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phosphate binder

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16293
    Lurbinectedin
    Maximum Cited Publications
    7 Publications Verification

    PM01183; LY-01017

    		 DNA Alkylator/Crosslinker DNA/RNA Synthesis Cancer
    Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
    Lurbinectedin
  • HY-N1428C
    Ferric citrate
    5 Publications Verification

    Iron(III) citrate; Zerenex

    		 Reactive Oxygen Species (ROS) Antibiotic Metabolic Disease
    Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research .
    Ferric citrate
  • HY-N6800A
    Netropsin dihydrochloride
    1 Publications Verification

    		 Antibiotic DNA/RNA Synthesis Bacterial Influenza Virus Orthopoxvirus Infection Inflammation/Immunology
    Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity .
    Netropsin dihydrochloride
  • HY-153910
    AGPS-IN-1

    		Others Cancer
    AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesenchymal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells .
    AGPS-IN-1
  • HY-160116
    α-Synuclein aggregate binder 1

    		Radionuclide-Drug Conjugates (RDCs) Fluorescent Dye α-synuclein Neurological Disease
    α-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for α-synuclein aggregates and can inhibit α-synuclein aggregation. α-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit α-synuclein fibril formation by blocking the aggregation process. α-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. α-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinson's disease and Lewy body dementia .
    α-Synuclein aggregate binder 1
  • HY-B1620D
    Polyvinylpyrrolidone K25

    PVP K25; Polyvidone K25; Povidone K25

    		 Biochemical Assay Reagents Others
    Polyvinylpyrrolidone K25 is a multifunctional synthetic polymer. Polyvinylpyrrolidone K25 is a versatile excipient for both conventional formulations and novel controlled or targeted delivery systems. Polyvinylpyrrolidone K25 is a preferable binder for granules and tablets .
    Polyvinylpyrrolidone K25
  • HY-B1620C
    Polyvinylpyrrolidone K17

    PVP K17; Polyvidone K17; Povidone K17

    		 Biochemical Assay Reagents Others
    Polyvinylpyrrolidone K17 is one of the polymers in pharmaceutical preparations. Polyvinylpyrrolidone K17 is a versatile excipient for both conventional formulations and novel controlled or targeted delivery systems, serving as a binder, coating agent, suspending agent, pore-former, solubilizer, stabilizer, etc .
    Polyvinylpyrrolidone K17
  • HY-P11307
    Biotin-epoxomicin

    		Proteasome Cancer
    Biotin-epoxomicin is a Proteasome subunit binder. Biotin-epoxomicin serves as an affinity reagent for identifying proteasomal catalytic subunits, and facilitates affinity purification of active proteasomal subunits for LC-MS identification. Biotin-epoxomicin can be used to study solid tumors derived from B16 melanoma .
    Biotin-epoxomicin
  • HY-13995B
    Sevelamer carbonate
    1 Publications Verification

    		 FXR Metabolic Disease Endocrinology
    Sevelamer carbonate is an orally active polymeric phosphate binder and bile acid sequestrant. Sevelamer carbonate binds dietary phosphate in the gastrointestinal tract, reducing phosphate absorption and serum phosphorus levels, and reduces urinary phosphate excretion. Sevelamer carbonate binds polyanion bile acids, increases bile acid faecal excretion, and reduces total cholesterol and LDL cholesterol levels. Sevelamer carbonate can be used for the research of hyperphosphataemia, hyperparathyroidism, chronic renal failure, kidney disease, and type 2 diabetes .
    Sevelamer carbonate
  • HY-45072
    Croscarmellose sodium

    		Environmental Pollutants Biochemical Assay Reagents Others
    Croscarmellose sodium is a commonly used pharmaceutical additive approved by the US Food and Drug Administration (FDA). Croscarmellose sodium is used as excipients, such as the suspending agent, binder, glidant, antiadherent, and disintegrants .
    Croscarmellose sodium
  • HY-112939
    Colestilan

    MCI-196; Colestimide

    		 Biochemical Assay Reagents Metabolic Disease
    Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research .
    Colestilan
  • HY-W127558
    Cholesterol-PEG 600

