1. Epigenetics
  2. Histone Methyltransferase
  3. SETDB1-TTD-IN-1

SETDB1-TTD-IN-1 

Cat. No.: HY-141539
Handling Instructions

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD), with a Kd of 88 nM. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD.

For research use only. We do not sell to patients.

SETDB1-TTD-IN-1 Chemical Structure

SETDB1-TTD-IN-1 Chemical Structure

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Description

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD), with a Kd of 88 nM. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD[1].

IC50 & Target

Kd: 88 nM (SETDB1-TTD)[1]

In Vitro

SETDB1-TTD-IN-1 shows some activity for 53BP1 and JMJD2A, with Kds of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 does not show activity against 14 of the 16 tested tudor domains (Kd>100 μM)[1].
SETDB1-TTD-IN-1 (2.5-40 μM) efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells[1].
SETDB1-TTD-IN-1 (2.5-40 μM; 24 h) significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.58

Formula

C₂₈H₃₁N₅O₂

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
SETDB1-TTD-IN-1
Cat. No.:
HY-141539
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