2. NF-κB
  3. Keap1-Nrf2
  4. RA839

RA839 is a noncovalent small molecule binder to Keap1 with a Kd of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2.

For research use only. We do not sell to patients.

RA839 Chemical Structure

RA839 Chemical Structure

CAS No. : 1832713-02-6

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Description

RA839 is a noncovalent small molecule binder to Keap1 with a Kd of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2[1].

Molecular Weight

452.57

Formula

C25H28N2O4S
CAS No.
Appearance

Solid

SMILES

O=C([C@@H]1CN(C2=C3C=CC=CC3=C(NS(=O)(C4=C(C)C(C)=CC(C)=C4C)=O)C=C2)CC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2096 mL 11.0480 mL 22.0960 mL
5 mM 0.4419 mL 2.2096 mL 4.4192 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.90%

COA (251 KB) HNMR (493 KB) LCMS (138 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2096 mL 11.0480 mL 22.0960 mL 55.2401 mL
5 mM 0.4419 mL 2.2096 mL 4.4192 mL 11.0480 mL
10 mM 0.2210 mL 1.1048 mL 2.2096 mL 5.5240 mL
15 mM 0.1473 mL 0.7365 mL 1.4731 mL 3.6827 mL
20 mM 0.1105 mL 0.5524 mL 1.1048 mL 2.7620 mL
25 mM 0.0884 mL 0.4419 mL 0.8838 mL 2.2096 mL
30 mM 0.0737 mL 0.3683 mL 0.7365 mL 1.8413 mL
40 mM 0.0552 mL 0.2762 mL 0.5524 mL 1.3810 mL
50 mM 0.0442 mL 0.2210 mL 0.4419 mL 1.1048 mL
60 mM 0.0368 mL 0.1841 mL 0.3683 mL 0.9207 mL
80 mM 0.0276 mL 0.1381 mL 0.2762 mL 0.6905 mL
100 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5524 mL
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RA839 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RA8391832713-02-6RA 839RA-839Keap1-Nrf2Keap1Nrf2nitric-oxide synthasenitric oxidelipopolysaccharidemacrophagesInhibitorinhibitorinhibit

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