    		Amyloid-β Neurological Disease
    Cholesterol-PEG 600 is a synthetic cholesterol derivative and also a Aβ (1-42) binder. Cholesterol-PEG 600 promotes the fibrillogenesis of Aβ (1-42). Cholesterol-PEG 600 is applicable to the research of Alzheimer's disease .
    Cholesterol-PEG 600
  • HY-153713
    MYC-RIBOTAC
    1 Publications Verification

    		 RIBOTAC c-Myc Apoptosis Cancer
    MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research . MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 (HY-156839), RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).
    MYC-RIBOTAC
  • HY-149934
    DCAF1 binder 1

    		Ligands for E3 Ligase Cancer
    DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD) .
    DCAF1 binder 1
  • HY-158123
    PSMA binder-1

    		PSMA Cancer
    PSMA binder-1 is a ligand for PSMA and can be used to synthesize PSMA targeting molecule, such as Ac-PSMA-trillium .
    PSMA binder-1
  • HY-146186
    JAK2 JH2 binder-1

    		JAK Cancer
    JAK2 JH2 binder-1 (compound 11) is a potent and selective JAK2 JH2 binder, with a Kd of 37.1 nM. JAK2 JH2 binder-1 has the potential for various myeloproliferative neoplasms research .
    JAK2 JH2 binder-1
  • HY-172663A
    Trabectedin derivative 1 TFA

    		DNA/RNA Synthesis Apoptosis Cancer
    Trabectedin derivative 1 TFA is a selective DNA minor groove binder. Trabectedin derivative 1 TFA inhibits DNA transcription and repair to induce tumor cell apoptosis. Trabectedin derivative 1 TFA is promising for research of solid tumors such as soft tissue sarcoma and ovarian cancer .
    Trabectedin derivative 1 TFA
  • HY-106254A
    Vapendavir diphosphate
    4 Publications Verification

    BTA798 diphosphate

    		 Enterovirus Infection Inflammation/Immunology
    Vapendavir diphosphate (BTA798 diphosphate) is a potent enteroviral capsid binder (CB). Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains .
    Vapendavir diphosphate
  • HY-B1620K
    Polyvinylpyrrolidone, average Mw~29000

    PVP, average Mw~29000; Polyvidone, average Mw~29000; Povidone, average Mw~29000

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Polyvinylpyrrolidone, average Mw~29000 is a multifunctional synthetic polymer with an average molecular weight of 29,000 Da. Polyvinylpyrrolidone, average Mw~29000 is a versatile excipient for both conventional formulations and novel controlled or targeted delivery systems, serving as a binder, coating agent, suspending agent, pore-former, solubilizer, stabilizer, etc .
    Polyvinylpyrrolidone, average Mw~29000
  • HY-111870
    PROTAC RIPK degrader-6

    		PROTACs RIP kinase Cancer
    PROTAC RIPK degrader-6 (example 1) is a Cereblon-based PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder .
    PROTAC RIPK degrader-6
  • HY-W039943
    Acetyl-cyclosporin A aldehyde

    		Molecular Glues Cancer
    Acetyl-cyclosporin A aldehyde is an acetylated Cyclosporin A (HY-B0579) derivative with a reducing aldehyde group. Cyclosporin A is a potent calmodulin inhibitor and cyclophilin binder that can target the nuclear translocation of NF-AT and cause mitochondrial damage.
    Acetyl-cyclosporin A aldehyde
  • HY-156744
    DBr-1

    		PROTACs Epigenetic Reader Domain Cancer
    DBr-1 is a potent BRD9 PROTAC degrader (KD: 13 nM). DBr-1 can overcome intrinsic resistance to VHL-degrader. Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BRD9/BRD7 bromodomains inhibitor (HY-100352) .
    DBr-1
  • HY-148433
    SpdSyn binder-1

    		Parasite Infection Inflammation/Immunology
    SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria .
    SpdSyn binder-1
  • HY-156215
    NCI-B16

