2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. FGFR Raf
  4. 2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose

2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose is an FGFR3 and BRAF binder, and is an isovaleryl sucrose ester that can be found in Atractylodes japonica. 2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose shows low cytotoxicity against cancer cells.

For research use only. We do not sell to patients.

2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose

2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose Chemical Structure

CAS No. : 150302-84-4

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2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose Related Antibodies

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Description

2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose is an FGFR3 and BRAF binder, and is an isovaleryl sucrose ester that can be found in Atractylodes japonica. 2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose shows low cytotoxicity against cancer cells[1].

IC50 & Target[1]

FGFR3

 

Braf

 

In Vitro

2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose (Compound 11) (0-100 μM; 48 h) does not exhibit cytotoxic activity against HCT-116 or A549 cells, with IC50 values >50 μM[1].
2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose binds weakly to FGFR3 and BRAF proteins, with binding energies of -6.87 kcal/mol (FGFR3) and -4.68 kcal/mol (BRAF)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HCT-116, A549
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Showed no inhibitory activity against HCT-116 and A549 cells, with IC50 values greater than 50 μM.
Molecular Weight

762.88

Formula

C37H62O16
CAS No.
SMILES

OC[C@@]1([C@H]([C@@H]([C@H](O1)COC(CC(C)C)=O)OC(CC(C)C)=O)OC(CC(C)C)=O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OC(CC(C)C)=O)O)OC(CC(C)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose Related Classifications

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Keywords:

2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose150302-84-4FGFRRafFibroblast growth factor receptorRaf kinasesHCT-116A549lung adenocarcinoma cellsAtractylodes japonicaFGFR3BRAFcolon cancer cellsInhibitorinhibitorinhibit

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