Benzquinamide hydrochloride
Based on 1 Customer Validation
Benzquinamide (P2647; BZQ; Benzoquinamide) hydrochloride is an orally active binder of dopamine receptors and adrenergic receptors. Benzquinamide hydrochloride specifically targets dopamine D2, D3, D4 receptors and α-2A, α-2B, α-2C adrenergic receptors. Benzquinamide hydrochloride regulates blood pressure and heart rate, attenuates the pressor effect of adrenaline, and exhibits activities such as antiemesis, anxiolysis, and reduction of histamine-induced bronchoconstriction. Benzquinamide hydrochloride has good safety and does not deplete serotonin or norepinephrine in the brain. Benzquinamide hydrochloride can be used in studies related to nausea/vomiting, mental disorders, anxiety states, neurosis, and psychosis.
For research use only. We do not sell to patients.
- Purity: 99.14%
- CAS No.: 113-69-9
- Formula: C22H33ClN2O5
- Molecular Weight:440.96
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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D2 Receptor |
D3 Receptor |
D4 Receptor |
Alpha-2A adrenergic receptor |
Alpha-2B adrenergic receptor |
Alpha-2C adrenergic receptor |
Benzquinamide hydrochloride binds to human dopamine D2, D3, and D4 receptors, with the highest affinity for the D4 subtype (Ki=574 nM)[1].
Benzquinamide hydrochloride (10 μM) binds to human α2A, α2B, and α2C adrenergic receptors, with the highest affinity for the α2C subtype (Ki=545 nM), and does not produce meaningful binding to histamine H1 receptors or muscarinic M1-M5 receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Benzquinamide (5-20 mg/kg; i.p.) hydrochloride inhibits isolation-induced fighting behavior in male mice starting at 5 mg/kg (i.p.) without causing muscle relaxation or impaired coordination[2].
Benzquinamide (0.4-1.6 mg/kg; i.v.; 4.0-6.0 mg/kg; p.o.) hydrochloride blocks apomorphine-induced emesis in dogs with an intravenous ED50 of approximately 0.9 mg/kg, and fully blocks emesis at 6.0 mg/kg (p.o.)[2].
Benzquinamide (10-25 mg/kg; i.v.) hydrochloride does not deplete brain serotonin or norepinephrine concentrations in dogs at doses up to 25 mg/kg (i.v.)[2].
Benzquinamide (10 mg/kg; i.v.) hydrochloride does not exhibit neuromuscular activity in Felis catus at 10 mg/kg (i.v.)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat with anxiety-related behavior[2]
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Dosage:16.5 mg/kg (disrupting avoidance behavior); 60.5 mg/kg (disrupting escape behavior)
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Administration:i.p.
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Result:Disrupted conditioned avoidance behavior with an ED50 of 16.5 mg/kg (i.p.).
Disrupted escape behavior with an ED50 of 60.5 mg/kg (i.p.).
Achieved a specificity score (escape ED50 to avoidance ED50 ratio) of 3.7.
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Animal Model:Mature aggressio nmale mice[2]
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Dosage:5 mg/kg; 10 mg/kg; 20 mg/kg
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Administration:i.p.
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Result:Inhibited isolation-induced fighting behavior starting at 5 mg/kg (i.p.).
Caused no muscle relaxation or interference with muscular coordination at doses that reduced or prevented fighting.
Chemical Information
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CAS No. 113-69-9
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Appearance Solid
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Molecular Weight 440.96
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Formula C22H33ClN2O5
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Color Off-white to light yellow
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SMILES
O=C(C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O)N(CC)CC.[H]Cl
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Synonyms
P2647 hydrochloride; BZQ hydrochloride; Benzoquinamide hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Benzquinamide hydrochloride Related Classifications
HY-U00244A Related Classifications
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- Benzquinamide
- 113-69-9
- P2647
- BZQ
- Benzoquinamide
- P 2647
- P-2647
- Adrenergic Receptor
- Dopamine Receptor
- alpha-2B adrenergic receptors
- dopamine D2 receptors
- alpha-2A adrenergic receptors
- dopamine D3 receptors
- muscarinic M1 receptors
- alpha-2C adrenergic receptors
- muscarinic M5 receptors
- histamine H1 receptors
- guinea-pig ileum
- dopamine D4 receptors
- Inhibitor
- inhibitor
- inhibit