BChE-IN-16
BChE-IN-16 (compound 87) is a highly potent BChE inhibitor with an IC50 of 3.8 nM for hBChE. BChE-IN-16 has low cytotoxicity, potential CNS permeability, unique adaptability and can be used in Alzheimer's disease (AD) research.
For research use only. We do not sell to patients.
- Formula: C28H32FNO2
- Molecular Weight:433.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hBCHE 3.8 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
76 μM
Compound: 87
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 36996715] |
| SH-SY5Y | IC50 |
87 μM
Compound: 87
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Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 36996715] |
BChE-IN-16 has zero inhibition of hAChE when the IC50 value is greater than 10 μM[1].
BChE-IN-16 competitively inhibits hBChE with a Ki value of 4.04 nM[1].
BChE-IN-16 is cytotoxic to SH-SY5Y cells with an IC50 value of 87.0 μM[1].
BChE-IN-16 is cytotoxic to HepG2 cells with an IC50 value of 76.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 433.56
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Formula C28H32FNO2
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SMILES
COC1=CC=CC(CN(C2CCC2)CCCC3=C(C=CC=C3)F)=C1OCC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-16 Related Classifications
HY-149243 Related Classifications
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