    		HCV Infection
    NCI-B16 is a small molecule RNA binder and inhibits HCV viral replication .
    NCI-B16
  • HY-141536
    PSMA-ALB-56

    		Drug-Linker Conjugates for ADC Cancer
    PSMA-ALB-56 is a PSMA-targeting radioligand designed by combining the glutamate-urea PSMA-binding entity and an albumin binder .
    PSMA-ALB-56
  • HY-123885
    NSC243928 mesylate

    		TNF Receptor Cancer
    NSC243928 mesylate is a human lymphocyte antigen 6 (LY6) binder, which also acts as an inhibitor of cell growth and has anticancer activity .
    NSC243928 mesylate
  • HY-47030
    Ferric citrate hydrate

    		Environmental Pollutants Biochemical Assay Reagents Metabolic Disease
    Ferric citrate hydrate, an orally active iron supplement, is an efficacious phosphate binder. Ferric citrate hydrate can be used for iron deficiency anemia and chronic kidney disease (CKD) research .
    Ferric citrate hydrate
  • HY-106254
    Vapendavir
    4 Publications Verification

    BTA798

    		 Enterovirus Infection
    Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains .
    Vapendavir
  • HY-159758
    EcDHFR/FKBP12 F36V binder-1

    		Others Neurological Disease Cancer
    EcDHFR/FKBP12 F36V binder-1 (compound 1) is a bifunctional molecule that combines the Escherichia coli dihydrofolate reductase domain (EcDHFR) with the FKBP12 F36V domain .
    EcDHFR/FKBP12 F36V binder-1
  • HY-152242
    YEATS4-IN-1

    PFI-8

    		 Histone Methyltransferase Others
    YEATS4-IN-1 (Compound 4d) is a potent and selective YEATS4 binder that binds to the KAc recognition site of the YEATS structural domain with a Ki value of 33 nM .
    YEATS4-IN-1
  • HY-16293S
    Lurbinectedin-d3

    PM01183-d3; LY-01017-d3

    		 DNA Alkylator/Crosslinker DNA/RNA Synthesis Cancer
    Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively .
    Lurbinectedin-d3
  • HY-W133969
    Shellac

    Shellac wax-free

    		 Environmental Pollutants Others
    Shellac is a biodegradable resin composed of polyhydroxy acids, primarily aleuritic acid, shellolic acid, and jalaric acid. It originates as a resinous secretion of the insect Kerria lacca, found on several species of trees in India, Thailand, and China. shellac is used as a wood coating, a binder and encapsulate for pharmaceuticals and food supplements, and in cosmetics products.
    Shellac
  • HY-124588
    MC3343

    		DNA Methyltransferase Cancer
    MC3343, a DNMT inhibitor (EC50 of 5.7 μM) and a strong DNA binder, affects tumor proliferation by blocking OS cells in G1 or G2/M phases and induces osteoblastic differentiation through the specific re-expression of genes regulating this physiological process .
    MC3343
  • HY-158125
    PSMA binder-2

    		PSMA Cancer
    PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
    PSMA binder-2
  • HY-B0327A
    Irsogladine maleate
    3 Publications Verification

    Dicloguamine maleate; MN1695

    		 mAChR Phosphodiesterase (PDE) Inflammation/Immunology
    Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
    Irsogladine maleate
  • HY-139620
    MS83

    		PROTACs Cancer
    MS83 is a proof-of-concept PROTAC by linking the KEAP1 ligand to a BRD4/3/2 binder.
    MS83
  • HY-161626
    PSMA binder-3

    		PSMA Cancer
    PSMA binder-3 is a binder of PSMA.
    PSMA binder-3
  • HY-174226
    RNA binder 2

    		DNA/RNA Synthesis Others
    RNA binder 2 (Compound 20) is a covalent inhibitor targeting the r(CUG)exp RNA in myotonic dystrophy type 1 (DM1). RNA binder 2 binds to RNA via a Hoechst scaffold, blocking MBNL1 binding and restoring normal splicing. RNA binder 2 is promising for research of DM1 .
    RNA binder 2
  • HY-176925
    α-Synuclein aggregate binder 2

