2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Benzquinamide hydrochloride

Benzquinamide hydrochloride  (Synonyms: P2647 hydrochloride; BZQ hydrochloride; Benzoquinamide hydrochloride)

Cat. No.: HY-U00244A Purity: 99.14%
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Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells.

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Benzquinamide hydrochloride Chemical Structure

Benzquinamide hydrochloride Chemical Structure

CAS No. : 113-69-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Benzquinamide hydrochloride:

Benzquinamide hydrochloride Related Antibodies

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Description

Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells[1][2].

IC50 & Target

Ki: 1,365, 691, and 545 nM (α2A, α2B,α2C receptor)[1]
Molecular Weight

440.96

Formula

C22H33ClN2O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O)N(CC)CC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (124.73 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2678 mL 11.3389 mL 22.6778 mL
5 mM 0.4536 mL 2.2678 mL 4.5356 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2678 mL 11.3389 mL 22.6778 mL 56.6945 mL
5 mM 0.4536 mL 2.2678 mL 4.5356 mL 11.3389 mL
10 mM 0.2268 mL 1.1339 mL 2.2678 mL 5.6694 mL
15 mM 0.1512 mL 0.7559 mL 1.5119 mL 3.7796 mL
20 mM 0.1134 mL 0.5669 mL 1.1339 mL 2.8347 mL
25 mM 0.0907 mL 0.4536 mL 0.9071 mL 2.2678 mL
30 mM 0.0756 mL 0.3780 mL 0.7559 mL 1.8898 mL
40 mM 0.0567 mL 0.2835 mL 0.5669 mL 1.4174 mL
50 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1339 mL
60 mM 0.0378 mL 0.1890 mL 0.3780 mL 0.9449 mL
80 mM 0.0283 mL 0.1417 mL 0.2835 mL 0.7087 mL
100 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5669 mL
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Benzquinamide hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzquinamide113-69-9P2647BZQBenzoquinamideP 2647P-2647Adrenergic ReceptorBeta ReceptorAntiemeticP-glycoproteinanticancerInhibitorinhibitorinhibit

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