6 Related Classifications
HY-146315 Related Classifications
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