2. NF-κB
  3. Keap1-Nrf2
  4. RA839

RA839 

Cat. No.: HY-110275 Purity: 98.90%
COA Handling Instructions

RA839 is a noncovalent small molecule binder to Keap1 with a Kd of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2.

For research use only. We do not sell to patients.

RA839 Chemical Structure

RA839 Chemical Structure

CAS No. : 1832713-02-6

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Based on 1 publication(s) in Google Scholar

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Description

RA839 is a noncovalent small molecule binder to Keap1 with a Kd of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2[1].

Molecular Weight

452.57

Appearance

Solid

Formula

C25H28N2O4S
CAS No.
SMILES

O=C([C@@H]1CN(C2=C3C=CC=CC3=C(NS(=O)(C4=C(C)C(C)=CC(C)=C4C)=O)C=C2)CC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2096 mL 11.0480 mL 22.0960 mL
5 mM 0.4419 mL 2.2096 mL 4.4192 mL
10 mM 0.2210 mL 1.1048 mL 2.2096 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.90%

COA (251 KB) HNMR (493 KB) LCMS (138 KB)

Handling Instructions (2659 KB)
References
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RA839 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RA8391832713-02-6RA 839RA-839Keap1-Nrf2Keap1Nrf2nitric-oxide synthasenitric oxidelipopolysaccharidemacrophagesInhibitorinhibitorinhibit

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