BChE-IN-16

Cat. No.: HY-149243: Data Sheet Handling Instructions
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BChE-IN-16 (compound 87) is a highly potent BChE inhibitor with an IC₅₀ of 3.8 nM for hBChE. BChE-IN-16 has low cytotoxicity, potential CNS permeability, unique adaptability and can be used in Alzheimer's disease (AD) research.

For research use only. We do not sell to patients.

BChE-IN-16 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

hBCHE

3.8 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	76 μM Compound: 87	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 36996715]
SH-SY5Y	IC₅₀	87 μM Compound: 87	Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 36996715]

In Vitro

BChE-IN-16 has zero inhibition of hAChE when the IC₅₀ value is greater than 10 μM^[1].
BChE-IN-16 competitively inhibits hBChE with a K_i value of 4.04 nM^[1].
BChE-IN-16 is cytotoxic to SH-SY5Y cells with an IC₅₀ value of 87.0 μM^[1].
BChE-IN-16 is cytotoxic to HepG2 cells with an IC₅₀ value of 76.0 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

433.56

Formula

C₂₈H₃₂FNO₂

SMILES

COC1=CC=CC(CN(C2CCC2)CCCC3=C(C=CC=C3)F)=C1OCC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pidany F, et al. Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation. Eur J Med Chem. 2023 Apr 5;252:115301. [Content Brief]

BChE-IN-16 Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-16Cholinesterase (ChE)Alzheimer's diseaseBChEhAChE SH-SY5Y cellsHepG2 cellsInhibitorinhibitorinhibit

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