2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Benzquinamide hydrochloride

Benzquinamide hydrochloride  (Synonyms: P2647 hydrochloride; BZQ hydrochloride; Benzoquinamide hydrochloride)

Cat. No.: HY-U00244A
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Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells.

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Benzquinamide hydrochloride Chemical Structure

Benzquinamide hydrochloride Chemical Structure

CAS No. : 113-69-9

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Based on 1 publication(s) in Google Scholar

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Description

Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells[1][2].

IC50 & Target

Ki: 1,365, 691, and 545 nM (α2A, α2B,α2C receptor)[1]
Molecular Weight

440.96

Formula

C22H33ClN2O5
CAS No.
SMILES

O=C(C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O)N(CC)CC.[H]Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Benzquinamide hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzquinamide113-69-9P2647BZQBenzoquinamideP 2647P-2647Adrenergic ReceptorBeta ReceptorAntiemeticP-glycoproteinanticancerInhibitorinhibitorinhibit

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