    		α-synuclein Amyloid-β Neurological Disease
    α-Synuclein aggregate binder 2 (Compound 1) is a specific alpha-synuclein binder with a Ki of 1.6 nM. α-Synuclein aggregate binder 2 has a weak binding affinity for β-amyloid aggregates with a Ki of 295 nM. α-Synuclein aggregate binder 2 can be used as a tracer in Parkinson's disease .
    α-Synuclein aggregate binder 2
  • HY-156743
    DCAF1 binder 2

    		Others Others
    DCAF1 binder 2, a ligands for E3 Ligase, involves in BRD9, kinase and selective BTK degration.
    DCAF1 binder 2
  • HY-171862
    Nef ligand-2

    		HIV Ligands for Target Protein for PROTAC Infection
    Nef ligand-2 is a binder of Nef. Nef ligand-2 is Ligands for E3 Ligase. Nef ligand-2 is the Nef Binder portion of FC-14369 (HY-171860) .
    Nef ligand-2
  • HY-144983
    E3 ligase Ligand 22

    		Ligands for E3 Ligase Cancer
    E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .
    E3 ligase Ligand 22
  • HY-156746
    DBt-10

    		PROTACs Btk Cancer
    DBt-10 is a potent BTK PROTAC degrader (DC50: 137 nM). Blue: DCAF1 binder (HY-149934); Black: linker; Pink: BTK ligand .
    DBt-10
  • HY-Y0319C1
    Calcium acetate, United States Pharmacopeia (USP) Reference Standard

    Calcium acetate (Pharmaceutical primary standard, USP)

    		 Biochemical Assay Reagents Metabolic Disease
    Calcium acetate, United States Pharmacopeia (USP) Reference Standard (Calcium acetate (Pharmaceutical primary standard, USP)), a phosphate binder that can reduce phosphorus content, United States Pharmacopeia (USP) reference standard .
    Calcium acetate, United States Pharmacopeia (USP) Reference Standard
  • HY-156745
    DDa-1

    		PROTACs Btk Cancer
    DDa-1 is a potent BTK degrader (DC50: 90 nM). Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BTK ligand (HY-107447) .
    DDa-1
  • HY-N6800
    Netropsin

    		Antibiotic DNA/RNA Synthesis Bacterial Influenza Virus Orthopoxvirus Infection Inflammation/Immunology
    Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity .
    Netropsin
  • HY-159756B
    KI-MS2-008

    		c-Myc Cancer
    KI-MS2-008 is a selective Max binder. KI-MS2-008 results in the stabilization of Max homodimers and the attenuation of Myc. KI-MS2-008 has anticancer activity against Myc-dependent cancer .
    KI-MS2-008
  • HY-160762
    IMB-H4

    		Bacterial Infection
    IMB-H4 is an antibacterial agent and BamA binder. IMB-H4 disrupts BamA-BamD interaction by binding to BamA. IMB-H4 shows growth inhibition to Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii .
    IMB-H4
  • HY-W440555
    4-Sulfocalix[4]arene

    para-Sulfonatocalix[n]arene

    		 Amyloid-β Neurological Disease
    4-Sulfocalix[4]arene (para-Sulfonatocalix[n]arene) is a amyloid-beta 42 binder with a Kd of 5.39 M. 4-Sulfocalix[4]arene can inhibit amyloid β-peptide fibrillation and reduce amyloid cytotoxicity .
    4-Sulfocalix[4]arene
  • HY-W272811
    Camphorsulfonate sodium

    		Drug Intermediate Fungal Infection
    Camphorsulfonate sodium is an organic synthesis intermediate. Camphorsulfonate sodium can be used for synthesis of derivatives with SDH inhibitory activity through scaffold hopping. Camphorsulfonate sodium is also an organocatalyst that can be used as a pore-forming additive for modulating the porosity of the graphene film. Camphorsulfonate sodium can be used for binder-free porous graphene film and fungicide research .
    Camphorsulfonate sodium

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