1. Epigenetics
  2. Histone Methyltransferase
  3. SETDB1-TTD-IN-1 TFA

SETDB1-TTD-IN-1 TFA 

Cat. No.: HY-141539A Purity: 98.79%
Handling Instructions

SETDB1-TTD-IN-1 TFA is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD), with a Kd of 88 nM. SETDB1-TTD-IN-1 TFA can be used for the research of biological functions and disease associations of SETDB1-TTD.

For research use only. We do not sell to patients.

SETDB1-TTD-IN-1 TFA Chemical Structure

SETDB1-TTD-IN-1 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 820 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

SETDB1-TTD-IN-1 TFA is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD), with a Kd of 88 nM. SETDB1-TTD-IN-1 TFA can be used for the research of biological functions and disease associations of SETDB1-TTD[1].

IC50 & Target

Kd: 88 nM (SETDB1-TTD)[1]

In Vitro

SETDB1-TTD-IN-1 TFA shows some activity for 53BP1 and JMJD2A, with Kds of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 TFA does not show activity against 14 of the 16 tested tudor domains (Kd>100 μM)[1].
SETDB1-TTD-IN-1 (2.5-40 μM) TFA efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells[1].
SETDB1-TTD-IN-1 (2.5-40 μM; 24 h) TFA significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

583.60

Formula

C30H32F3N5O4

SMILES

CN1C[[email protected]@H](C2=CC=C(OCC3=CC=CC=C3)C=C2)C[[email protected]@H](NC4=NC5=C(C(N4CC=C)=O)NC=C5)C1.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References
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Product Name:
SETDB1-TTD-IN-1 TFA
Cat. No.:
HY-141539A
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